The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Cargo concentration in the ER This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp LEFT-TO-RIGHT SEC24A,B:SEC23A bind SEC22B This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp sec22 SEC22B Q9Y7L0 Reactome DB_ID: 10711405 endoplasmic reticulum membrane GENE ONTOLOGY GO:0005789 UniProt:Q9Y7L0 sec22 Schizosaccharomyces pombe NCBI Taxonomy 4896 UniProt Q9Y7L0 2 EQUAL 215 EQUAL Reactome Database ID Release 77 10711405 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711405 Reactome R-SPO-5688150 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688150.1 Reactome //www.joaskin.com sec231 SEC23A O74873 Reactome DB_ID: 10711472 cytosol GENE ONTOLOGY GO:0005829 UniProt:O74873 sec231 UniProt O74873 1 EQUAL 765 EQUAL Reactome Database ID Release 77 10711472 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711472 Reactome R-SPO-203972 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203972.1 sec24 SEC24A Q9UUI5 Reactome DB_ID: 10711536 UniProt:Q9UUI5 sec24 UniProt Q9UUI5 1 EQUAL 1093 EQUAL Reactome Database ID Release 77 10711536 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711536 Reactome R-SPO-203978 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203978.1 SEC24A,B:SEC23A:SEC22B Reactome DB_ID: 10723901 1 sec231 SEC23A O74873 Reactome DB_ID: 10711443 1 EQUAL 765 EQUAL Reactome Database ID Release 77 10711443 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711443 Reactome R-SPO-203976 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203976.1 1 1 Reactome Database ID Release 77 10723901 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723901 Reactome R-SPO-5694319 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694319.1 Reactome Database ID Release 77 10723903 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723903 Reactome R-SPO-5694415 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694415.1 Of the four human SEC24 isoforms, SEC24A and B are required for packaging the v-SNARE SEC22 into COPII vesicles. Recognition of the ER packaging epitope on SEC22 also depends on SEC23A (Mancias and Goldberg, 2007). 17499046 Pubmed 2007 The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope Mancias, Joseph D Goldberg, Jonathan Mol. Cell 26:403-14 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT SEC4C,D bind GOSR2 and STX5 This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Converted from EntitySet in Reactome SEC24C,D Reactome DB_ID: 10711470 SEC24C Q9USS7 Reactome DB_ID: 10711466 UniProt:Q9USS7 UniProt Q9USS7 1 EQUAL 1094 EQUAL Reactome Database ID Release 77 10711466 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711466 Reactome R-SPO-203988 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203988.1 SEC24D Q9USS7 Reactome DB_ID: 10711468 1 EQUAL 1032 EQUAL Reactome Database ID Release 77 10711468 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711468 Reactome R-SPO-203990 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203990.1 Reactome Database ID Release 77 10711470 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711470 Reactome R-SPO-5694201 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694201.1 Converted from EntitySet in Reactome GOSR2,STX5 Reactome DB_ID: 10711464 bos1 GOSR2 Q9P7G5 Reactome DB_ID: 10711457 UniProt:Q9P7G5 bos1 UniProt Q9P7G5 1 EQUAL 212 EQUAL Reactome Database ID Release 77 10711457 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711457 Reactome R-SPO-5689451 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5689451.1 sed5 STX5 O13644 Reactome DB_ID: 10711462 UniProt:O13644 sed5 UniProt O13644 1 EQUAL 355 EQUAL Reactome Database ID Release 77 10711462 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711462 Reactome R-SPO-5689474 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5689474.1 Reactome Database ID Release 77 10711464 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711464 Reactome R-SPO-5694232 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694232.1 SEC23A:SEC24C,D:GOSR2,STX5 Reactome DB_ID: 10711474 1 1 1 Reactome Database ID Release 77 10711474 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711474 Reactome R-SPO-5694245 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694245.1 Reactome Database ID Release 77 10723899 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723899 Reactome r -热点- 5694413 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694413.1 SEC24 isoforms C and D are required in conjunction with SEC23A for packaging the t-SNARES STX5 and GOSR2 into COPII vesicles for transport to the Golgi (Mancias and Goldberg, 2008). 18843296 Pubmed 2008 Structural basis of cargo membrane protein discrimination by the human COPII coat machinery Mancias, Joseph D Goldberg, Jonathan EMBO J. 27:2918-28 LEFT-TO-RIGHT Inner coat assembly and cargo binding This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp SAR1B:GTP Reactome DB_ID: 10711452 sar1 SAR1B Q01475 Reactome DB_ID: 10711450 UniProt:Q01475 sar1 UniProt Q01475 1 EQUAL 198 EQUAL Reactome Database ID Release 77 10711450 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711450 Reactome R-SPO-203995 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203995.1 1 GTP Guanosine 5'-triphosphate Reactome DB_ID: 29438 GTP [ChEBI:15996] GTP Guanosine 5'-triphosphate ChEBI CHEBI:15996 Reactome Database ID Release 77 29438 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29438 Reactome R-ALL-29438 3 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.3 COMPOUND C00044 additional information MI MI:0361 1 Reactome Database ID Release 77 10711452 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711452 Reactome R-SPO-204003 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204003.1 SEC23:SEC24 Reactome DB_ID: 10711542 1 Converted from EntitySet in Reactome SEC24 Reactome DB_ID: 10711540 Reactome Database ID Release 77 10711540 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711540 Reactome R-SPO-203991 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203991.1 1 Reactome Database ID Release 77 10711542 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711542 Reactome R-SPO-203975 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203975.1 COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 Reactome DB_ID: 10711476 1 SEC23:SEC24 Reactome DB_ID: 10711445 Converted from EntitySet in Reactome SEC24 Reactome DB_ID: 10711438 sec24 SEC24A Q9UUI5 Reactome DB_ID: 10711427 1 EQUAL 1093 EQUAL Reactome Database ID Release 77 10711427 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711427 Reactome R-SPO-203992 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203992.1 SEC24C Q9USS7 Reactome DB_ID: 10711434 1 EQUAL 1094 EQUAL Reactome Database ID Release 77 10711434 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711434 Reactome R-SPO-203987 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203987.1 SEC24D Q9USS7 Reactome DB_ID: 10711436 1 EQUAL 1032 EQUAL Reactome Database ID Release 77 10711436 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711436 Reactome R-SPO-204004 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204004.1 Reactome Database ID Release 77 10711438 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711438 Reactome R-SPO-203974 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203974.1 1 1 Reactome Database ID Release 77 10711445 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711445 Reactome R-SPO-204007 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204007.1 1 1 Reactome Database ID Release 77 10711476 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711476 Reactome R-SPO-5694523 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694523.1 Reactome Database ID Release 77 10724023 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10724023 Reactome R-SPO-5694522 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694522.1 SAR1:GTP recruits the cytoplasmic SEC23:SEC24 complex. SEC24, and to a lesser extent SEC23, also mediate interaction with COPII cargo, concentrating it into the emerging vesicle. Transmembrane cargo may interact directly with the inner coat proteins, often in an isoform specific manner; alternately, some transmembrane proteins and all soluble cargo interact first with a cargo receptor of the p24, LMAN or ERV families. 