BioPAX途径由Reactome数据库中的“TRKA受体激活”转化而来。 Trka受体的激活 Trk受体既可以被神经营养因子激活，也可以被两个g蛋白偶联受体(GPCRs)激活，但GPCRs的生物学相关性尚有待证实。 作者:Nasi, Sergio, Annibali, D, 2006-10-10 评论:格林，洛杉矶，2007-11-08 15:39:37 编辑:Jassal, Bijay, 2006-10-10 NGF激活TRKA 神经营养因子的功能是通过分泌的神经营养因子同型二聚体与它们共同的神经营养因子受体p75NTR和同源的原肌球蛋白相关激酶(TRK)受体结合介导的。NGF结合TRKA, BDNF和NT4结合TRKB, NT3结合TRKC。三分子信号复合物(NGF-p75NTR-TRKA)也可能存在。 作者:Nasi, Sergio, Annibali, D, 2006-10-10 评论:格林，洛杉矶，2007-11-08 15:39:37 编辑:Jassal, Bijay, 2006-10-10 从左到右 - ngf二聚体与TrkA受体结合 神经营养因子二聚体与TRK受体结合导致受体二聚。虽然NGF对TRK和p75NTR的解离常数非常相似，但结合动力学却截然不同:NGF与p75NTR的结合和解离比与TRKA的结合要快得多。p75NTR调控神经营养因子激活TRK受体的亲和性和特异性。它的存在需要观察到与TRK受体的高亲和力结合，因为它增加了神经营养因子与TRK蛋白的结合率。TRK受体中主要的配体结合域是膜近端Ig2 - c2样结构域(命名为Ig2结构域或结构域5)，尽管TRK胞外结构域中的其他区域对配体结合也很重要。
神经营养因子的N端在控制结合特异性方面很重要，该区域的结构在与TRK受体结合后重组。在一些神经元中，TRK受体在信号缺失时定位于细胞内囊泡。电活动、cAMP和Ca2+刺激TRK通过胞浆膜泡的胞外排泄进入细胞表面。在轴突末端，TRK受体在配体结合后进行配体依赖的内吞作用。内化的神经营养因子- trk复合物随后被分类并进入循环或逆行运输途径 作者:Nasi, Sergio, Annibali, D, 2006-10-10 编辑:Jassal, Bijay, 2006-10-10 NTRK1 高亲和力神经生长因子受体 ntrk1_human. 反应DB_ID：3008784 等离子体膜 基因本体论 去:0005886 UniProt: P04629 NTRK1 NTRK1 矿渣MTC 载重汽车 Trka. FUNCTION受体酪氨酸激酶参与开发和中枢和外周神经系统的通过增殖，分化和交感神经和神经神经元的存活的调节成熟。对NGF的高亲和力受体，其是其主配体（PUBMED：1850821，PUBMED：1849459，PUBMED：1281417，PUBMED：8325889，PUBMED：15488758，PUBMED：22649032，PUBMED：17196528，PUBMED：27445338）。还可以结合和通过NTF3 /神经营养因子-3激活。然而，NTF3只支持通过NTRK1轴突扩展，但对神经元的存活（通过相似性）没有影响。当NGF二聚体配体结合，经过同二聚化，自磷酸化和活化（PUBMED：1281417）。新兵，磷酸化和/或激活多个下游效应包括SHC1，FRS2，SH2B1，SH2B2和PLCG1调节不同的重叠信号传导级联驱动细胞存活和分化。通过SHC1和FRS2激活GRB2-RAS-MAPK级联反应，调节细胞分化和存活。通过PLCG1控制NF-κ-B启动和参与细胞存活的基因的转录。通过SHC1和SH2B1控件的Ras-PI3激酶AKT1信令级联，其也调节存活。在不存在配体和激活的，可以促进细胞死亡，使得依赖于营养factors.ACTIVITY规神经元的存活的促存活信号传导在神经元中的NTRK1效果需要其的内吞作用进入信令早期内涵体和它的逆行轴突运输。 This is regulated by different proteins including CFL1, RAC1 and SORT1. NTF3 is unable to induce this signaling probably due to the lability of the NTF3-NTRK1 complex in endosomes. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades (By similarity). Regulated by NGFR (By similarity).SUBUNIT Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Homodimerization is induced by binding of a NGF dimer (PubMed:1281417, PubMed:10490030, PubMed:17196528). Interacts with SQSTM1; bridges NTRK1 to NGFR (PubMed:11244088). Forms a ternary complex with NGFR and KIDINS220; this complex is affected by the expression levels of KIDINS220 and an increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with SH2D1A; regulates NTRK1 (By similarity). Interacts (phosphorylated upon activation by NGF) with SHC1; mediates SHC1 phosphorylation and activation (PubMed:8155326, PubMed:15488758). Interacts (phosphorylated upon activation by NGF) with PLCG1; mediates PLCG1 phosphorylation and activation (PubMed:7510697, PubMed:15488758). Interacts (phosphorylated) with SH2B1 and SH2B2 (By similarity). Interacts with GRB2 (PubMed:15488758). Interacts with PIK3R1 (PubMed:15488758). Interacts with FRS2 (PubMed:15488758). Interacts with SORT1; may regulate NTRK1 anterograde axonal transport (PubMed:21102451). Interacts with RAB7A (By similarity). Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner (By similarity). Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation (By similarity). Interacts with PTPRS (By similarity). Interacts with USP36; USP36 does not deubiquitinate NTRK1 (PubMed:27445338). Interacts with GGA3 (PubMed:26446845).TISSUE SPECIFICITY Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.INDUCTION Isoform TrkA-III is up-regulated upon hypoxia in cells normally expressing it.DOMAIN The transmembrane domain mediates interaction with KIDINS220.DOMAIN The extracellular domain mediates interaction with NGFR.PTM Ligand-mediated autophosphorylation (PubMed:2927393, PubMed:1281417, PubMed:15488758, PubMed:7510697, PubMed:8155326, PubMed:8325889, PubMed:27676246, PubMed:28177573). Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-496 mediates interaction and phosphorylation of SHC1 (PubMed:15488758, PubMed:7510697, PubMed:8155326, PubMed:8325889).PTM N-glycosylated (PubMed:2927393). Isoform TrkA-I and isoform TrkA-II are N-glycosylated.PTM Ubiquitinated (PubMed:27445338). Undergoes polyubiquitination upon activation; regulated by NGFR (PubMed:27445338). Ubiquitination by NEDD4L leads to degradation (PubMed:27445338). Ubiquitination regulates the internalization of the receptor (By similarity).DISEASE Chromosomal aberrations involving NTRK1 are found in papillary thyroid carcinomas (PTCs) (PubMed:2869410, PubMed:7565764, PubMed:1532241). Translocation t(1;3)(q21;q11) with TFG generates the TRKT3 (TRK-T3) transcript by fusing TFG to the 3'-end of NTRK1 (PubMed:7565764). A rearrangement with TPM3 generates the TRK transcript by fusing TPM3 to the 3'-end of NTRK1 (PubMed:2869410). An intrachromosomal rearrangement that links the protein kinase domain of NTRK1 to the 5'-end of the TPR gene forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the C-terminus of the NTRK1 protein (PubMed:1532241).MISCELLANEOUS Trk also stands for tropomyosin-related kinase since it was first isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 智人 NCBI分类法 9606 UniProt P04629 33 平等的 796 平等的 Reactome数据库ID Release 77 3008784 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=3008784 反应 r - hsa - 3008784 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3008784.1 反应 //www.joaskin.com 成熟beta-NGF为 Reactome DB_ID: 187031 细胞外区域 基因本体论 去:0005576 神经生长因子 神经生长因子 生成 Reactome DB_ID: 167034 UniProt: P01138神经生长因子 神经生长因子 NGFB 功能神经生长因子对交感神经和感觉神经系统的发育和维持具有重要作用(PubMed:14976160, PubMed:20978020)。NTRK1和NGFR受体的细胞外配体，激活细胞信号级联以调节神经元增殖、分化和存活(PubMed:20978020) (Probable)。未成熟的NGF前体(proNGF)作为SORCS2和NGFR形成的异二聚体受体的配体，激活细胞信号级联，导致RAC1和/或RAC2失活，肌动蛋白细胞骨架重组和神经元生长锥坍塌。与成熟NGF相比，前体形式(proNGF)促进神经元凋亡(在体外)(通过相似性)。抑制金属蛋白酶依赖的血小板糖蛋白VI的蛋白水解(PubMed:20164177)。结合溶血磷脂酰肌醇和溶血磷脂酰丝氨酸之间的两链同源二聚体。脂结合形式促进组胺从肥大细胞释放，与无脂形式相反(相似之处)。SUBUNIT Homodimer (PubMed:10490030, PubMed:15131306, PubMed:17196528)。同源二聚体与单个NTRK1链相互作用(PubMed:10490030, PubMed:17196528)。同源二聚体与单个NGFR链相互作用(PubMed:15131306)。NGF二聚体与单个SORCS2链相互作用(通过细胞外结构域)(通过相似性)。 