BioPAX途径由Reactome数据库中的“胰岛素样生长因子-2 mRNA结合蛋白(IGF2BPs/IMPs/VICKZs)结合RNA”转化而来。 胰岛素样生长因子-2mrna结合蛋白（IGF2BPs/IMPs/VICKZs）结合RNA 胰岛素样生长因子-2mrna结合蛋白（IGF2BPs）结合特定的RNA并调节其翻译、稳定性和亚细胞定位。IGF2BP1、IGF2BP2和IGF2BP3结合约8400个蛋白质编码转录本。靶RNA包含序列基序CAUH（其中H为A、U或C），IGFBPs的结合增加了靶RNA的稳定性。 发表于:《中国科学院院刊》2009-07-04 综述:Chao, JA, 2010-05-30 评论：歌手，RH，2010-05-30 编辑日期:May, B, 2009-07-04 左到右 IGF2BP1结合特异性RNA 胰岛素样生长因子mRNA结合因子-1（IGF2BP1，也称为ZBP1，CRD-BP，IMP1和VICKZ1）结合含有序列基序CAUH的几种特异性RNA（其中H是A，C或U）。结合导致RNA的稳定性和亚细胞定位。<含有引导件-3的IGF2 mRNA的同种型在5'UTR处的IGF2BP1结合，抑制翻译（IGF2的其他同种型是本要的）。
ZBP1（IGF2BP1）使用它的第三和第四kH结构域识别β肌动蛋白mRNA的3'UTR的前28个NTS。KH结构域被布置为抗并联伪二聚体，其特异性地识别位于该RNA序列中的二分元素。

MyC（C-Myc）和Beta-TRCP1 mRNA在称为编码区决定因素（CDR）的位点约束在消息的开放阅读框中。Myc mRNA的结合将其免于降解并增加其半衰期
CD44 mRNA在3'UTR中约束。
IGF2BP1还结合非编码，印迹H19 RNA。 发表于:《中国科学院院刊》2009-07-04 综述:Chao, JA, 2010-05-30 评论：歌手，RH，2010-05-30 编辑日期:May, B, 2009-07-04 从Reactome中的EntitySet转换而来 与IGF2BP1结合的rna IGF2BP1结合的RNA分子（IMP1、CRD-BP、ZBP1、VICKZ1） Reactome DB_ID: 428308 igf2 - 001 mRNA 胰岛素样生长因子-2 mRNA isoform 001 Reactome DB_ID: 428362 胞浆 基因本体论 去:0005829 Ensembl：ENST00000381406 IGF2 igf2 - 001 mRNA 胰岛素样生长因子-2001 mRNA IGF2 智人 NCBI分类学 9606. 运用 ENST00000381406. Reactome数据库ID版本77 428362 数据库标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428362 反应途径 r - hsa - 428362 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428362.1 反应途径 //www.joaskin.com IGF2-002 mRNA 胰岛素样生长因子-2 mRNA亚型002 Reactome DB_ID: 428307 ENSEMBL:ENST0000337883 IGF2 IGF2-002 mRNA 胰岛素样生长因子-2mrna IGF2 运用 ENST0000337883 Reactome数据库ID版本77 428307 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428307 反应途径 r - hsa - 428307 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428307.1 ACTB (1 - 1917) -肌动蛋白mRNA亚型001 反应数据库ID:428322 Ensembl：ENST00000331789 ACTB -肌动蛋白mRNA亚型001 ACTB. 运用 ENST0000331789 1 相等的 1917 相等的 Reactome数据库ID版本77 428322 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428322 反应途径 r - hsa - 428322 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428322.1 MYC mRNA 反应数据库ID:428380 ENSEMBL:ENST0000613283 MYC MYCMRNA亚型201 我的C 运用 ENST00000613283 Reactome数据库ID版本77 428380 数据库标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428380 反应途径 R-HSA-428380 2 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-428380.2 CD44 mRNA亚型201 反应数据库ID:428379 ENSEMBL:ENST0000263398 CD44 CD44 mRNA亚型201 CD44 运用 ENST00000263398 Reactome数据库ID版本77 428379 数据库标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428379 反应途径 R-HSA-428379 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428379.1 CD44 mRNA亚型202 Reactome DB_ID: 428347 ENSEMBL:ENST0000278385 CD44 CD44 mRNA亚型202 CD44 运用 ENST00000278385 Reactome数据库ID版本77 428347 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428347 反应途径 r - hsa - 428347 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428347.1 CD44 mRNA亚型203 反应数据库ID:428370 运用:ENST00000278386 CD44 CD44 mRNA亚型203 CD44 运用 ENST00000278386 Reactome数据库ID版本77 428370 数据库标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428370 反应途径 R-HSA-428370 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428370.1 CD44 mRNA亚型204 Reactome DB_ID: 428345 Ensembl：ENST00000279452 CD44 CD44 mRNA亚型204 CD44 运用 ENST00000279452 Reactome数据库ID版本77 428345 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428345 