10825291 Pubmed 2000 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites Stephens, DJ Lin-Marq, N Pagano, A Pepperkok, R Paccaud, JP J Cell Sci 113:2177-85 10982397 Pubmed 2000 Dynamics of transitional endoplasmic reticulum sites in vertebrate cells Hammond, AT Glick, BS Mol Biol Cell 11:3013-30 Reactome Database ID Release 77 10733492 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10733492 Reactome R-SPO-5694530 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694530.1 Computational analysis suggests that ~25% of the proteome may be exported from the ER in human cells (Kanapin et al, 2003). These cargo need to be recognized and concentrated into COPII vesicles, which range in size from 60-90 nm, and which move cargo from the ER to the ERGIC in mammalian cells (reviewed in Lord et al, 2013; Szul and Sztul, 2011). Recognition of transmembrane cargo is mediated by interaction with one of the 4 isoforms of SEC24, a component of the inner COPII coat (Miller et al, 2002; Miller et al, 2003; Mossessova et al, 2003; Mancias and Goldberg, 2008). Soluble cargo in the ER lumen is concentrated into COPII vesicles through interaction with a receptor of the ERGIC-53 family, the p24 family or the ERV family. Each of these families of transmembrane receptors interact with cargo through their lumenal domains and with components of the COPII coat with their cytoplasmic domains and are packaged into the COPII vesicle along with the cargo. The receptors are subsequently recycled to the ER in COPI vesicles through retrograde traffic (reviewed in Dancourt and Barlowe, 2010). Packaging of large cargo such as fibrillar collagen depends on the transmembrane accessory factors MIA3 (also known as TANGO1) and CTAGE5. Like the ERGIC, p24 and ERV cargo receptors, MIA3 and MIA2 (also known as CTAGE5) interact both with the collagen cargo and with components of the COPII coat. Unlike the other cargo receptors, however, MIA3 and MIA2 are not loaded into the vesicle but remain in the ER membrane (reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015). 23378591 Pubmed 2013 The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi Lord, Christopher Ferro-Novick, Susan Miller, Elizabeth A Cold Spring Harb Perspect Biol 5: 25619253 Pubmed 2015 Procollagen export from the endoplasmic reticulum Malhotra, Vivek Erlmann, Patrik Nogueira, Cristina Biochem. Soc. Trans. 43:104-7 12819131 Pubmed 2003 Mouse proteome analysis Kanapin, Alexander Batalov, Serge Davis, Melissa J 高夫,朱利安 Grimmond, Sean Kawaji, Hideya Magrane, Michele Matsuda, Hideo Schönbach, Christian Teasdale, Rohan D Yuan, Zheng Genome Res. 13:1335-44 22013193 Pubmed 2011 COPII and COPI traffic at the ER-Golgi interface Szul, Tomasz Sztul, Elizabeth Physiology (Bethesda) 26:348-64 21878990 Pubmed 2011 Protein export at the ER: loading big collagens into COPII carriers Malhotra, V Erlmann, P EMBO J 30:3475-80 12941277 Pubmed 2003 Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles Miller, Elizabeth A Beilharz, Traude H Malkus, Per N Lee, Marcus C S Hamamoto, Susan Orci, L Schekman, Randy Cell 114:497-509 12426382 Pubmed 2002 Cargo selection into COPII vesicles is driven by the Sec24p subunit Miller, Elizabeth Antonny, Bruno Hamamoto, Susan Schekman, Randy EMBO J. 21:6105-13 20533886 Pubmed 2010 Protein sorting receptors in the early secretory pathway Dancourt, Julia Barlowe, Charles Annu. Rev. Biochem. 79:777-802 12941276 Pubmed 2003 SNARE selectivity of the COPII coat Mossessova,埃琳娜 Bickford, Lincoln C Goldberg, Jonathan Cell 114:483-95 COPII-mediated vesicle transport This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp LEFT-TO-RIGHT SAR1 Activation And Membrane Binding This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp SAR1B:GDP Reactome DB_ID: 10711526 GDP Guanosine 5'-diphosphate Guanosine diphosphate Reactome DB_ID: 29420 GDP [ChEBI:17552] GDP Guanosine 5'-diphosphate Guanosine diphosphate ChEBI CHEBI:17552 Reactome Database ID Release 77 29420 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29420 Reactome R-ALL-29420 2 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29420.2 COMPOUND C00035 1 sar1 SAR1B Q01475 Reactome DB_ID: 10711524 1 EQUAL 198 EQUAL Reactome Database ID Release 77 10711524 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711524 Reactome R-SPO-174678 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-174678.1 1 Reactome Database ID Release 77 10711526 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711526 Reactome R-SPO-203989 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203989.1 ACTIVATION PREB spo14 Q10659 Reactome DB_ID: 10711531 UniProt:Q10659 spo14 UniProt Q10659 1 EQUAL 417 EQUAL Reactome Database ID Release 77 10711531 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711531 Reactome R-SPO-203984 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203984.1 GENE ONTOLOGY GO:0005085 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 77 10711532 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711532 Reactome Database ID Release 77 10711534 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711534 Reactome R-SPO-203977 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203977.1 SAR1-GDP is recruited to the ER membrane by the transmembrane GEF (Guanine nucleotide exchange factor) PREB (also known as SEC12), where it is converted to SAR1-GTP. PREB itself is recruited to ER exit sites through interaction with MIA2 (also known as CTAGE5). 25202031 Pubmed 2014 Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export Saito, Kota Yamashiro, Koh Shimazu, Noriko Tanabe, Tomoya Kontani, Kenji Katada, Toshiaki J. Cell Biol. 206:751-62 LEFT-TO-RIGHT 3.6.5.4 3.6.5.3 3.6.5.2 3.6.5.1 Loss of SAR1B GTPase This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Pi Orthophosphate hydrogenphosphate Phosphate Inorganic Phosphate Reactome DB_ID: 29372 hydrogenphosphate [ChEBI:43474] hydrogenphosphate hydrogen phosphate phosphate (警察丙(OH)) (2) INORGANIC PHOSPHATE GROUP HYDROGENPHOSPHATE ION HPO4(2-) [P(OH)O3](2-) ChEBI CHEBI:43474 Reactome Database ID Release 77 29372 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29372 Reactome R-ALL-29372 4 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.4 COMPOUND C00009 ACTIVATION GENE ONTOLOGY GO:0003924 Reactome Database ID Release 77 10724024 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10724024 Reactome Database ID Release 77 10724026 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10724026 Reactome R-SPO-5694527 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694527.1 Sar1p-GTP hydrolysis is increased 15-30-fold by Sec23p. Sar1p-GDP is released as a result of this hydrolysis and used in further vesicle sculpting cycles. Sar1p-GTP hydrolysis occurs at two critical points during the cycle, first (as represented here) as a proofreading step, insuring that the cargo is loaded. Later in the cycle Sar1p-GTP hydrolysis triggers the uncoating of the budded vesicle. 17316621 Pubmed 2007 Mechanisms of COPII vesicle formation and protein sorting Sato, K Nakano, A FEBS Lett 581:2076-82 LEFT-TO-RIGHT SEC31:SEC13 and v-SNARE recruitment This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp SEC31A:SEC13:SEC23IP Reactome DB_ID: 10711400 sec13 SEC13 O94319 Reactome DB_ID: 10707230 UniProt:O94319 sec13 UniProt O94319 2 EQUAL 322 EQUAL Reactome Database ID Release 77 10707230 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10707230 Reactome R-SPO-203981 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203981.1 2 sec31 SEC31A O13637 Reactome DB_ID: 10711398 UniProt:O13637 sec31 UniProt O13637 1 EQUAL 1220 EQUAL Reactome Database ID Release 77 10711398 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711398 Reactome R-SPO-203983 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-203983.1 2 P87109 SEC23IP Reactome DB_ID: 10711393 UniProt:P87109 UniProt P87109 1 EQUAL 1000 EQUAL Reactome Database ID Release 77 10711393 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711393 Reactome R-SPO-5688156 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688156.1 1 Reactome Database ID Release 77 10711400 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711400 Reactome R-SPO-5694316 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694316.1 COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer Reactome DB_ID: 10711482 TFG hexamer Reactome DB_ID: 10711480 Ghost homologue of TFG Reactome DB_ID: 10711478 Reactome Database ID Release 77 10711478 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711478 Reactome R-SPO-5688159 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688159.1 6 Reactome Database ID Release 77 10711480 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711480 Reactome R-SPO-5694310 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694310.1 1 1 SEC16A:SEC16B Reactome DB_ID: 10711422 sec16 SEC16A O14029 Reactome DB_ID: 10711418 UniProt:O14029 sec16 UniProt O14029 1 EQUAL 2179 EQUAL Reactome Database ID Release 77 10711418 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711418 Reactome R-SPO-5685728 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5685728.1 1 sec16 SEC16B O14029 Reactome DB_ID: 10711420 1 EQUAL 1060 EQUAL Reactome Database ID Release 77 10711420 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711420 Reactome R-SPO-5685731 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5685731.1 1 Reactome Database ID Release 77 10711422 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711422 Reactome R-SPO-5694307 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694307.1 1 Reactome Database ID Release 77 10711482 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711482 Reactome R-SPO-5694339 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694339.1 Converted from EntitySet in Reactome ER-to-ERGIC v-SNARES Reactome DB_ID: 10711413 ykt6 PalmC-YKT6 O60073 Reactome DB_ID: 10711411 UniProt:O60073 ykt6 UniProt O60073 194 EQUAL S-palmitoyl-L-cysteine MOD MOD:00115 1 EQUAL 196 EQUAL Reactome Database ID Release 77 10711411 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711411 Reactome R-SPO-5688145 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688145.1 Reactome Database ID Release 77 10711413 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711413 Reactome R-SPO-5694335 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694335.1 COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES Reactome DB_ID: 10711484 1 1 1 Reactome Database ID Release 77 10711484 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711484 Reactome R-SPO-5694337 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694337.1 Reactome Database ID Release 77 10711548 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711548 Reactome R-SPO-204008 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204008.1 The outer coat proteins SEC13 and SEC31A are thought to exist in a cytosolic heterohexamer with SEC23IP and are recruited to the ER through interaction with pre-bound SEC23-SEC24 complexes (Stephens et al, 2000; Hammond and Glick, 2000; Ong et al, 2010; reviewed in Szul and Sztul, 2011). v-SNAREs such as the SEC22 proteins are also incorporated into the emerging vesicle through interactions with components of the COPII coat (Xu et al, 2000; Mancias and Goldberg, 2008; Gordon et al, 2010; reviewed in Szul and Sztul, 2011; Lord et al, 2013). 