The NGF precursor (proNGF) binds to a receptor complex formed by SORT1 and NGFR, which leads to NGF endocytosis. Both mature NGF and the immature NGF precursor (proNGF) interact with SORCS2 and with the heterodimer formed by SORCS2 and NGFR (via extracellular domains) (By similarity). The NGF precursor (proNGF) has much higher affinity for SORCS2 than mature NGF. The NGF precursor (proNGF) has much higher affinity for SORT1 than mature NGF (By similarity). Interacts with ADAM10 in a divalent cation-dependent manner (PubMed:20164177).SIMILARITY Belongs to the NGF-beta family. UniProt P01138 122 平等的 241 平等的 Reactome数据库ID Release 77 167034 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=167034 反应 r - hsa - 167034 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167034.1 2 Reactome数据库ID Release 77 187031 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187031 反应 r - hsa - 187031 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-187031.1 beta-NGF二聚体:TrkA受体 Reactome DB_ID: 166537 1 1 Reactome数据库ID Release 77 166537 数据库标识符。使用此URL将此实例的网页连接到反乐中：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id = 166537 反应 r - hsa - 166537 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-166537.2 Reactome数据库ID Release 77 166542 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=166542 反应 r - hsa - 166542 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-166542.1 1849459 Pubmed 1991 trk原癌基因编码神经生长因子受体 克莱恩,R 静，平​​等 Nanduri V O’rourke E Barbacid, M 细胞65:189 - 97 10490030 Pubmed 1999 神经生长因子与TrkA受体配体结合域的晶体结构 Wiesmann C Ultsch, MH 鲈鱼,上海 德沃斯,我 自然401:184-8 1850549 Pubmed 1991 trk原癌基因产物:神经生长因子的信号转导受体 卡普兰博士 Hempstead，BL. 马丁 - Zanca，D 超，Mv. Parada,低频 科学252:554-8 从左到右 结合的受体二聚 神经滋养蛋白与Trka受体的结合诱导其二聚化以形成受体同型二聚体。 作者:Nasi, Sergio, Annibali, D, 2006-10-10 编辑:Jassal, Bijay, 2006-10-10 - ngf二聚体:TrkA受体二聚体 Reactome DB_ID: 166543 1 1 Reactome数据库ID Release 77 166543 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=166543 反应 r - hsa - 166543 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-166543.2 Reactome数据库ID Release 77 166538 数据库标识符。使用此URL将此实例的网页连接到反乐中：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id = 166538 反应 r - hsa - 166538 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-166538.1 从左到右 2.7.10.1 Trka受体自动磷酸盐 NGF结合诱导TRKA的构象变化，这需要激活受体激酶结构域。TRK受体的激活会导致存在于每个受体胞浆结构域的10个进化保守酪氨酸中的几个磷酸化。激酶结构域激活环中的三个酪氨酸(TRKA中的Y670、Y674和Y675)的磷酸化增强了酪氨酸激酶的活性。TRKA Y490和Y785的磷酸化为含有SH2或PTB结构域的蛋白质创建了对接位点:Y490是SHC、FRS2和IRS1/2的对接位点，Y785与plc -1相互作用。另外三个酪氨酸残基对信号传递也很重要，但其作用机制尚不清楚。它们可能在受体中起结构作用。因此，TRKA受体的充分活性需要8个酪氨酸残基。
人类TRKA有两种亚型，分别为TRKA- I (790 a.a long)和TRKA- II (796 a.a long)。酪氨酸磷酸化位点编号为TRKA- I。TRK-II中的位点编号等于TRK-I编号+ 6(即TRK-I中的Y490对应TRK-II中的Y496，依此类推)。同样的修饰发生在大鼠TrkA的同源位点，也出现在两种亚型I和II中。
作者:Nasi, Sergio, Annibali, D, 2006-10-10 评论:格林，洛杉矶，2007-11-08 15:39:37 编辑:Jassal, Bijay, 2006-10-10 三磷酸腺苷 腺苷5 '三磷酸 ATP (4) Reactome DB_ID: 113592 cytosol. 基因本体论 去:0005829 ATP (4 -) (ChEBI: 30616) ATP (4) 三磷酸腺苷 三磷酸腺苷 腺苷5 '三磷酸 ChEBI CHEBI: 30616 Reactome数据库ID Release 77 113592 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113592 反应 r - - 113592 5 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 复合 C00002. 额外的信息 心肌梗死 小姐:0361 10 ADP. 腺苷5 '磷酸氢盐 ADP (3 -) Reactome DB_ID: 29370 ADP (3 -) (ChEBI: 456216) ADP (3 -) ADP. 事情就让它5,- o - [(phosphonatooxy) phosphinato]腺苷 ADP trianion ChEBI CHEBI: 456216 Reactome数据库ID Release 77 29370. