Reactome | k48polyb - nik [cytosol]

K48polyUb-NIK(胞质)

稳定的标识符

r - hsa - 5668525

类型

蛋白质(EntityWithAccessionedSequence)

物种

智人

室

胞质

同义词

MAP3K14，丝裂原活化蛋白激酶激酶激酶14,NF-kB诱导激酶

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外部参考信息

外部引用

UniProt: Q99558 MAP3K14

基因名字

MAP3K14,尼克

链

链:1 - 947

参考基因

BioGPS基因:9020 MAP3K14

宇宙(基因):MAP3K14 MAP3K14

CTD基因:9020 MAP3K14

dbSNP基因:9020 MAP3K14

运用:ENSG00000006062 MAP3K14

HGNC: 6853 MAP3K14

KEGG基因(智人):9020 MAP3K14

君主:9020 MAP3K14

NCBI基因:9020 MAP3K14

人类:604655 MAP3K14

UCSC: Q99558 MAP3K14

参考文本

其他标识符

0004010152

11724902 _a_at

11724903 _a_at

16845876

205192 _at

3759702

3759703

3759705

3759706

3759707

3759708

3759709

3759710

3759712

3759713

3759717

3759719

3759720

3759721

3759722

3759730

3759732

3759733

3759734

3759735

3759736

3759737

3759740

3759741

3759752

8016194

9020

974年_at

A_23_P207319

GE60277

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去:0006955

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去:0051607

去:0071260

去:0106310

去:0106311

HMNXSV003030142

ILMN_1724070

PH_hs_0025776

TC17001598.hg

Y10256_at

g4505396_3p_at

参与

作为输入

蛋白酶体降解k48polyb - nik(人类)

作为输出

cIAP1,2在cIAP1,2:TRAF2::TRAF3:NIK中泛素化NIK(人类)

这个分子的其他形式

活跃的尼克(胞质)

MAP3K14(胞质)

p-MAP3K14(胞质)

p-T559-MAP3K14(胞质)

推断,

map3k14a(胞质)(鲐鱼类)

win1(胞质)(粟酒裂殖酵母)

MAP3K14(胞质)(牛)

MAP3K14(胞质)(犬属后裔)

MAP3K14(胞质)(背带背带)

MAP3K14(胞质)(野猪)

map3k14(胞质)(非洲爪蟾蜍tropicalis)

SSK22(胞质)(酿酒酵母)

Map3k14(胞质)(亩骶)

Map3k14(胞质)(鼠形)

修改后的残留物

的名字

泛素化赖氨酸(k48polyb [cytosol])，位置未知

修改

K48polyUb(胞质)

PsiMod名字

ubiquitinylated赖氨酸(MOD: 01148)

PsiMod定义

一种能有效地将肽基赖氨酸的n6 -氨基与泛素的羧基末端甘氨酸交联的蛋白质修饰

交叉引用

RefSeq

XP_011523743.1，NP_003945.2

药理学指南-目标

2074

OpenTargets

ENSG00000006062

锌-物质

M3K14_HUMAN

锌的目标

Q99558

锌-生物

M3K14_HUMAN

箴

Q99558

PDB

4价值，6 z1t，6 z1q，4 g3d，6 wpp，4 dn5，4踊跃参与

下丘脑-垂体-肾上腺轴的

ENSG00000006062-MAP3K14

GeneCards

Q99558

运用

ENSP00000482657，ENSP00000478552，ENST00000344686，ENSG00000006062，ENST00000376926

灯塔,目标

Q99558

锌-预测-可购买

M3K14_HUMAN

Orphanet

23729

HMDB蛋白质

HMDBP01177

扶少团团员(42)