反应途径 r - hsa - 428345 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428345.1 CD44 mRNA亚型205 反应DB_ID：428290 运用:ENST00000352818 CD44 CD44 mRNA亚型205 CD44 运用 ENST00000352818. Reactome数据库ID版本77 428290 数据库标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id = 428290 反应途径 R-HSA-428290 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428290.1 H19非编码RNA 反应数据库ID:428386 运用:ENST00000252900段H19 H19非编码RNA H19 运用 ENST00000252900 Reactome数据库ID版本77 428386 数据库标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428386 反应途径 R-HSA-428386 1 反应稳定标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428386.1 Reactome数据库ID版本77 428308 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428308 反应途径 r - hsa - 428308 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428308.1 ZBP1 IGF2BP1 胰岛素样生长因子2 mRNA结合蛋白1 IF2B1_HUMAN CRD-BP 维克Z1 反应数据库ID:428366 UniProt: Q9NZI8 IGF2BP1 IGF2BP1 CRDBP 维克Z1 ZBP1 功能RNA结合因子促进靶转录物到细胞质蛋白-RNA复合物（MRNP）。这个转录本“笼”入mRNPs允许mRNA运输和短暂储存。它还调节目标转录本遇到翻译装置的速率和位置，并保护它们免受内切酶攻击或microrna介导的降解。在成人感觉神经元（相似性）中轴突再生所需的转录物的转运和翻译中起到直接作用。调节局部β-肌动蛋白/ ACTB mRNA翻译，是细胞极性，细胞迁移和神经突的关键方法。与核中的ActB mRNA共同转型相关联。该结合涉及ACTB mRNA 3'-UTR中的保守54-核苷酸元素，称为“ZIPCODE”。由此形成的RNP出口到细胞质，与电动机蛋白结合并沿着细胞骨架向细胞周边传送。在运输过程中，防止actB mRNA被翻译成蛋白质。当RNP复合物在血浆膜附近到达其目的地时，IGF2BP1磷酸化。 This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.SUBUNIT Can form homodimers and heterodimers with IGF2BP1 and IGF2BP3. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. During HCV infection, identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts (via the KH domains) with HIV-1 GAG (via the second zinc finger motif of NC). Associates (via the RRM domains and KH domains) with HIV-1 particles. Identified in a mRNP complex, composed of at least DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with DHX9, ELAVL2, HNRNPA2B1, HNRNPC, HNRNPH1, HNRNPU, IGF2BP2, ILF2, and YBX1. Interacts with FMR1. Component of a multisubunit autoregulatory RNP complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1/UNR. Directly interacts with PABPC1. Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP. Interacts with ELAVL4 in an RNA-dependent manner. Associates with microtubules and polysomes. Interacts with AGO1 and AGO2.TISSUE SPECIFICITY Mainly expressed in the embryo, including in fetal liver, fetal lung, fetal kidney, fetal thymus (at protein level). Also expressed follicles of ovary, as well as in gonocytes of testis, spermatogonia, semen, oocytes and placenta (at protein level). Expressed in various cancers, including testis and lung cancers (at protein level), as well as kidney, prostate and trachea cancers.INDUCTION May be up-regulated in response to CTNNB1/beta-catenin activation.DOMAIN Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules. KH3 and KH4 mediate association with the cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only KH2 NES is XPO1-dependent. Both NES may be redundant, since individual in vitro mutations do not affect subcellular location of the full-length protein. The 4 KH domains are important to suppress HIV-1 infectivity.PTM Phosphorylated. Phosphorylation may impair association with ACTB mRNA and hence abolishes translational repression (By