BioPAX途径由Reactome数据库中的“ARL2:GTP结合PDE6D on KRAS4B”转化而来。
从左到右
ARL2:GTP结合PDE6D在KRAS4B上
ARL2:GTP与PDE6D上的变构位点结合,促进PDE6D的构象变化,释放KRAS4B上的戊酮(ISMail等,2011; Schmick等,2014;在Schmick等,2015中审查)。虽然细节仍然是完全建立的,但是,在从PDE6D中释放后,kras4b可以通过与克切脊髓植物的带负电荷的膜相互作用来再循环到质膜膜(Chen等,2010; Schmick等,2014;在施米克等,2015年审查)。
作者:罗斯菲尔斯,凯伦,2019-10-25
评论:Gavathiotis, Evripidis, 2020年05月04日
编辑:Rothfels, Karen, 2020-05-26
ARL2:GTP.
反应DB_ID:5250197
胞质
基因本体论
去:0005829
GTP.
鸟嘌呤核苷5 '三磷酸
Reactome DB_ID: 29438
三磷酸鸟苷(ChEBI: 15996)
GTP.
鸟嘌呤核苷5 '三磷酸
Chebi.
CHEBI: 15996
Reactome数据库ID Release 77
29438
数据库标识符。使用此URL在反弹中连接到此实例的网页:http://www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=29438
Reactome
r - - 29438
3.
Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页:http://www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-all-29438.3
Reactome
//www.joaskin.com
化合物
C00044
附加信息
心肌梗死
MI:0361
1
ARL2.
二磷酸核糖基化因子样蛋白2
ARL2_HUMAN
Reactome DB_ID: 5216230
UNIPROT:P36404 ARL2
ARL2.
功能小GTP结合蛋白,其在无活性GDP结合和活性GTP结合形式之间循环,并且通过鸟嘌呤核苷酸交换因子(GEF)和GTP酶活化蛋白(间隙)调节循环速率。GTP结合蛋白不能作为霍乱毒素催化亚基的变构激活剂。调节新的微管和中心系列的形成。防止TBCD诱导的微管破坏。与TBCD相关联,在拆卸顶部结络合物中。拮抗TBCD对上皮细胞脱离,紧密,粘附的交叉点拆卸的影响。与ARL2一起起在STAT3的核易位,保留和转录活动中发挥作用。调节分泌途径的组分参与Ca(2 +) - 依乙酰胆碱的依赖性释放。通过细胞周期进行正常进展所需的。在ARL2,ARL2BP和SLC25A6中的复合物中发现。在具有至少ARL2,PPP2CB,PPP2R1A,PPP2R2A,PPP2R5E和TBCD的复合物中发现。 Found in a complex with ARL2, ARL2BP and SLC25A4. The GTP-bound form interacts with PDE6D. Interacts with ELMOD2. The GTP-bound form interacts with ARL2BP. Interacts, preferentially in its GDP-bound state, with TBCD. Interacts with UNC119.PTM Not N-myristoylated.SIMILARITY Belongs to the small GTPase superfamily. Arf family.
HOMO SAPIENS.
NCBI分类学
9606
uniprot.
P36404
2
平等的
184
平等的
Reactome数据库ID Release 77
5216230
数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=5216230
Reactome
R-HSA-5216230
1
Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5216230.1
1
Reactome数据库ID Release 77
5250197
数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=5250197
Reactome
r - hsa - 5250197
1
Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5250197.1
S-FARN-ME KRAS4B:CALM1:4xCa2 +:PDE6D
Reactome DB_ID: 9654515
PDE6D
视网膜视紫质棒敏感的cGMP 3' ,5'-环磷酸亚基增量
PDE6D_HUMAN
Reactome DB_ID:2565921
UniProt的:O43924 PDE6D
PDE6D
问题一
功能促进从细胞膜中脱苯基化靶蛋白的释放(Pubmed:9712853)。通过调节其亚细胞位置(Pubmed:22002721,PubMed:23698361)来调节普苯胺化或棕榈酰胺的RAS系列成员的活性。法牛酸化靶蛋白的正常睫状靶位所需的靶向,例如INPP5E(PUBMED:24166846)。通过用作GTP特异性解离抑制剂(GDI)来调节靶蛋白的亚细胞位置(通过相似性)。通过几个数量级增加了ARL3对GTP的亲和力。通过降低核苷酸解离速率(通过相似性)来稳定ARL3-GTP .SubUnit与PDE6的戊酰基催化亚基相互作用,由两个催化链(PDE6A和PDE6B)和两个抑制链(γ)组成的低聚物;对酶活性没有影响,但促进从细胞膜(相似性)中脱苯化酶的释放。与prenylated GRK1和GRK7(通过相似性)相互作用。与戊酰化的RAS系列成员相互作用,包括RAP2A和RAP2C(按照相似性)。与戊酰化的RhEB和NRA相互作用(PubMed:22002721)。 Interacts with prenylated HRAS and KRAS. Interacts with RAB13 (prenylated form); dissociates RAB13 from membranes (PubMed:9712853). Interacts with prenylated INPP5E (PubMed:24166846). Interacts with RPGR (PubMed:9990021, PubMed:24166846, PubMed:23559067). Interacts with ARL2 (PubMed:24166846, PubMed:22002721). Interacts with ARL3; the interaction occurs specifically with the GTP-bound form of ARL3 (PubMed:24166846). Interaction with ARL2 and ARL3 promotes release of farnesylated cargo proteins (PubMed:22002721).TISSUE SPECIFICITY Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.SIMILARITY Belongs to the PDE6D/unc-119 family.