11035026 Pubmed 2000 Subunit structure of a mammalian ER/Golgi SNARE complex Xu, Dalu Joglekar, Ashwini P Williams, Antoinette L Hay, Jesse C J. Biol. Chem. 275:39631-9 20545907 Pubmed 2010 A targeted siRNA screen to identify SNAREs required for constitutive secretion in mammalian cells Gordon, David E Bond, Lisa M Sahlender, Daniela A Peden, Andrew A Traffic 11:1191-204 20679433 Pubmed 2010 p125A交货ists as part of the mammalian Sec13/Sec31 COPII subcomplex to facilitate ER-Golgi transport Ong, Yan Shan Tang, Bor Luen Loo, LS Hong, W J. Cell Biol. 190:331-45 LEFT-TO-RIGHT COPII coat binds TRAPPCII and RAB1:GDP This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp TRAPPCII Reactome DB_ID: 10723876 O74501 TRAPPC10 Reactome DB_ID: 10723837 UniProt:O74501 UniProt O74501 1 EQUAL 1259 EQUAL Reactome Database ID Release 77 10723837 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723837 Reactome R-SPO-5216159 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5216159.1 1 trs31 TRAPPC5 Q9P7N9 Reactome DB_ID: 10723862 UniProt:Q9P7N9 trs31 UniProt Q9P7N9 1 EQUAL 188 EQUAL Reactome Database ID Release 77 10723862 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723862 Reactome R-SPO-5683765 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5683765.1 1 Q09784 TRAPPC6A Reactome DB_ID: 10723872 UniProt:Q09784 UniProt Q09784 1 EQUAL 159 EQUAL Reactome Database ID Release 77 10723872 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723872 Reactome R-SPO-5685733 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5685733.1 1 bet3 TRAPPC3 Q9P6P5 Reactome DB_ID: 10723852 UniProt:Q9P6P5 bet3 UniProt Q9P6P5 1 EQUAL 180 EQUAL Reactome Database ID Release 77 10723852 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723852 Reactome R-SPO-5683761 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5683761.1 1 trs120 TRAPPC9 O14251 Reactome DB_ID: 10723867 UniProt:O14251 trs120 UniProt O14251 1 EQUAL 1148 EQUAL Reactome Database ID Release 77 10723867 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723867 Reactome R-SPO-5683770 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5683770.1 1 bet5 TRAPPC1 Q9UT70 Reactome DB_ID: 10723832 UniProt:Q9UT70 bet5 UniProt Q9UT70 1 EQUAL 145 EQUAL Reactome Database ID Release 77 10723832 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723832 Reactome R-SPO-5683750 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5683750.1 1 trs23 TRAPPC4 O43041 Reactome DB_ID: 10723857 UniProt:O43041 trs23 UniProt O43041 1 EQUAL 219 EQUAL Reactome Database ID Release 77 10723857 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723857 Reactome R-SPO-5683764 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5683764.1 1 O13732 TRAPPC2L Reactome DB_ID: 10723847 UniProt:O13732 UniProt O13732 1 EQUAL 140 EQUAL Reactome Database ID Release 77 10723847 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723847 Reactome R-SPO-5683759 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5683759.1 1 trs20 TRAPPC2 Q9USZ5 Reactome DB_ID: 10723842 UniProt:Q9USZ5 trs20 UniProt Q9USZ5 1 EQUAL 140 EQUAL Reactome Database ID Release 77 10723842 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723842 Reactome R-SPO-5683757 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5683757.1 1 Q09784 TRAPPC6B Reactome DB_ID: 10723874 1 EQUAL 158 EQUAL Reactome Database ID Release 77 10723874 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723874 Reactome R-SPO-5685735 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5685735.1 1 Reactome Database ID Release 77 10723876 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723876 Reactome R-SPO-5694315 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694315.1 RAB1:GDP Reactome DB_ID: 10723827 1 ypt1 RAB1A P11620 Reactome DB_ID: 10723823 UniProt:P11620 ypt1 UniProt P11620 2 EQUAL 205 EQUAL Reactome Database ID Release 77 10723823 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723823 Reactome R-SPO-5685725 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5685725.1 1 Reactome Database ID Release 77 10723827 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723827 Reactome R-SPO-5694296 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694296.1 COPII货物:受体:SEC23: SEC24: SEC13: SEC31: SEC23IP:v-SNAREs Reactome DB_ID: 10711522 ER to Golgi transport vesicle membrane GENE ONTOLOGY GO:0012507 Converted from EntitySet in Reactome ER-to-ERGIC v-SNARES Reactome DB_ID: 10711512 sec22 SEC22B Q9Y7L0 Reactome DB_ID: 10711508 2 EQUAL 215 EQUAL Reactome Database ID Release 77 10711508 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711508 Reactome R-SPO-5688565 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688565.1 ykt6 PalmC-YKT6 O60073 Reactome DB_ID: 10711510 1 EQUAL 196 EQUAL Reactome Database ID Release 77 10711510 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711510 Reactome R-SPO-5688557 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688557.1 Reactome Database ID Release 77 10711512 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711512 Reactome R-SPO-5694328 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694328.1 1 SEC23:SEC24 Reactome DB_ID: 10711498 sec231 SEC23A O74873 Reactome DB_ID: 10711496 1 EQUAL 765 EQUAL Reactome Database ID Release 77 10711496 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711496 Reactome R-SPO-204024 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204024.1 1 Converted from EntitySet in Reactome SEC24 Reactome DB_ID: 10711494 sec24 SEC24A Q9UUI5 Reactome DB_ID: 10711486 1 EQUAL 1093 EQUAL Reactome Database ID Release 77 10711486 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711486 Reactome R-SPO-204022 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204022.1 SEC24C Q9USS7 Reactome DB_ID: 10711490 1 EQUAL 1094 EQUAL Reactome Database ID Release 77 10711490 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711490 Reactome R-SPO-204026 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204026.1 SEC24D Q9USS7 Reactome DB_ID: 10711492 1 EQUAL 1032 EQUAL Reactome Database ID Release 77 10711492 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711492 Reactome R-SPO-204020 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204020.1 Reactome Database ID Release 77 10711494 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711494 Reactome R-SPO-204017 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204017.1 1 Reactome Database ID Release 77 10711498 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711498 Reactome R-SPO-204023 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204023.1 1 SEC13:SEC31A:SEC23IP Reactome DB_ID: 10711506 sec13 SEC13 O94319 Reactome DB_ID: 10711502 2 EQUAL 322 EQUAL Reactome Database ID Release 77 10711502 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711502 Reactome R-SPO-204012 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204012.1 2 P87109 SEC23IP Reactome DB_ID: 10711504 COPII-coated ER to Golgi transport vesicle GENE ONTOLOGY GO:0030134 1 EQUAL 1000 EQUAL Reactome Database ID Release 77 10711504 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711504 Reactome R-SPO-5688153 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688153.1 1 sec31 SEC31A O13637 Reactome DB_ID: 10711500 1 EQUAL 1220 EQUAL Reactome Database ID Release 77 10711500 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711500 Reactome R-SPO-204010 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204010.1 2 Reactome Database ID Release 77 10711506 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711506 Reactome R-SPO-5694320 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694320.1 1 SEC23A:SEC24C,D:GOSR2,STX5 Reactome DB_ID: 10711520 1 Converted from EntitySet in Reactome GOSR2,STX5 Reactome DB_ID: 10711518 bos1 GOSR2 Q9P7G5 Reactome DB_ID: 10711514 1 EQUAL 212 EQUAL Reactome Database ID Release 77 10711514 