similarity).SIMILARITY Belongs to the RRM IMP/VICKZ family. uniprot. Q9NZI8 1 相等的 577 相等的 Reactome数据库ID版本77 428366 数据库标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428366 反应途径 r - hsa - 428366 1 Reactome稳定的标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-428366.1 IGF2BP1:核糖核酸 Reactome DB_ID: 428327 1 1 Reactome数据库ID版本77 428327 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428327 反应途径 r - hsa - 428327 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-428327.1 Reactome数据库ID版本77 428296 数据库标识符。使用此URL将此实例的网页连接到反乐中：http：//www.reaconome.org/cgi-bin/eventbrowser?db=gk_current&id=428296 反应途径 R-HSA-428296 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428296.2 16778892 Pubmed 2006 CRD-BP介导betaTrCP1和c-myc mRNA的稳定响应-连环蛋白信号 Noubissi,颗 埃尔切瓦，我 Bhatia, N Shakoori, 乌戈尔科夫 刘杰 Minamoto，T. 罗斯,我 福克斯,SY Spiegelman，VS. 自然441:898-901 19029303 Pubmed 2009 igf2bp1相关细胞质rna对c-myc mRNA稳定性的控制 Weidensdorfer D 圣尔，N 波特 莱德尔,M Köhn，M 希尔霍恩 Buchmeier,年代 Wahle,埃尔 Huttelmaier,年代 RNA 15:104-15 12894594 Pubmed 2003 CRD-BP:一种c-Myc mRNA稳定蛋白，具有癌胎表达模式 埃尼迪斯,P Mahaira L Papadopoulou, 特谢拉,奥 海姆,年代 安徒生，JA Evangelou E 达夫尼，U Pandis N Trangas T 抗癌res 23：2179-83 15601260 Pubmed 2005 VICKZ蛋白：一个多功能的调节性RNA结合蛋白家族 Yisraeli, JK 生物细胞97:87-96 16541107 Pubmed 2006 RNA结合IMP促进细胞粘附和侵袭足形成 Vikesaa，J. 汉森，电视 Jønson, L 博,R 组合名称,嗯 克里斯汀森，J 尼尔森，FC EMBO J 25:1456 - 68 9891060 Pubmed 1999 胰岛素样生长因子II mRNA结合蛋白家族在发育后期抑制翻译 尼尔森，J 克里斯汀森，J 李克安德森，J 约翰森，啊 组合名称,嗯 尼尔森，FC 摩尔细胞生物学19:1262-70 11713986 Pubmed 2001 参与RNA贩运的IGF-II mRNA结合蛋白（IMP）的家族 尼尔森，FC 尼尔森，J 克里斯汀森，J Scand J clinical Lab Invest supl 234:93-9 17652133 Pubmed 2007 VICKZ蛋白通过其RNA结合活性介导细胞迁移 Oberman F 兰德,K 梅泽尔斯，Y 鲁宾斯坦，AM Yisraeli, JK RNA 13:1558 - 69 20371350 Pubmed 2010 利用PAR-CLIP在转录组范围内识别RNA结合蛋白和microRNA靶点 哈夫纳，M 兰德泰勒，M 汉堡,我 霍尔希德，M 豪瑟，J Berninger，P Rothballer, ascano m，jr 荣坎普，AC Munschauer, M 乌尔里希, 沃德尔 杜尔,年代 扎沃兰，M Tuschl,托马斯 第141单元：129-41 20080952 Pubmed 2010 ZBP1对β -肌动蛋白zipcode的识别诱导RNA循环 赵杰 Patskovsky Y Patel，V. 利维，M Almo，SC. 歌手,罗伯特 基因发展24:148-58 10875929 Pubmed 2000 H19 RNA结合胰岛素样生长因子II mRNA结合蛋白的四个分子 伦格，S 尼尔森，FC 尼尔森，J 李克安德森，J 组合名称,嗯 克里斯汀森，J 生物化学杂志275:29562-9 12024010. Pubmed 2002 编码区不稳定性决定因素中翻译暂停对c-myc mRNA衰减的调控 Lemm,我 罗斯,我 摩尔细胞生物学22:3959-69 左到右 IGF2BP2结合特异性RNA 胰岛素样生长因子mRNA结合因子-2（IGF2BP2，也称为IMP2和VICKZ2）结合含有序列基序CAUH（其中H为A、C或U）的几种特定RNA。结合导致RNA的稳定和亚细胞定位。
含有leader-3的IGF2 mRNA亚型在5'UTR处与IGF2BP2结合，抑制翻译（IGF2的其他亚型是组成性的）。
IGF2BP2可能是2型糖尿病的原因之一。 发表于:《中国科学院院刊》2009-07-04 综述:Chao, JA, 2010-05-30 评论：歌手，RH，2010-05-30 编辑日期:May, B, 2009-07-04 从Reactome中的EntitySet转换而来 与IGF2BP2结合的rna IGF2BP2（IMP2，VICKZ2）结合的RNA分子 Reactome DB_ID: 428328 Reactome数据库ID版本77 428328 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428328 反应途径 r - hsa - 428328 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-428328.1 IGF2BP2 胰岛素样生长因子2 mRNA结合蛋白2 if2b2_human. Reactome DB_ID: 428302 UniProt:Q9Y6M1 IGF2BP2 IGF2BP2 IMP2. VICKZ2 功能RNA结合因子促进靶转录物到细胞质蛋白-RNA复合物（MRNP）。这个转录本“笼”入mRNPs允许mRNA运输和短暂储存。它还调节目标转录物遇到翻译设备的速率和位置，并从内切核酸酶攻击或微小核糖介导的降解（通过相似性）。与胰岛素样生长因子2（IGF2）mRNA的5'-UTR结合。绑定是同种型的特异性。与β-肌动蛋白/ actB和MYC转录物结合。津株可以以RNA依赖性方式用IGF2BP1和IGF2BP3与IGF2BP1和IGF2BP3形成卤代聚物和芳寡糖。与HNRPD和IGF2BP1相互作用。用ELAVL1，DHX9和HNRNPU.Tissue特异性在卵母细胞中表达，小型和生长卵泡，LEYDIG细胞，精液和精液（蛋白质水平）的颗粒细胞表达。在睾丸癌（蛋白质水平）中表达。