uniprot.
O43924
1
平等的
150
平等的
Reactome数据库ID Release 77
2565921
数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=2565921
Reactome
R-HSA-2565921
1
Reactome稳定的标识符。使用此URL将此实例的Web页面连接到Reactome:http://www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-2565921.1
1
S-Farn-Me KRAS4B: CALM1:4xCa2 +
Reactome DB_ID: 9654512
RASK_HUMAN
S-FARN-ME KRAS4B
GTPase喀斯特
Reactome DB_ID: 9654510
UniProt: P01116-2喀斯特
喀斯特
Kras2.
RASK2
FUNCTION Ras蛋白结合GDP / GTP和具有内在的GTP酶活性(搜索PubMed:20949621)。在细胞增殖调控中起重要作用(PUBMED:23698361,考研:22711838)。起着通过诱导在大肠癌的肿瘤抑制基因(肿瘤抑制基因)的转录沉默促进致癌事件中的作用(CRC)细胞在ZNF304依赖性(PUBMED:24623306).ACTIVITY规候补绑定到GDP和活性无活性形式之间形成结合到GTP。通过鸟嘌呤核苷酸交换因子(GEF)激活,并通过一个GTP酶激活蛋白(GAP)失活。与SOS1相互作用促进与PHLPP GTP.SUBUNIT交互结合的GDP的交换。相互作用(活性GTP结合形式优先)与RGS14(通过相似性)。相互作用(法尼基时)与PDE6D;这促进了从细胞膜解离(PUBMED:23698361)。与SOS1交互(PUBMED:22431598)。 Interacts (when farnesylated) with GPR31 (PubMed:28619714).PTM Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).PTM Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.PTM (Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL.DISEASE Defects in KRAS are a cause of pylocytic astrocytoma (PA). Pylocytic astrocytomas are neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors.DISEASE KRAS mutations are involved in cancer development.SIMILARITY Belongs to the small GTPase superfamily. Ras family.
UniProt同种型
P01116-2
186
平等的
S-farnesyl-L-cysteine甲基酯
国防部
mod:01116
1
平等的
186
平等的
Reactome数据库ID Release 77
9654510
数据库标识符。使用此URL将此实例的网页连接到反应组:http://www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=9654510
Reactome
R-HSA-9654510
1
Reactome稳定的标识符。使用此URL连接到该实例的网页中Reactome://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9654510.1
1
CALM1:4xCa2 +
活跃的钙调蛋白
Reactome DB_ID: 74294
CA2 +
钙
钙(2+)
Reactome DB_ID: 74016
钙(2 +)(ChEBI: 29108)
钙(2+)
Chebi.
CHEBI: 29108
Reactome数据库ID Release 77
74016.
数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=74016
Reactome
r - - 74016
3.
Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74016.3
化合物
C00076
4.