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711514 Reactome R-SPO-5689800 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5689800.1 sed5 STX5 O13644 Reactome DB_ID: 10711516 1 EQUAL 355 EQUAL Reactome Database ID Release 77 10711516 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711516 Reactome R-SPO-5689838 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5689838.1 Reactome Database ID Release 77 10711518 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711518 Reactome R-SPO-5694236 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694236.1 1 1 Reactome Database ID Release 77 10711520 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711520 Reactome R-SPO-5694270 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694270.1 1 Reactome Database ID Release 77 10711522 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10711522 Reactome R-SPO-5694329 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694329.1 COPII货物:受体:SEC23: SEC24: SEC13: SEC31: SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP Reactome DB_ID: 10723878 1 1 1 Reactome Database ID Release 77 10723878 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723878 Reactome R-SPO-5694334 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694334.1 Reactome Database ID Release 77 10723964 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723964 Reactome R-SPO-5694439 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694439.1 TRAPPC is a multi-subunit tethering complex that facilitates ER-to-Golgi traffic (reviewed in Barrowman et al, 2010; Brunet and Sacher, 2014). TRAPPC is a guanine-nucleotide exchange factor for RAB1 and is recruited to ER-derived vesicles by virtue of an interaction between the TRAPPC component TRAPPC3 and the coat protein SEC23 (Cai et al, 2007; Lord et al, 2011). 20966969 Pubmed 2010 TRAPP complexes in membrane traffic: convergence through a common Rab Barrowman, Jemima Bhandari, Deepali Reinisch, Karin Ferro-Novick, Susan Nat. Rev. Mol. Cell Biol. 11:759-63 21532587 Pubmed 2011 Sequential interactions with Sec23 control the direction of vesicle traffic Lord, Christopher Bhandari, Deepali Menon, Shekar Ghassemian, Majid Nycz, Deborah Hay, Jesse Ghosh, Pradipta Ferro-Novick, Susan Nature 473:181-6 17287728 Pubmed 2007 TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 Cai, Huaqing Yu, Sidney Menon, Shekar Cai, Yiying Lazarova, Darina Fu, Chunmei Reinisch, Karin Hay, Jesse C Ferro-Novick, Susan Nature 445:941-4 24917561 Pubmed 2014 In sickness and in health: the role of TRAPP and associated proteins in disease Brunet, Stephanie Sacher, Michael Traffic 15:803-18 LEFT-TO-RIGHT Nucleotide exchange on RAB1 This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp COPII货物:受体:SEC23: SEC24: SEC13: SEC31: SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP Reactome DB_ID: 10723882 1 RAB1:GTP Reactome DB_ID: 10723880 1 1 Reactome Database ID Release 77 10723880 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723880 Reactome R-SPO-5694299 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694299.1 1 1 Reactome Database ID Release 77 10723882 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723882 Reactome R-SPO-5694330 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694330.1 ACTIVATION activeUnit: #Complex13 Reactome Database ID Release 77 10723883 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723883 Reactome Database ID Release 77 10723885 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723885 Reactome R-SPO-5694409 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694409.1 The TRAPPC complex acts as a guanine-nucleotide exchange factor for RAB1, activating it (Yamasaki et al, 2009; reviewed in Brunet and Sacher, 2014). 19656848 Pubmed 2009 mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles Yamasaki, Akinori Menon, Shekar Yu, Sidney Barrowman, Jemima Meerloo, Timo Oorschot, Viola Klumperman, Judith Satoh, Ayano Ferro-Novick, Susan Mol. Biol. Cell 20:4205-15 LEFT-TO-RIGHT 2.7.11 CSNK1D phosphorylates SEC23 This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 77 113592 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 3 COPII货物:受体:SEC23: SEC24: SEC13: SEC31: SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 Reactome DB_ID: 10723979 endoplasmic reticulum-Golgi intermediate compartment membrane GENE ONTOLOGY GO:0033116 USO1 homodimer Reactome DB_ID: 10723977 uso1 USO1 Q09857 Reactome DB_ID: 10723975 UniProt:Q09857 uso1 UniProt Q09857 1 EQUAL 962 EQUAL Reactome Database ID Release 77 10723975 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723975 Reactome R-SPO-2311338 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-2311338.1 2 Reactome Database ID Release 77 10723977 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723977 Reactome R-SPO-2311342 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-2311342.1 1 1 GOLGA2:GORASP1 Reactome DB_ID: 10723970 Ghost homologue of GOLGA2 Reactome DB_ID: 10723966 Reactome Database ID Release 77 10723966 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723966 Reactome R-SPO-2167933 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-2167933.1 1 Q10149 GORASP1 Reactome DB_ID: 10723968 UniProt:Q10149 UniProt Q10149 2 EQUAL 440 EQUAL Reactome Database ID Release 77 10723968 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723968 Reactome R-SPO-162984 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-162984.1 1 Reactome Database ID Release 77 10723970 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723970 Reactome R-SPO-5694327 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694327.1 1 Reactome Database ID Release 77 10723979 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723979 Reactome R-SPO-5694332 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694332.1 COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer Reactome DB_ID: 10723985 1 1 1 1 Reactome Database ID Release 77 10723985 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723985 Reactome R-SPO-5694326 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694326.1 RAB1:GTP Reactome DB_ID: 10723991 ypt1 RAB1B P11620 Reactome DB_ID: 10723987 1 EQUAL 201 EQUAL Reactome Database ID Release 77 10723987 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723987 Reactome R-SPO-6807768 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807768.1 1 1 Reactome Database ID Release 77 10723991 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723991 Reactome R-SPO-6807799 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807799.1 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 77 29370 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 3 O74873 phospho-sec231 p-S742,T747 SEC23A Reactome DB_ID: 10723983 742 EQUAL O-phospho-L-serine MOD MOD:00046 747 EQUAL O-phospho-L-threonine MOD MOD:00047 1 EQUAL 765 EQUAL Reactome Database ID Release 77 10723983 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723983 Reactome R-SPO-5685740 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5685740.1 Converted from EntitySet in Reactome p-SEC24 Reactome DB_ID: 10723915 Q9UUI5 phospho-sec24 p-SEC24A Reactome DB_ID: 10723906 phosphorylated residue MOD MOD:00696 1 EQUAL 1093 EQUAL Reactome Database ID Release 77 10723906 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723906 Reactome R-SPO-5685743 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5685743.1 Q9USS7 phospho-p-SEC24C Reactome DB_ID: 10723911 1 EQUAL 1094 EQUAL Reactome Database ID Release 77 10723911 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723911 Reactome R-SPO-5694551 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694551.1 Q9USS7 phospho-p-SEC24D Reactome DB_ID: 10723913 1 EQUAL 1032 EQUAL Reactome Database ID Release 77 10723913 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723913 Reactome R-SPO-5694554 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694554.1 Reactome Database ID Release 77 10723915 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723915 Reactome R-SPO-5694187 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694187.1 ACTIVATION hhp1 CSNK1D P40235 Reactome DB_ID: 10723996 UniProt:P40235 hhp1 UniProt P40235 1 EQUAL 415 EQUAL Reactome Database ID Release 77 10723996 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723996 Reactome R-SPO-5685717 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5685717.1 GENE ONTOLOGY GO:0004674 Reactome Database ID Release 77 10723997 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723997 Reactome Database ID Release 77 10723999 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723999 Reactome R-SPO-5694441 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694441.1 Coat release at the ERGIC membrane may be stimulated by CSNK1D-dependent phosphorylation of SEC23 and SEC24 (Lord et al, 2011). LEFT-TO-RIGHT NSF and SNAPs bind cis-SNARE complex This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp NSF hexamer Reactome DB_ID: 10723922 NSF sec18 Q9P7Q4 Reactome DB_ID: 10723920 UniProt:Q9P7Q4 sec18 UniProt Q9P7Q4 1 EQUAL 744 EQUAL Reactome Database ID Release 77 10723920 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723920 Reactome R-SPO-264471 