BioPAX pathway converted from "rRNA modification in the mitochondrion" in the Reactome database. rRNA modification in the mitochondrion Five modified nucleotides have been detected in the 12S rRNA: 5-methylcytidine-841 catalyzed by NSUN4, 6-dimethyladenosine-936 catalyzed by TFB1M, 6-dimethyladenosine-937 catalyzed by TFB1M, 5-methyluridine-429, and 4-methylcytidine-839 (reviewed in Van Haute et al. 2015). Four modified nucleotides have been detected in 16S rRNA: 2'-O-methylguanosine-1145 catalyzed by MRM1, 2'-O-methylguanosine-1370 catalyzed by RNMTL1 (MRM3), 2'-O-methyluridine-1369 catalyzed by FTSJ2 (MRM2), and pseudouridine-1397. 2'-O-methyluridine-1369 and 2'-O-methylguanosone-1370 occur in the A-loop of rRNA which is located at the peptidyl transferase center of the large subunit. Here the modified residues play a role in interaction with the aminoacyl site of tRNA. Knockouts of TFB1M and NSUN4 are lethal in mice and mutations in TFB1M may be related to aminoglycoside-induced deafness (reviewed in Van Haute et al. 2015). Authored: May, Bruce, 2015-08-28 Reviewed: Bogenhagen, Daniel F, 2016-04-25 Edited: May, Bruce, 2015-08-28 LEFT-TO-RIGHT 2.1.1 NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841 MTERF4 forms a complex with NSUN4 (Camara et al. 2011, Spahr et al. 2012, Yakubovskaya et al. 2012) and recruits NSUN4 to the ribosome where NSUN4 transfers a methyl group from S-adenosylmethionine to the 5 position of cytidine-841 in 12S rRNA (Camara et al. 2011). Knockout of MTERF4 in mice is lethal and cardiomyocyte-specific knockout is accompanied by mitochondrial cardiomyopathy (Camara et al. 2011). Authored: May, Bruce, 2015-08-28 Reviewed: Bogenhagen, Daniel F, 2016-04-25 Edited: May, Bruce, 2015-08-28 SAM AdoMet S-adenosyl-L-methionine S-adenosylmethionine Reactome DB_ID: 2162265 mitochondrial matrix GENE ONTOLOGY GO:0005759 S-adenosyl-L-methionine [ChEBI:15414] S-adenosyl-L-methionine ChEBI CHEBI:15414 Reactome Database ID Release 77 2162265 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=2162265 Reactome R-ALL-2162265 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2162265.5 Reactome //www.joaskin.com MT-RNR1 12S rRNA Reactome DB_ID: 6792974 ENSEMBL:ENST00000389680 MT-RNR1 Mitochondrial 12S rRNA MT-RNR1 Homo sapiens NCBI Taxonomy 9606 ENSEMBL ENST00000389680 Reactome Database ID Release 77 6792974 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6792974 Reactome R-HSA-6792974 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6792974.1 SAH AdoHcy S-adenosyl-L-homocysteine S-adenosylhomocysteine Reactome DB_ID: 2162252 S-adenosyl-L-homocysteine [ChEBI:16680] S-adenosyl-L-homocysteine ChEBI CHEBI:16680 Reactome Database ID Release 77 2162252 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=2162252 Reactome R-ALL-2162252 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2162252.4 MT-RNR1 12S rRNA containing 5-methylC-841 12S rRNA containing 5-methylcytosine-841 Reactome DB_ID: 6793078 Reactome Database ID Release 77 6793078 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793078 Reactome R-HSA-6793078 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793078.2 ChEBI 74483 additional information MI MI:0361 ACTIVATION activeUnit: #实验研究 MTERF4:NSUN4 Reactome DB_ID: 6793090 MTERF4 Transcription termination factor 4, mitochondrial MTEF4_HUMAN Reactome DB_ID: 6793089 UniProt:Q7Z6M4 MTERF4 MTERF4 MTERFD2 HSPC096 FUNCTION Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).SUBUNIT Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit.DOMAIN The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction.PTM The mature mitochondrial protein exists in 2 forms differing at the level of their N-terminus, one is starting at residue 43 and the other at residue 48.SIMILARITY Belongs to the mTERF family. UniProt Q7Z6M4 43 EQUAL 381 EQUAL Reactome Database ID Release 77 6793089 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793089 Reactome R-HSA-6793089 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793089.2 1 NSUN4 5-methylcytosine rRNA methyltransferase NSUN4 ecNumber2.1.1.