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29370 反应 r - - 29370 5 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 复合 C00008 10 活化的Trka受体复合物 Reactome DB_ID: 166540 NTRK1 P-5Y-NTRK1 p-NTRK1 高亲和力神经生长因子受体 ntrk1_human. Reactome DB_ID: 3009413 490 平等的 O4'-磷酸-1-酪氨酸 国防部 国防部:00048 670 平等的 674 平等的 675 平等的 785 平等的 33 平等的 796 平等的 Reactome数据库ID Release 77 3009413 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=3009413 反应 r - hsa - 3009413 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3009413.1 2 beta-NGF为 Reactome DB_ID: 167057 2 Reactome数据库ID Release 77 167057 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=167057 反应 R-HSA-167057 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167057.1 1 Reactome数据库ID Release 77 166540 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=166540 反应 r - hsa - 166540 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-166540.1 激活 activeUnit: # Protein1 基因本体论 去:0004714 细胞功能的基因本体论术语 心肌梗死 小姐:0355 相同的催化剂活性 Reactome数据库ID Release 77 198204 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=198204 Reactome数据库ID Release 77 166544 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=166544 反应 r - hsa - 166544 1 Reactome稳定的标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-166544.1 从左到右 活化的Trka受体内化到内体 血浆膜的Trka通常导致快速的内吞作用和随后通过内体隔室网络的受体通过（Harrington等，2011; Wu等，2001）。 活化的Trka受体复合物 Reactome DB_ID: 190083 内体膜 基因本体论 去:0010008 p-5Y-NTRK1-1 磷酸化的Trka-1受体 p-5Y-NTRK1同种型1 Reactome DB_ID: 190064 UniProt: P04629-1 NTRK1 NTRK1 矿渣MTC 载重汽车 Trka. FUNCTION受体酪氨酸激酶参与开发和中枢和外周神经系统的通过增殖，分化和交感神经和神经神经元的存活的调节成熟。对NGF的高亲和力受体，其是其主配体（PUBMED：1850821，PUBMED：1849459，PUBMED：1281417，PUBMED：8325889，PUBMED：15488758，PUBMED：22649032，PUBMED：17196528，PUBMED：27445338）。还可以结合和通过NTF3 /神经营养因子-3激活。然而，NTF3只支持通过NTRK1轴突扩展，但对神经元的存活（通过相似性）没有影响。当NGF二聚体配体结合，经过同二聚化，自磷酸化和活化（PUBMED：1281417）。新兵，磷酸化和/或激活多个下游效应包括SHC1，FRS2，SH2B1，SH2B2和PLCG1调节不同的重叠信号传导级联驱动细胞存活和分化。通过SHC1和FRS2激活GRB2-RAS-MAPK级联反应，调节细胞分化和存活。通过PLCG1控制NF-κ-B启动和参与细胞存活的基因的转录。通过SHC1和SH2B1控件的Ras-PI3激酶AKT1信令级联，其也调节存活。在不存在配体和激活的，可以促进细胞死亡，使得依赖于营养factors.ACTIVITY规神经元的存活的促存活信号传导在神经元中的NTRK1效果需要其的内吞作用进入信令早期内涵体和它的逆行轴突运输。 This is regulated by different proteins including CFL1, RAC1 and SORT1. NTF3 is unable to induce this signaling probably due to the lability of the NTF3-NTRK1 complex in endosomes. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades (By similarity). Regulated by NGFR (By similarity).SUBUNIT Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Homodimerization is induced by binding of a NGF dimer (PubMed:1281417, PubMed:10490030, PubMed:17196528). Interacts with SQSTM1; bridges NTRK1 to NGFR (PubMed:11244088). Forms a ternary complex with NGFR and KIDINS220; this complex is affected by the expression levels of KIDINS220 and an increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with SH2D1A; regulates NTRK1 (By similarity). Interacts (phosphorylated upon activation by NGF) with SHC1; mediates SHC1 phosphorylation and activation (PubMed:8155326, PubMed:15488758). Interacts (phosphorylated upon activation by NGF) with PLCG1; mediates PLCG1 phosphorylation and activation (PubMed:7510697, PubMed:15488758). Interacts (phosphorylated) with SH2B1 and SH2B2 (By similarity). Interacts with GRB2 (PubMed:15488758). Interacts with PIK3R1 (PubMed:15488758). Interacts with FRS2 (PubMed:15488758). Interacts with SORT1; may regulate NTRK1 anterograde axonal transport (PubMed:21102451). Interacts with RAB7A (By similarity). Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner (By similarity). Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation (By similarity). Interacts with PTPRS (By similarity). Interacts with USP36; USP36 does not deubiquitinate NTRK1 (PubMed:27445338). Interacts with GGA3 (PubMed:26446845).TISSUE SPECIFICITY Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.INDUCTION Isoform TrkA-III is up-regulated upon hypoxia in cells normally expressing it.DOMAIN The transmembrane domain mediates interaction with KIDINS220.DOMAIN The extracellular domain mediates interaction with NGFR.PTM Ligand-mediated autophosphorylation (PubMed:2927393, PubMed:1281417, PubMed:15488758, PubMed:7510697, PubMed:8155326, PubMed:8325889, PubMed:27676246, PubMed:28177573). Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-496 mediates interaction and phosphorylation of SHC1 (PubMed:15488758, PubMed:7510697, PubMed:8155326, PubMed:8325889).PTM N-glycosylated (PubMed:2927393). Isoform TrkA-I and isoform TrkA-II are N-glycosylated.PTM Ubiquitinated (PubMed:27445338). Undergoes polyubiquitination upon activation; regulated by NGFR (PubMed:27445338). Ubiquitination by NEDD4L leads to degradation (PubMed:27445338). Ubiquitination regulates the internalization of the receptor (By similarity).DISEASE Chromosomal aberrations involving NTRK1 are found in papillary thyroid carcinomas (PTCs) (PubMed:2869410, PubMed:7565764, PubMed:1532241). Translocation t(1;3)(q21;q11) with TFG generates the TRKT3 (TRK-T3) transcript by fusing TFG to the 3'-end of NTRK1 (PubMed:7565764). A rearrangement with TPM3 generates the TRK transcript by fusing TPM3 to the 3'-end of NTRK1 (PubMed:2869410). An intrachromosomal rearrangement that links the protein kinase domain of NTRK1 to the 5'-end of the TPR gene forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the C-terminus of the NTRK1 protein (PubMed:1532241).MISCELLANEOUS Trk also stands for tropomyosin-related kinase since it was first isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. uniprot同种型 P04629.1. 490 平等的 670 平等的 674 平等的 675 平等的 785 平等的 33 平等的 796 平等的 Reactome数据库ID Release 77 190064 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=190064 反应 R-HSA-190064 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190064.2 2 beta-NGF为 Reactome DB_ID: 190067 神经生长因子 神经生长因子 生成 Reactome DB_ID: 190059 122 平等的 241 平等的 Reactome数据库ID Release 77 190059 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=190059 反应 r - hsa - 190059 2 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-190059.2 2 Reactome数据库ID Release 77 190067 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=190067 反应 R-HSA-190067 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190067.2 1 Reactome数据库ID Release 77 190083 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=190083 反应 r - hsa - 190083 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190083.2 Reactome数据库ID Release 77 190065 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=190065 反应 R-HSA-190065 4 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-190065.4 11466412 Pubmed 2001年 神经生长因子激活核内体中持续的Rap1信号 赖,CF 莫布里,厕所 J > 21:5406-16 21816277. Pubmed 2011年 TrkA核内体中肌动蛋白修饰物的招募支配NGF的逆行信号传导和存活 哈林顿,安东尼·W 圣Hillaire Coryse Zweifel,拉里年代 Glebova，Natalia o Philippidou, Polyxeni Halegoua,西蒙 Ginty David D 细胞146:421-34 Reactome数据库ID Release 77 187042 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187042 反应 r - hsa - 187042 1 Reactome稳定的标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-187042.1 1315923 Pubmed 1992 神经生长因子受体:一个调节神经营养蛋白家族作用的多组分系统 巴克,爸爸 墨菲,类风湿性关节炎 生物化学学报110:1-15 1844238 Pubmed 1991 癌基因和神经营养因子受体的trk家族 Lamballe，F. 