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-264471.1 6 Reactome Database ID Release 77 10723922 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723922 Reactome R-SPO-2193131 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-2193131.1 NAPA sec17 Q9P4X4 Reactome DB_ID: 10713237 UniProt:Q9P4X4 sec17 UniProt Q9P4X4 1 EQUAL 295 EQUAL Reactome Database ID Release 77 10713237 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10713237 Reactome R-SPO-264469 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-264469.1 3 cis-SNARE Reactome DB_ID: 10723955 BET1:GOSR2:STX5:SCFD1 Reactome DB_ID: 10723947 bos1 GOSR2 Q9P7G5 Reactome DB_ID: 10723931 1 EQUAL 212 EQUAL Reactome Database ID Release 77 10723931 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723931 Reactome R-SPO-535472 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-535472.1 1 sly1 SCFD1 O74534 Reactome DB_ID: 10723936 UniProt:O74534 sly1 UniProt O74534 1 EQUAL 642 EQUAL Reactome Database ID Release 77 10723936 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723936 Reactome R-SPO-5688147 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688147.1 1 Converted from EntitySet in Reactome STX5,17 Reactome DB_ID: 10723945 sed5 STX5 O13644 Reactome DB_ID: 10723938 1 EQUAL 355 EQUAL Reactome Database ID Release 77 10723938 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723938 Reactome R-SPO-5688157 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688157.1 pep12 STX17 O94651 Reactome DB_ID: 10723943 UniProt:O94651 pep12 UniProt O94651 2 EQUAL 302 EQUAL Reactome Database ID Release 77 10723943 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723943 Reactome R-SPO-6807769 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807769.1 Reactome Database ID Release 77 10723945 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723945 Reactome R-SPO-6807784 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807784.1 1 bet1 BET1 O13932 Reactome DB_ID: 10723929 UniProt:O13932 bet1 UniProt O13932 1 EQUAL 118 EQUAL Reactome Database ID Release 77 10723929 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723929 Reactome R-SPO-5688142 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688142.1 1 Reactome Database ID Release 77 10723947 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723947 Reactome R-SPO-5694305 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694305.1 1 Converted from EntitySet in Reactome ER-to-ERGIC v-SNARES Reactome DB_ID: 10723953 sec22 SEC22B Q9Y7L0 Reactome DB_ID: 10723949 2 EQUAL 215 EQUAL Reactome Database ID Release 77 10723949 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723949 Reactome R-SPO-5688566 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688566.1 ykt6 PalmC-YKT6 O60073 Reactome DB_ID: 10723951 1 EQUAL 196 EQUAL Reactome Database ID Release 77 10723951 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723951 Reactome R-SPO-5688558 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688558.1 Reactome Database ID Release 77 10723953 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723953 Reactome R-SPO-5694306 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694306.1 1 Reactome Database ID Release 77 10723955 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723955 Reactome R-SPO-5694303 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694303.1 cis-SNARE:NSF hexamer:3xSNAP Reactome DB_ID: 10723957 1 3 1 Reactome Database ID Release 77 10723957 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723957 Reactome R-SPO-5694312 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694312.1 Reactome Database ID Release 77 10723959 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723959 Reactome R-SPO-5694423 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694423.1 After membrane fusion, the cis-SNARE complex is dissociated in an ATP-dependent fashion by the AAA protein NSF in conjunction with SNAP proteins (Mayer et al, 1996; Sollner et al, 1993; reviewed in Jahn and Scheller, 2006; Sudhof and Rothman, 2009). 8620540 Pubmed 1996 Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles Mayer, Andreas Wickner, William Haas, Albert Cell 85:83-94 19164740 Pubmed 2009 Membrane fusion: grappling with SNARE and SM proteins Südhof, Thomas C Rothman, James E Science 323:474-7 8221884 Pubmed 1993 A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion Sollner, Thomas Bennett, Mark K Whiteheart, Sidney W Scheller, Richard H Rothman, James E Cell 75:409-18 16912714 Pubmed 2006 SNAREs--engines for membrane fusion Jahn, Reinhard Scheller, Richard H Nat. Rev. Mol. Cell Biol. 7:631-43 LEFT-TO-RIGHT 3.6.1.3 NSF ATPase activity dissociates cis-SNARE This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp 3 ACTIVATION activeUnit: #Complex27 GENE ONTOLOGY 去:0016887 Reactome Database ID Release 77 10723960 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723960 Reactome Database ID Release 77 10723962 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10723962 Reactome R-SPO-5694425 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694425.1 NSF-dependent hydrolysis of ATP is required to disassociate the cis-SNARE complex, releasing the SNAREs for further rounds of membrane fusion (Mayer et al, 1996; Muller et al, 1999; Muller et al, 2002; Otto et al, 1997; Whiteheart et al, 2004; Yu et al, 1999; Zhao et al, 2012; Shah et al, 2015; reviewed in Sudhof and Rothman, 2009). 10445031 Pubmed 1999 NSF N-terminal domain crystal structure: models of NSF function Yu, Richard C Jahn, Reinhard Brunger, Axel T Mol. Cell 4:97-107 25492864 Pubmed 2015 Three ?SNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF) Shah, Niket Colbert, Karen N Enos, Michael D Herschlag, Daniel Weis, William I J. Biol. Chem. 290:2175-88 15037235 Pubmed 2004 Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor Whiteheart, Sidney W Matveeva, Elena A J. Struct. Biol. 146:32-43 10559959 Pubmed 1999 An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion Müller, Joyce M Rabouille C Newman, Richard Shorter, James Freemont, Paul Schiavo, Giampietro Warren, Graham Shima, David T Nat. Cell Biol. 1:335-40 9177194 Pubmed 1997 Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles Otto, Henning Hanson, Phyllis I Jahn, Reinhard Proc. Natl. Acad. Sci. U.S.A. 94:6197-201 12070132 Pubmed 2002 Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion Muller, Joyce M M Shorter, James Newman, Richard Deinhardt, Katrin Sagiv, Yuval Elazar, Zvulun Warren, Graham Shima, David T J. Cell Biol. 157:1161-73 21689688 Pubmed 2012 Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF) Zhao, Chunxia Smith, Everett C Whiteheart, Sidney W Biochim. Biophys. Acta 1823:159-71 LEFT-TO-RIGHT TBC1D20 binds RAB1:GTP This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp gyp10 TBC1D20 O94661 Reactome DB_ID: 10727682 UniProt:O94661 gyp10 UniProt O94661 1 EQUAL 403 EQUAL Reactome Database ID Release 77 10727682 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727682 Reactome R-SPO-6814813 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6814813.1 RAB1:GTP:TBC1D20 Reactome DB_ID: 10727684 1 1 Reactome Database ID Release 77 10727684 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727684 Reactome R-SPO-6814832 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6814832.1 Reactome Database ID Release 77 10727686 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727686 Reactome R-SPO-6814831 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6814831.1 TBC1D20 was identified as a GTPase activating protein for RAB1 that stimulates basal GTP hydrolysis by more than 5 orders of magnitude (Haas et al, 2007; Fuchs et al, 2007). 17684057 Pubmed 2007 Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells Haas, Alexander K Yoshimura, Shin-ichiro Stephens, David J Preisinger, Christian Fuchs, Evelyn Barr, Francis A J. Cell. Sci. 120:2997-3010 17562788 Pubmed 2007 Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways Fuchs, Evelyn Haas, Alexander K Spooner, Robert A Yoshimura, Shin-ichiro Lord, J Michael Barr, Francis A J. Cell Biol. 177:1133-43 LEFT-TO-RIGHT 3.6.5.4 3.6.5.3 3.6.5.2 3.6.5.1 TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp ACTIVATION Reactome Database ID Release 77 10727687 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727687 Reactome Database ID Release 77 10727689 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727689 Reactome R-SPO-6814833 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6814833.1 TBC1D20 was identified as a RAB1-specific GTPase activating protein (GAP) that stimulates RAB1-mediated GTP hydrolysis and plays roles in ER-to-Golgi trafficking. TBC1D20 is the only GAP that has been identified to block delivery of secretory cargo from the ER to the cell surface (Haas et al, 2007). Reactome Database ID Release 77 10732856 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10732856 Reactome R-SPO-204005 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-204005.1 GENE ONTOLOGY GO:0048208 gene ontology term for cellular process MI MI:0359 COPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles were originally discovered in the yeast Saccharomyces cerevisiae using genetic approaches coupled with a cell-free assay. The mammalian counterpart of this pathway is represented here. Newly synthesized proteins destined for secretion are sorted into COPII-coated vesicles at specialized regions of the ER. These vesicles leave the ER, become uncoated and subsequently fuse with the ERGIC membrane. 