Reactome | Ub-LRIG1[质膜]

Ub-LRIG1(质膜)

稳定的标识符

r - hsa - 8875434

类型

蛋白质(EntityWithAccessionedSequence)

物种

智人

室

等离子体膜

路径浏览器中的位置

全部展开

信号转导(人类)

- 受体酪氨酸激酶的信号传导(人类)
  - MET(智人)的信号传递
    - MET活性负调控(智人)
      - EPS15与HGS结合泛素化MET(智人)
        
        HGF:MonoUb-K,p-4Y-MET二聚体:GRB2:p-Y-CBL，(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:内多酚，(MET:Ub-LRIG1)[质膜](人类)
        
        MET:Ub-LRIG1[质膜](智人)
        
        Ub-LRIG1[质膜](智人)
        
        HGF:MonoUb-K,p-4Y-MET二聚体:GRB2:p-Y-CBL，(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:内参素:EPS15:HGS:STAM，(MET:Ub-LRIG1:EPS15:HGS:STAM)[质膜](人类)
        
        HGF:MonoUb-K,p-4Y-MET二聚体:GRB2:p-Y-CBL，(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:内多酚，(MET:Ub-LRIG1)[质膜](人类)
        
        MET:Ub-LRIG1[质膜](智人)
        
        Ub-LRIG1[质膜](智人)
      - LRIG1发生泛素化(智人)
        
        MET:Ub-LRIG1[质膜](智人)
        
        Ub-LRIG1[质膜](智人)
      - USP8去泛素化LRIG1(智人)
        
        MET:Ub-LRIG1[质膜](智人)
        
        Ub-LRIG1[质膜](智人)

外部参考信息

外部引用

UniProt: Q96JA1 LRIG1

基因名字

LRIG1, LIG1

链

信号肽:猴,链:35 - 1093

参考基因

Buogps Gene：26018 Lrig1

宇宙(基因):LRIG1 LRIG1

CTD基因:26018 LRIG1

dbSNP基因:26018 LRIG1

运用:ENSG00000144749 LRIG1

HGNC: 17360 LRIG1

KEGG基因(智人):26018 LRIG1

君主:26018 LRIG1

NCBI基因:26018 LRIG1

人类:608868 LRIG1

UCSC: Q96JA1 LRIG1

参考文本

RefSeq: NM_015541.2 LRIG1

其他标识符

0006900148

11750405 _a_at

11755110 _a_at

16955939

211596 _s_at

238339 _x_at

240140 _s_at

26018

2680602

2680603

2680604

2680605

2680606

2680607

2680610

2680612

2680613

2680614

2680617

2680620

2680621

2680622

2680625

2680631

2680634

2680637

2680641

2680642

2680644

2680645

2680661

2680669

2680683

2680684

2680685

34800 _at

63691 _at

70503 _at

8088642

A_23_P109636

GE56536

去:0003674

去:0005515

去:0005575

去:0005576

去:0005615

去:0005886

去:0007605

去:0008150

去:0009790

去:0016020

去:0016021

去:0022405

去:0031012

去:0032474

去:0048856

去:0050877

去:0060384

HMNXSV003006438

Hs.121706.1.S1_3p_s_at

Hs.207432.0.A1_3p_s_at

ILMN_1707342

ILMN_2128795

PH_hs_0022789

PH_hs_0034614

TC03001532.hg

g13537354_3p_s_at

参与

作为…的组成部分

MET:Ub-LRIG1[质膜](智人)

这个分子的其他形式

LRIG1(质膜)

推断,

Lrig1(质膜)(亩骶)

Lrig1(质膜)(鼠形)

lrig1(质膜)(非洲爪蟾蜍tropicalis)

LRIG1(质膜)(背带背带)

修改后的残留物

的名字

在未知位置的泛素化赖氨酸(Ub[胞质])

修改

乌兰巴托(胞质)

PsiMod名字

ubiquitinylated赖氨酸(MOD: 01148)