克莱恩,R Barbacid, M 高松公主22:153-70 基因本体论 去:0048011 细胞过程的基因本体论术语 心肌梗死 小姐:0359 NGF-independant TRKA激活 Trk受体也可以通过至少两个G蛋白偶联的受体（GPCR），腺苷A2A受体和PACAP型I受体激活，而不会受到神经营养素。两种受体的活性由用于激活腺苷环化酶的G蛋白介导。这导致TRKA激活的导致尚未完全阐明，尽管SRC系列酪氨酸激酶和细胞内CA2似乎发挥作用。通过GPCRS的TRKA激活在细胞内位置（可能是GOLGI装置）中的缓慢动力学（需要超过1小时腺苷或PACAP处理），并且需要可能影响受体的处理和激活的转录和蛋白质合成事件。GPCR介导的Trk受体的反式激活导致AKT与ERKS的优先激活。这导致细胞存活反应。 作者:Nasi, Sergio, Annibali, D, 2006-10-10 编辑:Jassal, Bijay, 2006-10-10 从左到右 Ade-Rib结合AODORA2A和NTRK1,2 神经营养因子通过激活神经生长因子受体酪氨酸激酶(NTRKs)调节神经元细胞存活和突触可塑性。腺苷(Ade-Rib)是一种通过A2A受体(ADORA2A)发挥作用的神经调节剂，在缺乏神经营养因子的情况下可以转激活NTRKs (Jeanneteau & Chao 2006)。这种激活的机制尚不完全清楚。首先，Ade-Rib结合ADORA2A、NTRK1和NTRK2。 作者:Nasi, Sergio, Annibali, D, 2006-10-10 编辑:Jassal, Bijay, 2006-10-10 从Reactome中的EntitySet转换而来 NTRK1,2. 细胞内Trk受体 神经生长因子受体 神经营养酪氨酸激酶受体 Reactome DB_ID: 187658 NTRK1 高亲和力神经生长因子受体 ntrk1_human. Reactome DB_ID: 3008805 高尔基体膜 基因本体论 去:0000139 33 平等的 796 平等的 Reactome数据库ID Release 77 3008805 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=3008805 反应 r - hsa - 3008805 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa -3008805.1 NTRK2 BDNF/NT-3生长因子受体 NTRK2_HUMAN Reactome DB_ID: 3008801 UniProt: Q16620 NTRK2 NTRK2 TRKB. 功能受体酪氨酸激酶通过调节神经元的存活、增殖、迁移、分化和突触的形成和可塑性参与中枢和外周神经系统的发育和成熟(通过相似性)。BDNF/脑源性神经营养因子和NTF4/神经营养因子4受体。也可以结合NTF3/神经营养因子-3，后者激活受体的效率较低，但通过NTRK2调节神经元存活(PubMed:7574684, PubMed:15494731)。在配体结合时，经历同源二聚、自磷酸化和激活(PubMed:15494731)。招募、磷酸化和/或激活几个下游效应子，包括SHC1、FRS2、SH2B1、SH2B2和PLCG1，它们调节不同的重叠信号级联。通过SHC1, FRS2, SH2B1, SH2B2激活GRB2-Ras-MAPK级联，调控神经元分化，包括神经突起的生长。通过相同的效应体控制Ras-PI3激酶- akt1信号级联，主要调控生长和生存。通过PLCG1和下游蛋白激酶c调控的通路控制突触可塑性。因此，通过调节短期突触功能和长期增强，在学习和记忆中发挥作用。PLCG1还导致NF-Kappa-B激活和参与细胞生存的基因转录。 Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.ACTIVITY REGULATION The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity).SUBUNIT Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor (By similarity). Interacts with SORCS2; this interaction is important for normal targeting to post-synaptic densities in response to high-frequency stimulation (By similarity). Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway (PubMed:10092678). Interacts with APPL1 (By similarity). Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (By similarity). Interacts with SORL1; this interaction facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling (By similarity).TISSUE SPECIFICITY Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.DEVELOPMENTAL STAGE Widely expressed in fetal brain.PTM Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated.PTM Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).MISCELLANEOUS Trk also stands for tropomyosin-related kinase since the first Trk was isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. UniProt Q16620 32 平等的 822. 