11252894 Pubmed 2000 Three ways to make a vesicle Kirchhausen, Tomas Nat Rev Mol Cell Biol 1:187-98 COPI-mediated anterograde transport This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp LEFT-TO-RIGHT RAB1:GTP recruits GBF1 to the ERGIC This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Converted from EntitySet in Reactome Homologues of GBF1 Reactome DB_ID: 10726833 GBF1 O13690 Reactome DB_ID: 10726825 UniProt:O13690 UniProt O13690 1 EQUAL 1859 EQUAL Reactome Database ID Release 77 10726825 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726825 Reactome R-SPO-6807751 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807751.1 GBF1 sec73 O13817 Reactome DB_ID: 10726827 UniProt:O13817 sec73 UniProt O13817 1 EQUAL 1859 EQUAL Reactome Database ID Release 77 10726827 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726827 Reactome R-SPO-6807751-2 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807751-2.1 GBF1 sec74 Q10491 Reactome DB_ID: 10726829 UniProt:Q10491 sec74 UniProt Q10491 1 EQUAL 1859 EQUAL Reactome Database ID Release 77 10726829 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726829 Reactome R-SPO-6807751-3 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807751-3.1 GBF1 Q9P7R8 Reactome DB_ID: 10726831 UniProt:Q9P7R8 UniProt Q9P7R8 1 EQUAL 1859 EQUAL Reactome Database ID Release 77 10726831 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726831 Reactome R-SPO-6807751-4 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807751-4.1 Reactome Database ID Release 77 10726833 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726833 Reactome R-SPO-6807751-5 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807751-5.1 USO1 homodimer Reactome DB_ID: 10726837 uso1 USO1 Q09857 Reactome DB_ID: 10726835 1 EQUAL 962 EQUAL Reactome Database ID Release 77 10726835 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726835 Reactome R-SPO-5685737 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5685737.1 2 Reactome Database ID Release 77 10726837 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726837 Reactome R-SPO-5694302 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5694302.1 RAB1:GTP:GBF1:USO1 Reactome DB_ID: 10726839 1 1 1 Reactome Database ID Release 77 10726839 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726839 Reactome R-SPO-6807800 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807800.1 Reactome Database ID Release 77 10726841 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726841 Reactome R-SPO-6807864 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807864.1 In its GTP-bound active state, RAB1 recruits the ARF GEF GBF1 to the ERGIC (Monetta et al, 2007). GBF1 is the only ARF activator required for the formation of COPI coats, and it therefore has roles in the anterograde ERGIC-to-cis-Golgi pathway as well as in COPI-mediated retrograde transport within the Golgi and back to the ERGIC and ER (Kawamoto et al, 2002; Szul et al, 2005; Zhao et al, 2006; Szul et al, 2007; reviewed in Szul and Sztul, 2011). GBF1 activates ARF4 which is concentrated at the ERGIC compartment, but also ARF1 and ARF5 which have more generalized localization within the secretory pathway (Volpicelli-Daley et al, 2005; Chun et al, 2008; reviewed in D'Souza-Schorey and Chavrier, 2006). GBF1 also interacts with the USO1 homodimer, a long coiled-coil tethering factor (Garcia-Mata and Sztul, 2003). 12047556 Pubmed 2002 GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat Kawamoto, Kazumasa Yoshida, Yusaku Tamaki, Hideaki Torii, Seiji Shinotsuka, Chisa Yamashina, Shohei Nakayama, Kazuhisa Traffic 3:483-95 17956946 Pubmed 2007 Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking Szul, Tomasz Grabski, Robert Lyons, Susan Morohashi, Yuichi Shestopal, Svetlana Lowe, M Sztul, Elizabeth J. Cell. Sci. 120:3929-40 15813748 Pubmed 2005 Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1 Szul, Tomasz Garcia-Mata, Rafael Brandon, Elizabeth Shestopal, Svetlana Alvarez, Cecilia Sztul, Elizabeth Traffic 6:374-85 17429068 Pubmed 2007 Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association Monetta, Pablo Slavin, Ileana Romero, Nahuel Alvarez, Cecilia Mol. Biol. Cell 18:2400-10 16926190 Pubmed 2006 GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic Zhao, Xinhua Claude, Alejandro Chun, Justin Shields, David J Presley, John F Melançon, Paul J. Cell. Sci. 119:3743-53 12634853 Pubmed 2003 The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor Garcia-Mata, Rafael Sztul, Elizabeth EMBO Rep. 4:320-5 18524849 Pubmed 2008 Characterization of class I and II ADP-ribosylation factors (Arfs) in live cells: GDP-bound class II Arfs associate with the ER-Golgi intermediate compartment independently of GBF1 Chun, Justin Shapovalova, Zoya Dejgaard, Selma Y Presley, John F Melançon, Paul Mol. Biol. Cell 19:3488-500 16030262 Pubmed 2005 Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic Volpicelli-Daley, Laura A Li, Yawei Zhang, Chun-Jiang Kahn, Richard A Mol. Biol. Cell 16:4495-508 16633337 Pubmed 2006 ARF proteins: roles in membrane traffic and beyond D'Souza-Schorey, Crislyn Chavrier, Philippe Nat. Rev. Mol. Cell Biol. 7:347-58 LEFT-TO-RIGHT GBF1 recruits ARF:GDP to the ERGIC This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp ARF4:GDP Reactome DB_ID: 10720245 arf1 ARF4 P36579 Reactome DB_ID: 10720241 UniProt:P36579 arf1 UniProt P36579 2 EQUAL N-myristoylglycine MOD MOD:00068 2 EQUAL 180 EQUAL Reactome Database ID Release 77 10720241 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10720241 Reactome R-SPO-5618178 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5618178.1 1 1 Reactome Database ID Release 77 10720245 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10720245 Reactome R-SPO-5623424 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5623424.1 RAB1:GTP:GBF1:USO1:ARF:GDP Reactome DB_ID: 10726845 1 1 Reactome Database ID Release 77 10726845 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726845 Reactome R-SPO-6807803 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807803.1 Reactome Database ID Release 77 10726847 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726847 Reactome R-SPO-6807866 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807866.1 GBF1 recruits inactive ARF:GDP complexes to the ERGIC (Monetta et al, 2007). There are 5 known ADP-ribosylation factor proteins (ARFs) in the human cell. Class I members ARF1 and ARF 3 are expressed at high levels and broadly distributed through the secretory system, while Class II members ARF4 and ARF5 are expressed at lower levels, with ARF4 showing the most specific localization to the ERGIC compartment. ARF6, the single Class III ARF, appears to function more specifically in endocytosis and actin dynamics (Chun et al, 2008; reviewed in D'Souza-Schorey and Chavrier, 2006; Szul and Sztul, 2011). There is conflicting evidence regarding what ARF(s) is required at the ERGIC membrane. GBF1 has been shown to activate ARF1, 4, and 5, but not ARF3, while single and pairwise knockdown of ARF1, 3, 4 and 5 suggests that although no single ARF is responsible for any given step in the secretory pathway, ARF1 and ARF3 contribute most specifically to the ERGIC-Golgi step (Manolea et al, 2010; Volpicelli-Daley et al, 2005). Recruitment of ARF at may also be facilitated by interaction with p24 family members (Gommel et al, 2001; reviewed in Schuiki and Volchuk, 2012). 20357002 Pubmed 2010 Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors Manolea, Florin Chun, Justin 陈,David W Clarke, Ian Summerfeldt, Nathan Dacks, Joel B Melançon, Paul Mol. Biol. Cell 21:1836-49 11726511 Pubmed 2001 Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23 Gommel, Daniel U Memon, Abdul R Heiss, Armin Lottspeich, Friedrich Pfannstiel, Johannes Lechner, Jens Reinhard, Constanze Helms, J Bernd Nickel, Walter Wieland, Felix T EMBO J. 20:6751-60 25436559 Pubmed 2012 Diverse roles for the p24 family of proteins in eukaryotic cells Schuiki, Irmgard Volchuk, Allen Biomol Concepts 3:561-70 LEFT-TO-RIGHT GBF1 stimulates ARF nucleotide exchange This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp RAB1:GTP:GBF1:USO1:ARF:GTP Reactome DB_ID: 10726849 1 ARF4:GTP Reactome DB_ID: 10720243 1 1 Reactome Database ID Release 77 10720243 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10720243 Reactome R-SPO-5623423 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5623423.1 1 Reactome Database ID Release 77 10726849 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726849 Reactome R-SPO-6807820 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807820.1 ACTIVATION activeUnit: #Protein72 Reactome Database ID Release 77 10726850 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726850 Reactome Database ID Release 77 10726852 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726852 Reactome R-SPO-6807868 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807868.1 GBF1 facilitates the exchange of GDP for GTP, activating ARF (Niu et al, 2005; Szul et al, 2005; Szul et al, 2007; Kawamoto et al, 2002; reviewed in Szul and Sztul, 2011). 