加入	#实体	实体	信心得分	证据(完整)
UniProt: O15111柷	3.	柷(胞质)(r - hsa - 168104) p-S176, S180-CHUK(胞质)(r - hsa - 177667) p-T23-CHUK(胞质)(r - hsa - 198615)	0.936	12
UniProt: Q13114 TRAF3	5	K48polyUb-TRAF3(胞质)(r - hsa - 5668444) TRAF3 R118W(胞质)(r - hsa - 5602321) K48polyUb-TRAF3(胞质)(r - hsa - 936556) TRAF3(胞质)(r - hsa - 914241) K63polyUb-TRAF3(胞质)(r - hsa - 936402)	0.85	8
UniProt: O14920 IKBKB	3.	IKBKB(胞质)(r - hsa - 168114) IKBKB Q432Pfs * 62(胞质)(r - hsa - 9628518) p-S177, S181-IKBKB(胞质)(r - hsa - 202506)	0.829	5
UniProt: Q16543 CDC37	1	CDC37(胞质)(r - hsa - 1221609)	0.758	5
UniProt: Q12933 TRAF2	5	K63polyUb-TRAF2(核浆)(r - hsa - 8862194) TRAF2(核浆)(r - hsa - 8862199) K63polyUb-TRAF2(胞质)(r - hsa - 8862193) PolyUb-TRAF2(胞质)(r - hsa - 6782848) TRAF2(胞质)(r - hsa - 66370)	0.749	9
UniProt: P08238 HSP90AB1	6	HSP90AB1(细胞外地区)(r - hsa - 6806463) HSP90AB1[分泌颗粒腔](r - hsa - 6801477) HSP90AB1[富ficolin-1颗粒腔](r - hsa - 6801491) HSP90AB1(胞质)(r - hsa - 419617) HSP90AB1(核浆)(r - hsa - 5082399) HSP90AB1(溶酶体腔)(r - hsa - 9622846)	0.688	5
UniProt: P27708 CAD	1	CAD(胞质)(r - hsa - 73452)	0.669	3.
UniProt: P07900 HSP90AA1	8	HSP90AA1[分泌颗粒腔](r - hsa - 6801515) HSP90AA1[内吞性囊泡腔](r - hsa - 3221912) HSP90AA1(细胞外地区)(r - hsa - 3221946) HSP90AA1[富ficolin-1颗粒腔](r - hsa - 6801470) HSP90AA1(质膜)(r - hsa - 534996) HSP90AA1(核浆)(r - hsa - 5082401) HSP90AA1(胞质)(r - hsa - 192864) HSP90AA1(溶酶体腔)(r - hsa - 9622850)	0.669	4
UniProt: P05186 ALPL	2	GPI-ALPL(质膜)(r - hsa - 8940714) cleaved GPI-ALPL[细胞外区](r - hsa - 8943383)	0.611	4
UniProt: P61353 RPL27	1	RPL27(胞质)(r - hsa - 72440)	0.564	3.
UniProt: P36578 RPL4	1	RPL4(胞质)(r - hsa - 72474)	0.564	3.
UniProt: P62424 RPL7A	1	RPL7A(胞质)(r - hsa - 72488)	0.564	3.
UniProt: P62269 RPS18	2	RPS18(胞质)(r - hsa - 72341) RPS18(核浆)(r - hsa - 6798701)	0.564	2
UniProt: P50914 RPL14	1	RPL14(胞质)(r - hsa - 72414)	0.564	3.
UniProt: P62280 RPS11	2	RPS11(胞质)(r - hsa - 72327) RPS11(核浆)(r - hsa - 6791212)	0.564	3.
UniProt: P26373 RPL13	1	RPL13(胞质)(r - hsa - 72410)	0.564	3.
UniProt: P27635 RPL10	1	RPL10(胞质)(r - hsa - 72402)	0.564	3.
UniProt: Q07020 RPL18	1	RPL18(胞质)(r - hsa - 72420)	0.564	3.
UniProt: P17066 HSPA6	5	HSPA6(核浆)(r - hsa - 5252088) HSPA6(胞质)(r - hsa - 3371521) HSPA6[分泌颗粒腔](r - hsa - 6801472) HSPA6(细胞外地区)(r - hsa - 6806500) HSPA6[富ficolin-1颗粒腔](r - hsa - 6801512)	0.564	3.
UniProt: P62906 RPL10A	1	RPL10A(胞质)(r - hsa - 72404)	0.564	3.
UniProt: P62829 RPL23	1	RPL23(胞质)(r - hsa - 72430)	0.564	3.
UniProt: P62910 RPL32	1	RPL32(胞质)(r - hsa - 72456)	0.564	3.
UniProt: P83731 RPL24	1	RPL24(胞质)(r - hsa - 72434)	0.564	3.
UniProt: Q02878 RPL6	1	RPL6(胞质)(r - hsa - 72484)	0.564	3.
UniProt: Q96L21 RPL10L	1	RPL10L(胞质)(r - hsa - 8868799)	0.564	3.
UniProt: P32969 RPL9	1	RPL9(胞质)(r - hsa - 72492)	0.564	3.
UniProt: O95816 BAG2	1	BAG2(胞质)(r - hsa - 5255445)	0.564	3.
UniProt: P18124 RPL7	1	RPL7(胞质)(r - hsa - 72486)	0.564	3.
UniProt: P39023 RPL3	1	RPL3(胞质)(r - hsa - 72448)	0.564	3.
UniProt: Q3ZCQ8 TIMM50	1	TIMM50[线粒体内膜](r - hsa - 1252070)	0.564	2