平等的 Reactome数据库ID Release 77 3008801 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=3008801 反应 r - hsa - 3008801 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3008801.1 Reactome数据库ID Release 77 187658 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187658 反应 R-HSA-187658 2 Reactome稳定的标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-187658.2 Ade-Rib ADENOCARD (TN) 腺苷 Reactome DB_ID: 83909 腺苷[Chebi：16335] 腺苷 ChEBI CHEBI: 16335 Reactome数据库ID Release 77 83909 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=83909 反应 r - - 83909 3. Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83909.3 复合 C00212 图 腺苷受体负责 AA2A_HUMAN Reactome DB_ID: 187668 UniProt: P29274图 图 Adora2. 腺苷的功能受体(通过相似性)。这种受体的活性是由G蛋白介导的，G蛋白激活腺苷酸环化酶(通过相似性)。亚基与USP4相互作用(通过细胞质c端结构域);互动是直接的(PubMed:16339847)。可能与DRD4作用(PubMed:18832607)。与NECAB2相互作用(PubMed:17689978)。(通过细胞质c端结构域)与GAS2L2相互作用;相互作用增强受体介导的腺苷环化酶活性(通过相似性)。胞质c端结构域对于将该蛋白的非泛素化形式靶向到细胞表面是必要的。天车Ubiquitinated。Deubiquitinated USP4;导致细胞表面的稳定和表达。SIMILARITY Belongs to the G-protein coupled receptor 1 family. UniProt P29274 1 平等的 412 平等的 Reactome数据库ID Release 77 187668 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187668 反应 R-HSA-187668 1 Reactome稳定的标识符。使用此URL将此实例的网页连接到反乐中：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-187668.1 Ade-Rib：Adora2a：ntrk1,2 Reactome DB_ID: 187653 1 1 1 Reactome数据库ID Release 77 187653 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187653 反应 R-HSA-187653 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-187653.2 Reactome数据库ID Release 77 187661 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187661 反应 R-HSA-187661 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-187661.2 从左到右 2.7.10 NTRK1,2在Ade-Rib中：adora2a：ntrk1,2自磷酸盐 神经营养因子通过激活神经生长因子受体酪氨酸激酶(NTRKs)调节神经元细胞存活和突触可塑性。腺苷(Ade-Rib)是一种通过A2A受体(ADORA2A)发挥作用的神经调节剂，在缺乏神经营养因子的情况下可以转激活NTRKs (Jeanneteau & Chao 2006)。这种激活的机制尚不完全清楚。在粘合剂 - 肋骨结合后：5个酪氨酸残基的Adora2a，ntrk1和ntrk2自磷酸盐酸盐。 作者:Nasi, Sergio, Annibali, D, 2006-10-10 编辑:Jassal, Bijay, 2006-10-10 5 5 Ade-Rib:图:p-5Y-NTRK1 p-5Y-NTRK2 Reactome DB_ID: 9612943 从Reactome中的EntitySet转换而来 p-5Y-NTRK1, p-5Y-NTRK2 细胞内磷酸化Trk受体 Reactome DB_ID: 187680 NTRK2 P-5Y-NTRK2 p-NTRK2 BDNF/NT-3生长因子受体 NTRK2_HUMAN Reactome DB_ID: 3008809 490 平等的 670 平等的 674 平等的 675 平等的 785 平等的 32 平等的 822. 平等的 Reactome数据库ID Release 77 3008809 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=3008809 反应 r - hsa - 3008809 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3008809.1 NTRK1 P-5Y-NTRK1 p-NTRK1 高亲和力神经生长因子受体 ntrk1_human. Reactome DB_ID: 3008810 33 平等的 796 平等的 Reactome数据库ID Release 77 3008810 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=3008810 反应 r - hsa - 3008810 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3008810.1 Reactome数据库ID Release 77 187680 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187680 反应 r - hsa - 187680 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-187680.2 1 1 1 Reactome数据库ID Release 77 9612943 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=9612943 反应 R-HSA-9612943 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9612943.1 激活 activeUnit: # Protein6 基因本体论 去:0004713 Reactome数据库ID Release 77 9613022 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9613022 Reactome数据库ID Release 77 9613023 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9613023 反应 r - hsa - 9613023 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa -9613023.1 16805430 Pubmed 2006年 GPCR配体促进神经营养作用 Jeanneteau F 超，Mv. 