PsiMod定义

一种能有效地将肽基赖氨酸的n6 -氨基与泛素的羧基末端甘氨酸交联的蛋白质修饰

交叉引用

RefSeq

NP_056356.2

OpenTargets

ENSG00000144749

GeneCards

Q96JA1

下丘脑-垂体-肾上腺轴的

ENSG00000144749-LRIG1

运用

ENSP00000273261，ENST00000273261，ENST00000383703，ENSP00000373208，ENSG00000144749

箴

Q96JA1

灯塔,目标

Q96JA1

GlyGen

Q96JA1

PDB

4 u7m，4 u7l

扶少团团员(8)

加入	#实体	实体	信心得分	证据(完整)
UniProt: P04626 ERBB2	117	ERBB2 G309A[质膜](r - hsa - 9665349) erbb2 g309e [血浆膜](r - hsa - 9665342) ERBB2 S310F[质膜](r - hsa - 9665350) ERBB2 S310Y[质膜](r - hsa - 9665344) p-6Y-ERBB2 G309A[质膜](r - hsa - 9665381) p-6Y-ERBB2 G309E[质膜](r - hsa - 9665382) p-6Y-ERBB2 S310F[质膜](r - hsa - 9665379) p-6Y-ERBB2 S310Y[质膜](r - hsa - 9665385) p-Y-ERBB2 L755P[质膜](r - hsa - 9654268) p-Y-ERBB2 I767M[质膜](r - hsa - 9654303) p-Y-ERBB2 A775_G776insYVMA[质膜](r - hsa - 9665656) p-Y-ERBB2 T798I[质膜](r - hsa - 9654618) p-Y-ERBB2 T862A[质膜](r - hsa - 9654695) p-Y-ERBB2 T798M[质膜](r - hsa - 9654615) p-Y-ERBB2 H878Y[质膜](r - hsa - 9654833) p-Y-ERBB2 V777L[质膜](r - hsa - 9654401) p-Y-ERBB2 L755S[质膜](r - hsa - 9654194) p-Y-ERBB2 V777E[质膜](r - hsa - 9654397) p-Y-ERBB2 V777M[质膜](r - hsa - 9654398) p-Y-ERBB2 L755M[质膜](r - hsa - 9654191) p-Y-ERBB2 A771_Y772insYVMA[质膜](r - hsa - 9665652) p-Y-ERBB2 L755W[质膜](r - hsa - 9654193) p-Y-ERBB2 T733I[质膜](r - hsa - 9654610) p-Y-ERBB2 H878R[质膜](r - hsa - 9654835) p-Y-ERBB2 L869R[质膜](r - hsa - 9654730) p-Y-ERBB2 G776S[质膜](r - hsa - 9664608) p-Y-ERBB2 L869Q[质膜](r - hsa - 9654732) p-Y-ERBB2 G776L[质膜](r - hsa - 9664600) p-Y-ERBB2 G776V[质膜](r - hsa - 9664602) p-Y-ERBB2 G776C[质膜](r - hsa - 9664611) ERBB2 D769Y[质膜](r - hsa - 9646620) ERBB2 L755P[质膜](r - hsa - 9646494) ERBB2 V842I[质膜](r - hsa - 9646703) ERBB2 H878Y[质膜](r - hsa - 9646824) ERBB2 T798M[质膜](r - hsa - 9646825) ERBB2 D769H[质膜](r - hsa - 9646617) ERBB2 T862A[质膜](r - hsa - 9649434) ERBB2 A775_G776insYVMA[质膜](r - hsa - 9665621) ERBB2 L755S[质膜](r - hsa - 9646423) ERBB2 I767M[质膜](r - hsa - 9646737) ERBB2 V777L[质膜](r - hsa - 9646579) ERBB2 D769N[质膜](r - hsa - 9646636) ERBB2 T733I[质膜](r - hsa - 9646765) ERBB2 V777M[质膜](r - hsa - 9646591) ERBB2 V777E[质膜](r - hsa - 9646586) ERBB2 L755W[质膜](r - hsa - 9646516) ERBB2 L755M[质膜](r - hsa - 9646517) ERBB2 A771_Y772insYVMA[质膜](r - hsa - 9665622) ERBB2 H878R[质膜](r - hsa - 