-/ecNumber NSUN4_HUMAN Reactome DB_ID: 6793068 UniProt:Q96CB9 NSUN4 NSUN4 FUNCTION Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. UniProt Q96CB9 26 EQUAL 384 EQUAL Reactome Database ID Release 77 6793068 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793068 Reactome R-HSA-6793068 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793068.2 1 Reactome Database ID Release 77 6793090 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793090 Reactome R-HSA-6793090 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793090.2 GENE ONTOLOGY GO:0009383 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 77 6793074 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793074 Reactome Database ID Release 77 6793057 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793057 Reactome R-HSA-6793057 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793057.3 23022348 Pubmed 2012 Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification Yakubovskaya, Elena Guja, Kip E Mejia, Edison Castano, Steven Hambardjieva, Elena Choi, Woo Suk Garcia-Diaz, Miguel Structure 20:1940-7 21531335 Pubmed 2011 MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome Cámara, Yolanda Asin-Cayuela, Jorge Park, Chan Bae Metodiev Metodi D Shi, Yonghong Ruzzenente, Benedetta Kukat, Christian Habermann, Bianca Wibom, Rolf Hultenby, Kjell Franz, Thomas Erdjument-Bromage, H Tempst, P Hallberg, B Martin Gustafsson, CM Larsson, Nils-Göran Cell Metab. 13:527-39 22949673 Pubmed 2012 Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis Spåhr, Henrik Habermann, Bianca Gustafsson, CM Larsson, Nils-Göran Hallberg, B Martin Proc. Natl. Acad. Sci. U.S.A. 109:15253-8 GENE ONTOLOGY GO:0031167 gene ontology term for cellular process MI MI:0359 LEFT-TO-RIGHT 2.1.1 TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 TFB1M transfers methyl groups from S-adenosylmethionine to the 6 position of adenosine residues at nucleotides 936 and 937 in 12S mitochondrial rRNA (McCulloch et al. 2002, Seidel-Rogol et al. 2003, Cotney et al. 2009, Guja et al. 2013). The mitochondrial RNA polymerase POLRMT associates directly with TFB1M and increases its methylase activity (Surovtseva and Shadel 2013). Alleles of TFB1M modify the severity of hearing loss associated with the A1555G mutation in 12S rRNA (Bykhovskaya et al. 2004). The A1555G mutation may cause hypermethylation of 12S rRNA which activates AMP kinase, E2F1, and apoptosis (Cotney et al. 2009, Raimundo et al. 2012), however the reported hypermethylation and deafness phenotype have been questioned (Lee et al. 2015). Disruption of Tfb1m in mice is lethal and causes loss of adenine methylation of the 12S RNA (Metodiev et al. 2009). Authored: May, Bruce, 2015-08-28 Reviewed: Bogenhagen, Daniel F, 2016-04-25 Edited: May, Bruce, 2015-08-28 4 4 MT-RNR1 12S rRNA containing 6-dimethylA-936,937 12S rRNA containing 6-dimethyladenosine-936 and 6-dimethyladenosine-937 Reactome DB_ID: 6793060 Reactome Database ID Release 77 6793060 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793060 Reactome R-HSA-6793060 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793060.2 ACTIVATION TFB1M Dimethyladenosine transferase 1, mitochondrial TFB1M_HUMAN Reactome DB_ID: 1592207 UniProt:Q8WVM0 TFB1M TFB1M CGI-75 FUNCTION S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.SUBUNIT Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.TISSUE SPECIFICITY Ubiquitously expressed.INDUCTION By the nuclear respiratory factors NRF1 and NRF2/GABPB2 and PGC-1 coactivators.DISEASE Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily. UniProt Q8WVM0 28 EQUAL 346 EQUAL Reactome Database ID Release 77 1592207 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=1592207 Reactome R-HSA-1592207 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1592207.1 GENE ONTOLOGY GO:0000179 Reactome Database ID Release 77 6793073 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793073 Reactome Database ID Release 77 6793066 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793066 Reactome R-HSA-6793066 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793066.3 23804760 Pubmed 2013 Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1 Guja, Kip E Venkataraman, Krithika Yakubovskaya, Elena Shi, Hui