诺华发现Symp 276:181-9;讨论18 从左到右 Adcyap1（2-742）绑定Adcyap1R1和NTRK1,2 神经营养因子通过激活神经生长因子受体酪氨酸激酶(NTRKs)调节神经元细胞存活和突触可塑性。垂体腺苷酸环化酶激活多肽(ADCYAP1)是一种通过1型PACAP受体(ADCYAP1R1)起作用的神经调节剂，在缺乏神经营养因子的情况下可以转激活NTRKs (Jeanneteau & Chao 2006)。这种激活的机制尚不完全清楚。首先，ADCYAP1结合ADCYAP1R1和NTRK1和NTRK2。 作者:Nasi, Sergio, Annibali, D, 2006-10-10 编辑:Jassal, Bijay, 2006-10-10 Adcyap1. ADCYAP1 (2 - 742) 垂体腺苷酸环化酶激活多肽前体 PACA_HUMAN Reactome DB_ID: 187679 UniProt: P18509 ADCYAP1 Adcyap1. 与受体结合激活G蛋白，刺激垂体细胞腺苷酸环化酶。通过RAPGEF2/Rap1/B-Raf/ERK通路促进神经元投射发育。在嗜铬细胞中，诱导细胞内钙浓度和神经内分泌分泌的长期增加(相似)。参与葡萄糖稳态的控制，诱导胰腺β细胞分泌胰岛素(相似)。亚基与ADCYAP1R1相互作用(通过n端细胞外结构域)。属于胰高血糖素家族。 UniProt P18509. 2 平等的 742. 平等的 Reactome数据库ID Release 77 187679 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187679 反应 r - hsa - 187679 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-187679.1 ADCYAP1R1 垂体腺苷酸环化酶激活多肽I型受体 PACR_HUMAN Reactome DB_ID: 187664 UniProt: P41586 ADCYAP1R1 ADCYAP1R1 这是PACAP-27和PACAP-38的受体。这种受体的活性是由G蛋白介导的，G蛋白激活腺苷酸环化酶。可调节促肾上腺皮质激素、促黄体生成素、生长激素、催乳素、肾上腺素和儿茶酚胺的释放。可能在精子发生和精子运动中起作用。引起平滑肌松弛和胃肠道分泌。亚基(通过n端胞外结构域)与ADCYAP1相互作用。组织特异性脑内表达最多，肺、肝、胸腺、脾、胰腺和胎盘低表达。属于g蛋白偶联受体2家族。 UniProt P41586 21 平等的 468 平等的 Reactome数据库ID Release 77 187664 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187664 反应 R-HSA-187664 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-187664.1 PACAP:PACAP 1型受体 ADCYAP1 (2 - 742): ADCYAP1R1: NTRK1, 2 Reactome DB_ID: 9613001 1 1 1 Reactome数据库ID Release 77 9613001 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9613001 反应 r - hsa - 9613001 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9613001.1 Reactome数据库ID Release 77 187678 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187678 反应 r - hsa - 187678 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-187678.2 从左到右 2.7.10 NTRK1,2在ADCYAP1(2-742):ADCYAP1R1:NTRK1,2自磷酸化 神经营养因子通过激活神经生长因子受体酪氨酸激酶(NTRKs)调节神经元细胞存活和突触可塑性。垂体腺苷酸环化酶激活多肽(ADCYAP1)是一种通过1型PACAP受体(ADCYAP1R1)起作用的神经调节剂，可以在神经营养因子缺乏的情况下转激活NTRKs(它们自磷酸化)(Jeanneteau & Chao 2006)。这种激活的机制尚不完全清楚。 作者:Nasi, Sergio, Annibali, D, 2006-10-10 编辑:Jassal, Bijay, 2006-10-10 5 5 Adcyap1（2-742）：ADCYAP1R1：P-5Y-NTRK1，P-5Y-NTRK2 Reactome DB_ID: 9612944 1 1 1 Reactome数据库ID Release 77 9612944 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=9612944 反应 R-HSA-9612944 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-9612944.1 激活 activeUnit: # Protein6 Reactome数据库ID Release 77 9613038 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9613038 Reactome数据库ID Release 77 9612996. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9612996 反应 r - hsa - 9612996 1 Reactome稳定的标识符。使用此URL在反垃圾中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa -9612996.1 Reactome数据库ID Release 77 187024 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187024 反应 r - hsa - 187024 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-187024.2 基因本体论 去:0007190 Reactome数据库ID Release 77 187015 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=187015 反应 r - hsa - 187015 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-187015.2 16939974. Pubmed 2006年 Neurotrophin-regulated信号通路 Reichardt,低频 中国科学(d辑:地球科学 基因本体论 去:0007169