9646822) ERBB2 V842E[质膜](r - hsa - 9646710) ERBB2 T798I[质膜](r - hsa - 9646823) ERBB2 R896C[质膜](r - hsa - 9646714) ERBB2 P780_Y781insGSP[质膜](r - hsa - 9646667) ERBB2 R896H[质膜](r - hsa - 9646728) ERBB2 G778_P780insGSP[质膜](r - hsa - 9665625) ERBB2 G776S[质膜](r - hsa - 9664463) ERBB2 L869R[质膜](r - hsa - 9646827) ERBB2 L869Q[质膜](r - hsa - 9646828) ERBB2 G776C[质膜](r - hsa - 9664457) ERBB2 G776L[质膜](r - hsa - 9664454) ERBB2 G776V[质膜](r - hsa - 9664450) p-6Y-ERBB2 V777L[质膜](r - hsa - 9647214) p-6Y-ERBB2 H878Y[质膜](r - hsa - 9647215) ERBB2 L755_T759del[质膜](r - hsa - 9663599) p-6Y-ERBB2 R896C[质膜](r - hsa - 9647208) p-6Y-ERBB2 V842I[质膜](r - hsa - 9647209) p-6Y-ERBB2 I767M[质膜](r - hsa - 9647211) p-6Y-ERBB2 T862A[质膜](r - hsa - 9654692) p-6Y-ERBB2 D769H[质膜](r - hsa - 9647200) p-6Y-ERBB2 T798I[质膜](r - hsa - 9647202) p-6Y-ERBB2 L755P[质膜](r - hsa - 9647196) p-6Y-ERBB2 P780_Y781insGSP[质膜](r - hsa - 9647198) p-6Y-ERBB2 L755S[质膜](r - hsa - 9647216) p-6Y-ERBB2 A775_G776insYVMA[质膜](r - hsa - 9665650) p-6Y-ERBB2 T798M[质膜](r - hsa - 9647218) p-6Y-ERBB2 A771_Y772insYVMA[质膜](r - hsa - 9665644) p-6Y-ERBB2 D769Y[质膜](r - hsa - 9647199) p-6Y-ERBB2 V777E[质膜](r - hsa - 9647210) p-6Y-ERBB2 T733I[质膜](r - hsa - 9647195) p-6Y-ERBB2 L755M[质膜](r - hsa - 9647204) p-6Y-ERBB2 V777M[质膜](r - hsa - 9647205) p-6Y-ERBB2 V842E[质膜](r - hsa - 9647206) p-6Y-ERBB2 D769N[质膜](r - hsa - 9647207) p-6Y-ERBB2 R896H[质膜](r - hsa - 9647217) p-6Y-ERBB2 L755W[质膜](r - hsa - 9647201) p-6Y-ERBB2 G778_P780insGSP[质膜](r - hsa - 9665634) p-6Y-ERBB2 H878R[质膜](r - hsa - 9647203) p-6Y-ERBB2 E693K[质膜](r - hsa - 9665871) p-6Y-ERBB2 R677L[质膜](r - hsa - 9665864) p-6Y-ERBB2 Q709L[质膜](r - hsa - 9665865) p-6Y-ERBB2 G660D[质膜](r - hsa - 9665866) p-6Y-ERBB2 G660R[质膜](r - hsa - 9665878) p-6Y-ERBB2 V659K[质膜](r - hsa - 9665863) p-6Y-ERBB2 V659E[质膜](r - hsa - 9665874) ERBB2 R678Q[质膜](r - hsa - 9665756) ERBB2 S653C[质膜](r - hsa - 9665754) ERBB2 R677L[质膜](r - hsa - 9665759) ERBB2 G660R[质膜](r - hsa - 9665768) ERBB2 V659E[质膜](r - hsa - 9665752) ERBB2 G660D[质膜](r - hsa - 9665753) ERBB2 V659K[质膜](r - hsa - 9665769) ERBB2 Q709L[质膜](r - hsa - 9665770) ERBB2 E693K[质膜](r - hsa - 9665761) p-6Y-ERBB2 R678Q[质膜](r - hsa - 9665876) p-6Y-ERBB2 S653C[质膜](r - hsa - 9665875) p-Y1023、Y1139 