Mejia, Edison Hambardjieva, Elena Karzai, A Wali Garcia-Diaz, Miguel Nucleic Acids Res. 41:7947-59 11809803 Pubmed 2002 A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine McCulloch, V Seidel-Rogol, BL Shadel, GS Mol Cell Biol 22:1116-25 22341444 Pubmed 2012 Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness Raimundo, Nuno Song, Lei Shutt, Timothy E McKay, Sharen E Cotney, Justin Guan, Min-Xin Gilliland, Thomas C Hohuan, David Santos-Sacchi, Joseph Shadel, Gerald S Cell 148:716-26 19356719 Pubmed 2009 12 s rRNA的甲基化是体内所必需的tability of the small subunit of the mammalian mitochondrial ribosome Metodiev Metodi D Lesko, Nicole Park, Chan Bae Cámara, Yolanda Shi, Yonghong Wibom, Rolf Hultenby, Kjell Gustafsson, CM Larsson, Nils-Göran Cell Metab. 9:386-97 26464487 Pubmed 2015 Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing Lee, Seungmin Rose, Simon Metodiev Metodi D Becker, Lore Vernaleken, Alexandra Klopstock, Thomas Gailus-Durner, Valerie Fuchs, Helmut Hrabě De Angelis, Martin Douthwaite, Stephen Larsson, Nils-Göran Hum. Mol. Genet. 24:7286-94 23303773 Pubmed 2013 Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis Surovtseva, Yulia V Shadel, Gerald S Nucleic Acids Res. 41:2479-88 19417006 Pubmed 2009 Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness Cotney, Justin McKay, Sharen E Shadel, Gerald S Hum. Mol. Genet. 18:2670-82 12496758 Pubmed 2003 Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop Seidel-Rogol, BL McCulloch, V Shadel, GS Nat Genet 33:23-4 15110318 Pubmed 2004 Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation Bykhovskaya, Yelena Mengesha, Emebet Wang, Dai Yang, Huiying Estivill, X Shohat, Mordechai Fischel-Ghodsian, Nathan Mol. Genet. Metab. 82:27-32 LEFT-TO-RIGHT MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370 MRM3 (RNMTL1) associates with the large mitochondrial ribosomal subunit and transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl group of guanosine-1370 of 16S rRNA (Lee et al. 2013, Lee and Bogenhagen 2014). Inactivation of RNMTL1 causes aberrant assembly of large ribosomal subunits, decreased mitochondrial translation, and respiratory incompetence (Rorbach et al. 2014). Authored: May, Bruce, 2015-08-29 Reviewed: Bogenhagen, Daniel F, 2016-04-25 Edited: May, Bruce, 2015-08-29 MT-RNR2 16S rRNA Reactome DB_ID: 6792998 ENSEMBL:ENST00000387347 MT-RNR2 Mitochondrial 16S rRNA MT-RNR2 ENSEMBL ENST00000387347 Reactome Database ID Release 77 6792998 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6792998 Reactome R-HSA-6792998 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6792998.1 MT-RNR2 16S rRNA containing 2'-O-methylG-1370 16S rRNA containing 2'-O-methylguanosine-1370 Reactome DB_ID: 6793086 Reactome Database ID Release 77 6793086 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793086 Reactome R-HSA-6793086 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793086.2 ChEBI 74445 ACTIVATION RNMTL1 fullName evidence="9"rRNA methyltransferase 3, mitochondrial ecNumber evidence="12 13"2.1.1.-/ecNumber MRM3_HUMAN Reactome DB_ID: 6793067 UniProt:Q9HC36 MRM3 MRM3 RNMTL1 HC90 -O-ri函数S-adenosyl-L-methionine-dependent 2”bose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.TISSUE SPECIFICITY Expressed at same level in normal liver and hepatocarcinoma.SIMILARITY Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. UniProt Q9HC36 41 EQUAL 420 EQUAL Reactome Database ID Release 77 6793067 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793067 Reactome R-HSA-6793067 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793067.2 GENE ONTOLOGY GO:0070039 Reactome Database ID Release 77 6793094 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793094 Reactome Database ID Release 77 6793096 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793096 Reactome R-HSA-6793096 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793096.3 24036117 Pubmed 2013 Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid Lee, Ken-Wing Okot-Kotber, Cynthia LaComb, Joseph F Bogenhagen, Daniel F J. Biol. Chem. 288:31386-99 25009282 Pubmed 2014 MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome Rorbach, Joanna Boesch, Pierre