15616190 Pubmed 2005 Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi Niu, Ting-Kuang Pfeifer, Andrea C Lippincott-Schwartz, Jennifer Jackson, Catherine L Mol. Biol. Cell 16:1213-22 LEFT-TO-RIGHT Active ARF recruits coatomer This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp coatomer Reactome DB_ID: 10726891 trimeric coatomer complex Reactome DB_ID: 10726889 COPE sec28 O74767 Reactome DB_ID: 10726887 UniProt:O74767 sec28 UniProt O74767 2 EQUAL 308 EQUAL Reactome Database ID Release 77 10726887 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726887 Reactome R-SPO-199969 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-199969.1 1 COPA Q96WV5 Reactome DB_ID: 10726877 UniProt:Q96WV5 UniProt Q96WV5 1 EQUAL 1224 EQUAL Reactome Database ID Release 77 10726877 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726877 Reactome R-SPO-199978 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-199978.1 1 sec27 COPB2 O42937 Reactome DB_ID: 10726882 UniProt:O42937 sec27 UniProt O42937 2 EQUAL 906 EQUAL Reactome Database ID Release 77 10726882 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726882 Reactome R-SPO-199972 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-199972.1 1 Reactome Database ID Release 77 10726889 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726889 Reactome R-SPO-6807807 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807807.1 1 tetrameric coatomer complex Reactome DB_ID: 10726872 sec21 COPG2 P87140 Reactome DB_ID: 10726857 UniProt:P87140 sec21 UniProt P87140 1 EQUAL 871 EQUAL Reactome Database ID Release 77 10726857 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726857 Reactome R-SPO-6807747 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807747.1 1 Ghost homologue of ARCN1 Reactome DB_ID: 10726868 Reactome Database ID Release 77 10726868 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726868 Reactome R-SPO-199980 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-199980.1 1 sec26 COPB1 Q9UUF7 Reactome DB_ID: 10726870 UniProt:Q9UUF7 sec26 UniProt Q9UUF7 1 EQUAL 953 EQUAL Reactome Database ID Release 77 10726870 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726870 Reactome R-SPO-199995 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-199995.1 1 ret3 COPZ2 O74891 Reactome DB_ID: 10726864 UniProt:O74891 ret3 UniProt O74891 1 EQUAL 210 EQUAL Reactome Database ID Release 77 10726864 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726864 Reactome R-SPO-6807748 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807748.1 1 Reactome Database ID Release 77 10726872 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726872 Reactome R-SPO-6807806 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807806.1 1 Reactome Database ID Release 77 10726891 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726891 Reactome R-SPO-6807805 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807805.1 RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer Reactome DB_ID: 10726893 1 1 Reactome Database ID Release 77 10726893 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726893 Reactome R-SPO-6807822 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807822.1 Reactome Database ID Release 77 10726895 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726895 Reactome R-SPO-6807872 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807872.1 Activation of ARF is tightly linked to the recruitment of the COPI coat (Donaldson et al, 1991; Serafini et al, 1991; Donaldson et el, 1992; Palmer et al, 1993; reveiwed in Szul and Sztul, 2011). Studies in yeast and in mammalian cells support a direct interaction between the GTPase and components of the COPI coat; recruitment may also be facilitated by interactions with p24 family members (Zhao et al, 1997; Zhao et al, 1999; Zhao et al, 2006; Eugster et al, 2000; Aguillera-Ramiero et al, 2008; Sun et al, 2007; Yu et al, 2012; Harter and Wieland, 1998; Bethune et al, 2006; reviewed in Popoff et al, 2011). The COPI coat consists of 7 subunits arranged in 2 subcomplexes. The inner coat is made up of a tetrameric complex consisting of the beta, gamma, zeta and delta COPI subunits, while the outer coat is a trimer consisting of the alpha, beta prime and epsilon subunits (Eugster et al, 2000; Waters et al, 1991). Both of the zeta and gamma subunits have 2 isoforms with different subcellular locations, suggesting that different COPI coats may mediate different steps of the secretory pathway (Moelleken et al, 2007). Unlike the case for COPII or clathrin coats, all components of the COPI coat are recruited simultaneously as a preformed heptameric complex (Hara-Kuge et al, 1994) 1680566 Pubmed 1991 ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein Serafini, Tito Orci, L Amherdt, Mylene Brunner, M Kahn, Richard A Rothman, James E Cell 67:239-53 8132710 Pubmed 1994 En bloc incorporation of coatomer subunits during the assembly of COP-coated vesicles Hara-Kuge, Sayuri Kuge, O Orci, L Amherdt, Mylene Ravazzola, Mariella Wieland, Felix T Rothman, James E J. Cell Biol. 124:883-92 9751720 Pubmed 1998 A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer Harter, Cordula Wieland, Felix T Proc. Natl. Acad. Sci. U.S.A. 95:11649-54 16940185 Pubmed 2006 Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins Béthune, Julien Kol, Matthijs Hoffmann, Julia Reckmann, Inge Brugger, Britta Wieland, Felix Mol. Cell. Biol. 26:8011-21 22304919 Pubmed 2012 A structure-based mechanism for Arf1-dependent recruitment of coatomer to membranes Yu, Xinchao Breitman, Marianna Goldberg, Jonathan Cell 148:530-42 1898986 Pubmed 1991 'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles Waters, M Gerard Serafini, Tito Rothman, James E Nature 349:248-51 21844168 Pubmed 2011 COPI budding within the Golgi stack Popoff, Vincent Adolf, Frank Brugger, Britta Wieland, Felix Cold Spring Harb Perspect Biol 3:a005231 17451557 Pubmed 2007 Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP Sun, Zhe Anderl, Frank Fröhlich, Kathrin Zhao, Liyun Hanke, Stefan Brugger, Britta Wieland, Felix Béthune, Julien Traffic 8:582-93 10318838 Pubmed 1999 GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23 Zhao, Liyun Helms, J Bernd Brunner, Josef Wieland, Felix T J. Biol. Chem. 274:14198-203 8505331 Pubmed 1993 Binding of coatomer to Golgi membranes requires ADP-ribosylation factor Palmer, David J Helms, J Bernd Beckers, Con J Orci, L Rothman, James E J. Biol. Chem. 268:12083-9 10921873 Pubmed 2000 COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP Eugster, Anne Frigerio, Gabriella Dale, Martin Duden, Rainer EMBO J. 19:3905-17 1957170 Pubmed 1991 Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein Donaldson, Julie G Kahn, Richard A Lippincott-Schwartz, Jennifer Klausner, Richard D Science 254:1197-9 17360540 Pubmed 2007 Differential localization of coatomer complex isoforms within the Golgi apparatus Moelleken, Jörg Malsam, Jörg Betts, Matthew J Movafeghi, Ali Reckmann, Ingeborg Meissner, Ingrid Hellwig, Andrea Russell, Robert B Sollner, Thomas Brugger, Britta Wieland, Felix T Proc. Natl. Acad. Sci. U.S.A. 104:4425-30 1631136 Pubmed 1992 ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes Donaldson, Julie G Cassel, Dan Kahn, Richard A Klausner, Richard D Proc. Natl. Acad. Sci. U.S.A. 89:6408-12 18283113 Pubmed 2008 The yeast p24 complex is required for the formation of COPI retrograde transport vesicles from the Golgi apparatus Aguilera-Romero, Auxiliadora Kaminska, Joanna Spang, Anne Riezman, H Muñiz, Manuel J. Cell Biol. 180:713-20 9114004 Pubmed 1997 Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta Zhao, Liyun Helms, J Bernd Brugger, Britta Harter, Cordula Martoglio, Bruno Graf, Roland Brunner, Josef Wieland, Felix T Proc. Natl. Acad. Sci. U.S.A. 94:4418-23 LEFT-TO-RIGHT 3.6.5.4 3.6.5.3 3.6.5.2 3.6.5.1 ARFGAPs stimulate ARF GTPase activity This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin Reactome DB_ID: 10726965 Spectrin tetramer Reactome DB_ID: 10726961 SPTA:SPTB Reactome DB_ID: 10726959 ain1 SPTB O13728 Reactome DB_ID: 10726951 UniProt: O13728 ain1 UniProt O13728 2 EQUAL 2137 EQUAL Reactome Database ID Release 77 10726951 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726951 Reactome R-SPO-391565 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-391565.1 1 ain1 SPTA1 O13728 Reactome DB_ID: 10726949 1 EQUAL 2419 EQUAL Reactome Database ID Release 77 10726949 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726949 Reactome R-SPO-391563 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-391563.1 1 Reactome Database ID Release 77 10726959 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726959 Reactome R-SPO-391839 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-391839.1 2 Reactome Database ID Release 77 10726961 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726961 Reactome R-SPO-420053 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-420053.1 1 