Y1196、Y1221 Y1222-ERBB2(质膜)(r - hsa - 8863841) p-Y877、Y1023 Y1139、Y1196 Y1221, Y1222-ERBB2(质膜)(r - hsa - 8863836) p-Y1023, Y1139、Y1221 Y1222-ERBB2(质膜)(r - hsa - 8864084) p-Y877、Y1023 Y1139、Y1221 Y1222-ERBB2(质膜)(r - hsa - 8864090) p-Y877-ERBB2(质膜)(r - hsa - 1810438) ERBB2(质膜)(r - hsa - 372889) p-6Y-ERBB2(质膜)(r - hsa - 1963569) p-6Y, Y1112-ERBB2(质膜)(r - hsa - 8864081) p-Y-ERBB2(质膜)(r - hsa - 1678589) py, Y877-ERBB2(质膜)(r - hsa - 1810446) p-7Y, Y1112-ERBB2(质膜)(r - hsa - 8864079) p-7Y-ERBB2(质膜)(r - hsa - 1248698)	0.748	7
UniProt: P00533表皮生长因子受体	59	p-5Y-EGFRvIII(质膜)(r - hsa - 1248649) p-6Y-EGFR[网格蛋白包被内吞囊泡膜](r - hsa - 8869138) EGFRvIII(质膜)(r - hsa - 1214162) p-6Y-EGFR E746_A750del;(r - hsa - 1182985) p-6Y-EGFR;T790M[质膜](r - hsa - 1182984) p-6Y-EGFR M766_A767insASV[质膜](r - hsa - 1996343) p-6Y-EGFR D770_N771insNPH[质膜](r - hsa - 1996342) p-6Y-EGFR V738_K739insKIPVAI[质膜](r - hsa - 1996346) p-6Y-EGFR D770_N771insNPG[质膜](r - hsa - 1996335) p-6Y-EGFR E746_A750del[质膜](r - hsa - 1181214) p-6Y-EGFR L858R[质膜](r - hsa - 1173211) p-6Y-EGFR G719S[质膜](r - hsa - 1169417) p6y - egfr L747_P753delinsS[质膜](r - hsa - 1228038) p-6Y-EGFR l747_a750del督察(r - hsa - 1228044) p-6Y-EGFR L747_T751del[质膜](r - hsa - 1228041) p-6Y-EGFR L747_S752del[质膜](r - hsa - 1228040) p6y - egfr l747_t751del督察[质膜](r - hsa - 1228042) p-6Y-EGFR E746_T751delinsA[质膜](r - hsa - 1228037) p-6Y-EGFR E746_S752delinsV[质膜](r - hsa - 1228039) p-6Y-EGFR L861Q[质膜](r - hsa - 1177541) p-6Y-EGFR A289V[质膜](r - hsa - 1996334) p-6Y-EGFR T263P[质膜](r - hsa - 1996336) p-6Y-EGFR G598V[质膜](r - hsa - 1996339) p-6Y-EGFR R108K[质膜](r - hsa - 1996338) p-6Y-EGFR A289T[质膜](r - hsa - 1996341) p-6Y-EGFR G719C[质膜](r - hsa - 1177530) p-6Y-EGFR A289D[质膜](r - hsa - 1996340) p-6Y-EGFR G719A[质膜](r - hsa - 1177528) T790M[质膜](r - hsa - 1181386) T790M[质膜](r - hsa - 1181399) EGFR D770_N771insNPG[质膜](r - hsa - 1996322) EGFR V738_K739insKIPVAI[质膜](r - hsa - 1996325) EGFR M766_A767insASV[质膜](r - hsa - 1996326) EGFR D770_N771insNPH[质膜](r - hsa - 1996317) L858R[质膜](r - hsa - 1173212) EGFR G719S[质膜](r - hsa - 1169418) [质膜](r - hsa - 1181211) EGFR L747_P753delinsS[质膜](r - hsa - 1228010) EGFR A289V[质膜](r - hsa - 1996321) t751del督察[质膜](r - hsa - 1228012) t751del[质膜](r - hsa - 1228015) EGFR