Gammage, Payam A Nicholls, Thomas J J Pearce, Sarah F Patel, Dipali Hauser, Andreas Perocchi, Fabiana Minczuk, Michal Mol. Biol. Cell 25:2542-55 25074936 Pubmed 2014 Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA) Lee, Ken-Wing Bogenhagen, Daniel F J. Biol. Chem. 289:24936-42 GENE ONTOLOGY GO:0000451 LEFT-TO-RIGHT 2.1.1 MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine MRM2 (FTSJ2)位于线粒体ν附近的焦点cleoids (Lee et al. 2013) transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl of uridine-1369 in 16S rRNA (Lee and Bogenhagen 2014, Rorbach et al. 2014). Inactivation of FTSJ2 causes aberrant assembly of large mitochondrial subunits, reduced mitochondrial translation, and respiratory incompetence (Rorbach et al. 2014). Authored: May, Bruce, 2015-08-30 Reviewed: Bogenhagen, Daniel F, 2016-04-25 Edited: May, Bruce, 2015-08-30 MT-RNR2 16S rRNA containing 2'-O-methylU-1369 16S rRNAcontaining 2'-O-methyluridine-1369 Reactome DB_ID: 6793117 Reactome Database ID Release 77 6793117 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793117 Reactome R-HSA-6793117 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793117.2 ChEBI 74478 ACTIVATION FTSJ2 fullName evidence="9"rRNA methyltransferase 2, mitochondrial ecNumber evidence="13"2.1.1.-/ecNumber MRM2_HUMAN Reactome DB_ID: 6793061 UniProt:Q9UI43 MRM2 MRM2 FJH1 FTSJ2 -O-ri函数S-adenosyl-L-methionine-dependent 2”bose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.TISSUE SPECIFICITY Widely expressed, with highest expression in muscle, placenta, and heart.SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. UniProt Q9UI43 19 EQUAL 246 EQUAL Reactome Database ID Release 77 6793061 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793061 Reactome R-HSA-6793061 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793061.2 GENE ONTOLOGY GO:0008650 Reactome Database ID Release 77 6793126 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793126 Reactome Database ID Release 77 6793127 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793127 Reactome R-HSA-6793127 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793127.3 LEFT-TO-RIGHT MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145 MRM1位于线粒体类核附近的焦点(Lee et al. 2013) transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl of guanosine-1145 in 16S rRNA (Lee and Bogenhagen 2014). Authored: May, Bruce, 2015-08-30 Reviewed: Bogenhagen, Daniel F, 2016-04-25 Edited: May, Bruce, 2015-08-30 MT-RNR2 16S rRNA containing 2'-O-methylG-1145 16S rRNA containing 2'-O-methylguanosine-1145 Reactome DB_ID: 6793123 Reactome Database ID Release 77 6793123 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793123 Reactome R-HSA-6793123 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793123.2 ChEBI 74445 ACTIVATION MRM1 fullName evidence="7"rRNA methyltransferase 1, mitochondrial ecNumber evidence="11"2.1.1.-/ecNumber MRM1_HUMAN Reactome DB_ID: 6793088 UniProt:Q6IN84 MRM1 MRM1 -O-ri函数S-adenosyl-L-methionine-dependent 2”bose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.SIMILARITY Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. UniProt Q6IN84 21 EQUAL 353 EQUAL Reactome Database ID Release 77 6793088 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793088 Reactome R-HSA-6793088 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793088.2 Reactome Database ID Release 77 6793124 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793124 Reactome Database ID Release 77 6793122 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793122 Reactome R-HSA-6793122 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793122.3 Reactome Database ID Release 77 6793080 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6793080 Reactome R-HSA-6793080 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6793080.3 26016801 Pubmed 2015 Mitochondrial transcript maturation and its disorders Van Haute, Lindsey Pearce, Sarah F Powell, Christopher A D'Souza, Aaron R Nicholls, Thomas J Minczuk, Michal J. Inherit. Metab. Dis. 38:655-80 22642575 Pubmed 2012 The post-transcriptional life of mammalian mitochondrial RNA Rorbach, Joanna Minczuk, Michal Biochem. J. 444:357-73 GENE ONTOLOGY GO:0000154