心脏，胎盘，骨骼肌，骨髓，结肠，肾，唾液腺，睾丸和胰腺表达弱。 Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.DOMAIN Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.MISCELLANEOUS Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.SIMILARITY Belongs to the RRM IMP/VICKZ family. uniprot. Q9Y6M1 1 相等的 599. 相等的 Reactome数据库ID版本77 428302 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428302 反应途径 R-HSA-428302 1 反应稳定标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428302.1 IGF2BP2：RNA. Reactome DB_ID: 428335 1 1 Reactome数据库ID版本77 428335 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428335 反应途径 r - hsa - 428335 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428335.1 Reactome数据库ID版本77 428293 数据库标识符。使用此URL在反垃圾中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=428293 反应途径 R-HSA-428293 2 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-428293.2 18618095 Pubmed 2008 CDKAL1和IGF2BP2的变异影响高血糖钳夹期间第一阶段胰岛素分泌 groenewoud，mj. 德克尔，JM 弗里奇 reiling，E. Nijpels，G Heine，RJ. 马森，JA Machicao F Schäfer，SA 哈林,汉斯 LM, t哈特 van haeften，tw Diabetologia 51:1659 - 63 19429674 Pubmed 2009 IGF2 mRNA结合蛋白2-生物学功能和在2型糖尿病中的可能作用 克里斯汀森，J Kolte, 汉森，T. 尼尔森，F J摩尔内分泌素 左到右 IGF2BP3结合特异性RNA 胰岛素样生长因子mRNA结合因子-3 (IGF2BP3，也称为IMP3和VICKZ3)结合几种含有序列基元CAUH(其中H为A、C或U)的特定RNA。结合导致RNA的稳定和亚细胞定位。
含有leader-3的IGF2 mRNA亚型在5' UTR与IGF2BP3结合，抑制翻译(其他IGF2亚型是构成型)。 发表于:《中国科学院院刊》2009-07-04 综述:Chao, JA, 2010-05-30 评论：歌手，RH，2010-05-30 编辑日期:May, B, 2009-07-04 从Reactome中的EntitySet转换而来 与IGF2BP3结合的rna 与IGF2BP3结合的RNA分子(IMP3,VICKZ3) 反应数据库ID:428384 Reactome数据库ID版本77 428384 数据库标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428384 反应途径 R-HSA-428384 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428384.1 IGF2BP3 胰岛素样生长因子2 mRNA结合蛋白3 if2b3_human. Reactome DB_ID: 428313 UniProt: O00425 IGF2BP3 IGF2BP3 IMP3. KOC1 VICKZ3 功能rna结合因子，可将靶转录本募集到细胞质蛋白- rna复合物(mRNPs)。这个转录本“笼”入mRNPs允许mRNA运输和短暂储存。它还调节目标转录本遇到翻译装置的速率和位置，并保护它们免受内切酶攻击或microrna介导的降解。结合CD44 mRNA的3'-UTR并使其稳定，从而促进细胞黏附和肿瘤细胞浸润形成。结合-肌动蛋白/ACTB和MYC转录本。与胰岛素样生长因子2（IGF2）mRNA的5'-UTR结合。亚基可与IGF2BP1和IGF2BP3以rna依赖的方式形成均低聚体和异质低聚体。与IGF2BP1交互。与ELAVL1、DHX9和HNRNPU相互作用。胎肝、胎肺、胎肾、胎胸腺、胎胎盘、胎卵巢卵泡和睾丸的性腺细胞、生长中的卵母细胞、精原细胞和精液(蛋白水平)表达。 Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.DOMAIN All KH domains contribute binding to target mRNA. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.MISCELLANEOUS Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas.SIMILARITY Belongs to the RRM IMP/VICKZ family. uniprot. O00425 1 相等的 579 相等的 Reactome数据库ID版本77 428313 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428313 反应途径 r - hsa - 428313 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428313.1 IGF2BP3:核糖核酸 Reactome DB_ID: 428310 1 1 Reactome数据库ID版本77 428310 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428310 反应途径 r - hsa - 428310 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428310.1 Reactome数据库ID版本77 428287 数据库标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=428287 反应途径 R-HSA-428287 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428287.2 Reactome数据库ID版本77 428359 数据库标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428359 反应途径 r - hsa - 428359 3. Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428359.3 基因本体论 去：0043488 细胞过程的基因本体论术语 心肌梗死 MI：0359