A289D[质膜](r - hsa - 1996327) EGFR L861Q[质膜](r - hsa - 1177542) EGFR R108K[质膜](r - hsa - 1996330) l747_a750del督察[质膜](r - hsa - 1228034) EGFR E746_T751delinsA[质膜](r - hsa - 1228031) EGFR G719A[质膜](r - hsa - 1177532) EGFR A289T[质膜](r - hsa - 1996306) EGFR E746_S752delinsV[质膜](r - hsa - 1228025) EGFR G719C[质膜](r - hsa - 1177531) EGFR T263P[质膜](r - hsa - 1996315) G598V[质膜](r - hsa - 1996314) [质膜](r - hsa - 1228016) 表皮生长因子受体(核内体膜)(r - hsa - 9611160) p-4Y-EGFR(质膜)(r - hsa - 180287) p-Y992、Y1045 Y1068、Y1086 Y1173-EGFR(质膜)(r - hsa - 8864019) p-Y1086, Y1101-EGFR(质膜)(r - hsa - 179868) 表皮生长因子受体(质膜)(r - hsa - 179837) p-6Y-EGFR(质膜)(r - hsa - 179803)	0.743	6
UniProt: Q15303 ERBB4			0.589	3.
UniProt: P22681 CBL	39	CBL R420Q(胞质)(r - hsa - 9706186) CBL R420G(胞质)(r - hsa - 9706203) CBL Y371H(胞质)(r - hsa - 9706680) CBL H398Y(胞质)(r - hsa - 9706639) CBL P417A(胞质)(r - hsa - 9706636) CBL S376F(胞质)(r - hsa - 9706643) CBL del366 - 409(胞质)(r - hsa - 9706179) CBL del366 - 477(胞质)(r - hsa - 9706176) CBL R499L(胞质)(r - hsa - 9706678) CBL L380P(胞质)(r - hsa - 9706630) CBL L287R(胞质)(r - hsa - 9706693) CBL L380R(胞质)(r - hsa - 9706635) CBL G375P(胞质)(r - hsa - 9706219) CBL P417L(胞质)(r - hsa - 9706634) CBL H398Q(胞质)(r - hsa - 9706633) CBL P417R(胞质)(r - hsa - 9706632) CBL R499 (胞质)(r - hsa - 9706670) CBL H398R(胞质)(r - hsa - 9706638) CBL H398P(胞质)(r - hsa - 9706637) CBL G375fs 16(胞质)(r - hsa - 9706211) CBL R420 *(胞质)(r - hsa - 9706208) CBL H398D(胞质)(r - hsa - 9706631) CBL Y371C(胞质)(r - hsa - 9706694) CBL G375S(胞质)(r - hsa - 9706214) CBL Y371D(胞质)(r - hsa - 9706687) CBL Y371S(胞质)(r - hsa - 9706674) CBL P417S(胞质)(r - hsa - 9706642) CBL H398N(胞质)(r - hsa - 9706641) CBL R420P(胞质)(r - hsa - 9706193) CBL Y371N(胞质)(r - hsa - 9706679) CBL R499Q(胞质)(r - hsa - 9706677) CBL R420L(胞质)(r - hsa - 9706197) CBL P417H(胞质)(r - hsa - 9706644) p-Y-CBL(胞质)(r - hsa - 8875457) p-Y371-CBL(胞质)(r - hsa - 182940) p-Y371-CBL(质膜)(r - hsa - 182923) PolyUb、p-Y700 Y731, Y774-CBL(胞质)(r - hsa - 8848826) p-Y700、Y731 Y774-CBL(胞质)(r - hsa - 912656) CBL(胞质)(r - hsa - 112199)	0.524	2
UniProt: Q6UXM1 LRIG3			0.524	7
UniProt: Q9UPQ0-1 LIMCH1			0.463	2
UniProt: Q8WWI1-3 LMO7			0.463	2
UniProt: P00533-4表皮生长因子受体			0.463	2

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