NLRP3(低温荧林)炎性炎症目前是最合适的。它由NLRP3,ASC(Pycard)和Procaspase-1组成;CARD8(红衣主教)也被认为是一个组成部分。它由许多病原体和细菌毒素以及多样化的纸浆,危险相关的分子图(潮湿)和透明质酸和尿酸等细菌毒素,以及诸如二氧化硅和石棉等外源刺激物(参见表S1 Schroder&Tschopp,2010)。
NLRP3中的突变导致组成型激活与人类疾病混合井综合征,家族性感冒自动炎症综合征和Nomid(Ting等人2006)相关联,其特征在于皮疹和与广义炎症相关的其他症状。这些症状的原因是不受控制的IL-1 Beta生产。Multiple studies have shown that activation of the NLRP3 inflammasome by particulate activators (e.g. Hornung et al. 2008) requires phagocytosis, but this is not required for the response to ATP, which is mediated by the P2X7 receptor (Kahlenberg & Dubyak, 2004) and appears to involve the pannexin membrane channel (Pellegrin & Suprenenant 2006). Direct binding of activators to NLRP3 has not been demonstrated and the exact process of activation is unclear, though it is speculated to involve changes in conformation that free the NACHT domain for oligomerization (Inohara & Nunez 2001, 2003).