UniProt: P62917 RPL8	1	RPL8(胞质)(r - hsa - 72490)	0.564	3.
UniProt: P11142 HSPA8	10	HSPA8[分泌颗粒腔](r - hsa - 6801530) Me3K561-HSPA8(核浆)(r - hsa - 8932217) HSPA8(细胞外地区)(r - hsa - 6805936) HSPA8[富ficolin-1颗粒腔](r - hsa - 6801494) HSPA8(核浆)(r - hsa - 5082380) HSPA8(质膜)(r - hsa - 936508) HSPA8[网格蛋白塑造的-氨基丁酸转运囊泡膜](r - hsa - 888599) HSPA8[晚期核内体管腔](r - hsa - 9631104) HSPA8(溶酶体腔)(r - hsa - 9625182) HSPA8(胞质)(r - hsa - 264476)	0.564	3.
UniProt: P52272 HNRNPM	1	HNRNPM(核浆)(r - hsa - 71949)	0.564	3.
UniProt: Q9Y6K9 IKBKG	12	IKBKG(核浆)(r - hsa - 4755413) SUMO1-K277, K309-IKBKG(核浆)(r - hsa - 4755449) IKBKG D406V(胞质)(r - hsa - 5262943) IKBKG L153R(胞质)(r - hsa - 5262879) IKBKG E391 (胞质)(r - hsa - 5262924) IKBKG C417R(胞质)(r - hsa - 5262858) IKBKG R173G(胞质)(r - hsa - 5262966) IKBKG R175P(胞质)(r - hsa - 5262916) IKBKG wro 420 * 447(胞质)(r - hsa - 5262978) 乌兰巴托- 285 ikbkg(胞质)(r - hsa - 741397) K63polyUb-NEMO(胞质)(r - hsa - 202530) IKBKG(胞质)(r - hsa - 168108)	0.564	3.
UniProt: P62277 RPS13	2	RPS13(胞质)(r - hsa - 72331) RPS13(核浆)(r - hsa - 6791198)	0.564	3.
UniProt: P62847 RPS24	2	RPS24(胞质)(r - hsa - 72355) RPS24(核浆)(r - hsa - 6791186)	0.564	2
UniProt: P01112极品	23	HRAS Q61L[质膜](r - hsa - 6802452) HRAS Q61R[质膜](r - hsa - 6802458) HRAS Q61K[质膜](r - hsa - 6802442) HRAS G13R[质膜](r - hsa - 6802368) HRAS G12V[质膜](r - hsa - 6802350) HRAS G12S[质膜](r - hsa - 6802343) HRAS T58I[质膜](r - hsa - 9656014) HRAS G13C[质膜](r - hsa - 9656008) HRAS K117R[质膜](r - hsa - 9656010) HRAS G13V[质膜](r - hsa - 9656579) HRAS G13D[质膜](r - hsa - 9656572) HRAS G13S[质膜](r - hsa - 9656574) HRAS K117N[质膜](r - hsa - 9656603) HRAS G12D[质膜](r - hsa - 9656564) HRAS G12C[质膜](r - hsa - 9656561) 极品(质膜)(r - hsa - 62717) proHRAS(胞质)(r - hsa - 9647765) S-Farn-proHRAS[内质网膜](r - hsa - 9647918) S-Farn-HRAS[内质网膜](r - hsa - 9647788) 内质网膜(r - hsa - 9647796) S-Farn-Me PalmS高尔基膜(r - hsa - 9647896) 质膜(r - hsa - 9665052) HRAS[质膜](r - hsa - 9647912)	0.556	3.
UniProt: Q60680-2柷			0.544	3.
UniProt: Q9Y4K3 TRAF6	8	PolyUb-TRAF6(胞质)(r - hsa - 6782845) K48polyUb-TRAF6(胞质)(r - hsa - 6783233) TRAF6(胞质)(r - hsa - 166366) K63polyUb-TRAF6(胞质)(r - hsa - 2685681) K63polyUb-TRAF6(质膜)(r - hsa - 936980) K63polyUb-TRAF6(核内体膜)(r - hsa - 450227) TRAF6(质膜)(r - hsa - 936955) TRAF6(核内体膜)(r - hsa - 450272)	0.536	2
UniProt: Q9Y5L4 TIMM13	2	4 × hc - timm13[线粒体膜间空间](r - hsa - 1252199) TIMM13[线粒体膜间隙](r - hsa - 1307781)	0.527	3.
UniProt: Q00653 NFKB2	8	NFKB2(1 - 900)(胞质)(r - hsa - 2677931) SUMO1-K90、K298 K689 K863-NFKB2(1 - 900)(胞质)(r - hsa - 4755500) p52(核浆)(r - hsa - 5607655) p52(胞质)(r - hsa - 5607634) K48-polyUb-p-7S-p100(胞质)(r - hsa - 5607636) p-7S-p100(胞质)(r - hsa - 5607629) NFKB2(1 - 454)(核浆)(r - hsa - 177674) NFKB2(1 - 454)(胞质)(r - hsa - 168144)	0.527	3.
UniProt: Q14974 KPNB1	5	KPNB1(核浆)(r - hsa - 180714) KPNB1[富ficolin-1颗粒腔](r - hsa - 6800978) KPNB1(胞质)(r - hsa - 180733) KPNB1[特定颗粒腔](r - hsa - 6799646) KPNB1(细胞外地区)(r - hsa - 6806306)	0.499	2

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