CALM1
钙调蛋白
CALM_HUMAN
Reactome DB_ID: 9016707
UniProt: P0DP23 CALM1
CALM1
冷静的
凸轮
CAM1
功能钙调蛋白通过钙结合介导大量酶,离子通道,水素和其他蛋白质的控制。由钙调蛋白 - 钙络合物刺激的酶中是许多蛋白激酶和磷酸酶。与CCP110和Centrin一起参与遗传途径,通过细胞因子调节Centosome循环和进展(PubMed:16760425)。是电压依赖性L型钙通道的调节器(PubMed:31454269)。介导CACNA1C的钙依赖性灭活(PUBMED:26969752)。阳性调节KCNN2的钙激活钾通道活性(PubMed:27165696)。用KCNQ1形成钾通道络合物,并通过钙结合调节通道的电生理活性(PubMed:25441029)。作为传感器,用VMP1:ATP2A2(PUBMED:28890335)的其他细胞器调节endompatumic网状触点的传感器。•军团菌Pneumophila Sidj谷氨酰胺酶活性所需的其他细胞器。津属植物蛋白活性酶活性与MyO1c,Myo5a和Rrad相互作用。与MyO10(相似性)互动。与CEP97,CCP110,TTN / TITIN和SRIN(PUBMED:9804419,PUBMED:12871148,PUBMED:15746192,PUBMED:16760425,PUBMED:17719545)与CCP177,CCP110 Interacts with USP6; the interaction is calcium dependent (PubMed:16127172). Interacts with CDK5RAP2 (PubMed:20466722). Interacts with SCN5A (PubMed:21167176). Interacts with RYR1 (PubMed:18650434). Interacts with FCHO1 (PubMed:22484487). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (PubMed:23893133). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with IQCF1 (By similarity). Interacts with SYT7 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:27516456, PubMed:18650434, PubMed:26164367). Interacts with PCP4; regulates calmodulin calcium-binding (PubMed:27876793). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (PubMed:27564677). Interacts with alpha-synuclein/SNCA (PubMed:23607618). Interacts with SLC9A1 in a calcium-dependent manner (PubMed:30287853). In the absence of Ca(+2), interacts with GIMAP4 (via IQ domain) (By similarity). Interacts with SCN8A; the interaction modulates the inactivation rate of SCN8A (By similarity). Interaction with KIF1A; the interaction is increased in presence of calcium and increases neuronal dense core vesicles motility (PubMed:30021165). Interacts with KCNN3 (PubMed:31155282). Interacts with KCNQ1 (via C-terminus); forms a heterooctameric structure (with 4:4 KCNQ1:CALM stoichiometry) in a calcium-independent manner (PubMed:18165683,PubMed:25441029). Interacts with PIK3C3; the interaction modulates PIK3C3 kinase activity (PubMed:28890335).SUBUNIT (Microbial infection) Interacts with Rubella virus protease/methyltransferase p150.SUBUNIT (Microbial infection) Interacts with Legionella pneumophila glutamylase SidJ.DOMAIN The N-terminal and C-terminal lobes of CALM bind to the C-terminus of KCNQ1 in a clamp-like conformation. Binding of CALM C-terminus to KCNQ1 is calcium-independent but is essential for assembly of the structure. Binding of CALM N-terminus to KCNQ1 is calcium-dependent and regulates electrophysiological activity of the channel.PTM Ubiquitination results in a strongly decreased activity.PTM Phosphorylation results in a decreased activity.MISCELLANEOUS This protein has four functional calcium-binding sites.SIMILARITY Belongs to the calmodulin family.
uniprot.
P0DP23
2
平等的
149
平等的
Reactome数据库ID Release 77
9016707
数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9016707
Reactome
R-HSA-9016707
1
Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9016707.1
1
Reactome数据库ID Release 77
74294
数据库标识符。使用此URL在反弹中连接到此实例的网页:http://www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=74294
Reactome
r - hsa - 74294
3.
Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-74294.3
1
Reactome数据库ID Release 77
9654512
数据库标识符。使用此URL在反垃圾中连接到此实例的网页:http://www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=9654512
Reactome
R-HSA-9654512
1
Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9654512.1
1
Reactome数据库ID Release 77
9654515
数据库标识符。使用此URL在反弹中连接到此实例的网页:http://www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=9654515
Reactome
r - hsa - 9654515
1
Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9654515.1
s-farn-me kras4b:calm1:4xca2 +:pde6d:arl2:gtp
Reactome DB_ID: 9654518
1
1
Reactome数据库ID Release 77
9654518
数据库标识符。使用此URL将此实例的网页连接到Reactome:http://www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=9654518
Reactome
R-HSA-9654518
1
Reactome稳定的标识符。使用此URL连接到该实例的网页中Reactome://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9654518.1
Reactome数据库ID Release 77
9654523
数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9654523
Reactome
r - hsa - 9654523
1
Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9654523.1
21170358
Pubmed
2010
内吞分选和循环需要TAT-1/CHAT-1维持膜磷脂酰丝氨酸不对称
陈保会
江,岳
曾,盛
燕,Jiacong
李昕
张,Y
邹,魏
王,小陈
Plos Genet。6:e1001235
24725411
Pubmed
2014
KRA通过溶解,捕获和覆膜运输的空间循环定位于血浆膜
施米克,马尔特
Vartak, Nachiket
Papke,比约恩
Kovacevic,Marija.
Truxius,蒂娜C
Rossmannek,Lisaweta
巴斯蒂安,菲利普
细胞157:459 - 471
25759176
Pubmed
2015
拉斯采取行动保持原地不动
施米克,马尔特
Kraemer,阿斯特丽德
巴斯蒂安,菲利普
趋势细胞生物学25:190-7
22002721
Pubmed
2011
ARL2-GTP和ARL3-GTP调节FARNESYLADED货物的GDI运输系统
伊斯梅尔,Shehab
陈泳祥
Rusinova,亚历山德拉
钱德拉,Anchal
Bierbaum,Martin.
Gremer,洛萨
特里奥拉,杰玛
瓦尔德曼,赫伯特
巴斯蒂安,菲利普
Wittinghofer,A.
Nat,化学。生物7:942-9