Ghost homologue of Ankyrin Reactome DB_ID: 10726963 Reactome Database ID Release 77 10726963 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726963 Reactome R-SPO-427190 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-427190.1 1 1 Converted from EntitySet in Reactome p24 dimers Reactome DB_ID: 10726938 TMED10 dimer Reactome DB_ID: 10726906 erv25 TMED10 O13946 Reactome DB_ID: 10726904 UniProt:O13946 erv25 UniProt O13946 32 EQUAL 219 EQUAL Reactome Database ID Release 77 10726904 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726904 Reactome R-SPO-5689845 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5689845.1 2 Reactome Database ID Release 77 10726906 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726906 Reactome R-SPO-6807813 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807813.1 TMED2 dimer Reactome DB_ID: 10726910 emp24 TMED2 Q9P7I9 Reactome DB_ID: 10726908 UniProt:Q9P7I9 emp24 UniProt Q9P7I9 21 EQUAL 201 EQUAL Reactome Database ID Release 77 10726908 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726908 Reactome R-SPO-1911531 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1911531.1 2 Reactome Database ID Release 77 10726910 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726910 Reactome R-SPO-6807814 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807814.1 TMED3 dimer Reactome DB_ID: 10726921 Converted from EntitySet in Reactome 同系物的TMED3 Reactome DB_ID: 10726919 TMED3 O13770 Reactome DB_ID: 10726915 UniProt:O13770 UniProt O13770 24 EQUAL 217 EQUAL Reactome Database ID Release 77 10726915 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726915 Reactome R-SPO-6807773 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807773.1 emp24 TMED3 Q9P7I9 Reactome DB_ID: 10726917 24 EQUAL 217 EQUAL Reactome Database ID Release 77 10726917 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726917 Reactome R-SPO-6807773-2 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807773-2.1 Reactome Database ID Release 77 10726919 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726919 Reactome R-SPO-6807773-3 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807773-3.1 2 Reactome Database ID Release 77 10726921 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726921 Reactome R-SPO-6807815 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807815.1 TMED7 dimer Reactome DB_ID: 10726929 Converted from EntitySet in Reactome 同系物的TMED7 Reactome DB_ID: 10726927 TMED7 O13770 Reactome DB_ID: 10726923 35 EQUAL 224 EQUAL Reactome Database ID Release 77 10726923 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726923 Reactome R-SPO-6807776 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807776.1 emp24 TMED7 Q9P7I9 Reactome DB_ID: 10726925 35 EQUAL 224 EQUAL Reactome Database ID Release 77 10726925 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726925 Reactome R-SPO-6807776-2 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807776-2.1 Reactome Database ID Release 77 10726927 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726927 Reactome R-SPO-6807776-3 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807776-3.1 2 Reactome Database ID Release 77 10726929 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726929 Reactome R-SPO-6807817 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807817.1 TMED9 dimer Reactome DB_ID: 10726936 TMED9 O14324 Reactome DB_ID: 10726934 UniProt:O14324 UniProt O14324 38 EQUAL 235 EQUAL Reactome Database ID Release 77 10726934 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726934 Reactome R-SPO-6807777 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807777.1 2 Reactome Database ID Release 77 10726936 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726936 Reactome R-SPO-6807819 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807819.1 Reactome Database ID Release 77 10726938 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726938 Reactome R-SPO-6807812 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807812.1 1 1 glo3 ARFGAP2 Q10367 Reactome DB_ID: 10726900 UniProt:Q10367 glo3 UniProt Q10367 2 EQUAL 521 EQUAL Reactome Database ID Release 77 10726900 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726900 Reactome R-SPO-6807738 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807738.1 1 Converted from EntitySet in Reactome ERGIC-to-cis-Golgi货物 Reactome DB_ID: 10726947 erd2 KDELR1 O94270 Reactome DB_ID: 10726943 UniProt:O94270 erd2 UniProt O94270 1 EQUAL 212 EQUAL Reactome Database ID Release 77 10726943 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726943 Reactome R-SPO-6807760 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807760.1 Reactome Database ID Release 77 10726947 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726947 Reactome R-SPO-6807816 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807816.1 1 Reactome Database ID Release 77 10726965 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726965 Reactome R-SPO-6807825 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807825.1 RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin Reactome DB_ID: 10727045 transport vesicle GENE ONTOLOGY GO:0030133 1 1 Converted from EntitySet in Reactome p24 dimers Reactome DB_ID: 10727043 TMED10 dimer Reactome DB_ID: 10727017 erv25 TMED10 O13946 Reactome DB_ID: 10727015 32 EQUAL 219 EQUAL Reactome Database ID Release 77 10727015 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727015 Reactome R-SPO-6808802 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808802.1 2 Reactome Database ID Release 77 10727017 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727017 Reactome R-SPO-6808879 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808879.1 TMED2 dimer Reactome DB_ID: 10727021 emp24 TMED2 Q9P7I9 Reactome DB_ID: 10727019 21 EQUAL 201 EQUAL Reactome Database ID Release 77 10727019 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727019 Reactome R-SPO-6808806 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808806.1 2 Reactome Database ID Release 77 10727021 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727021 Reactome R-SPO-6808881 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808881.1 TMED3 dimer Reactome DB_ID: 10727029 Converted from EntitySet in Reactome 同系物的TMED3 Reactome DB_ID: 10727027 TMED3 O13770 Reactome DB_ID: 10727023 24 EQUAL 217 EQUAL Reactome Database ID Release 77 10727023 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727023 Reactome R-SPO-6808874 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808874.1 emp24 TMED3 Q9P7I9 Reactome DB_ID: 10727025 24 EQUAL 217 EQUAL Reactome Database ID Release 77 10727025 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727025 Reactome R-SPO-6808874-2 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808874-2.1 Reactome Database ID Release 77 10727027 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727027 Reactome R-SPO-6808874-3 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808874-3.1 2 Reactome Database ID Release 77 10727029 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727029 Reactome R-SPO-6808884 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808884.1 TMED7 dimer Reactome DB_ID: 10727037 Converted from EntitySet in Reactome 同系物的TMED7 Reactome DB_ID: 10727035 TMED7 O13770 Reactome DB_ID: 10727031 35 EQUAL 224 EQUAL Reactome Database ID Release 77 10727031 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727031 Reactome R-SPO-6808875 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808875.1 emp24 TMED7 Q9P7I9 Reactome DB_ID: 10727033 35 EQUAL 224 EQUAL Reactome Database ID Release 77 10727033 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727033 Reactome R-SPO-6808875-2 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808875-2.1 Reactome Database ID Release 77 10727035 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727035 Reactome R-SPO-6808875-3 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808875-3.1 2 Reactome Database ID Release 77 10727037 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727037 Reactome R-SPO-6808886 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808886.1 TMED9 dimer Reactome DB_ID: 10727041 TMED9 O14324 Reactome DB_ID: 10727039 38 EQUAL 235 EQUAL Reactome Database ID Release 77 10727039 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727039 Reactome R-SPO-6808878 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808878.1 2 Reactome Database ID Release 77 10727041 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727041 Reactome R-SPO-6808887 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808887.1 Reactome Database ID Release 77 10727043 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727043 Reactome R-SPO-6808889 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808889.1 1 Converted from EntitySet in Reactome ERGIC-to-cis-Golgi货物 Reactome DB_ID: 10726973 bet1 BET1 O13932 Reactome DB_ID: 10726967 1 EQUAL 118 EQUAL Reactome Database ID Release 77 10726967 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726967 Reactome R-SPO-6808719 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808719.1 erd2 KDELR1 O94270 Reactome DB_ID: 10726969 1 EQUAL 212 EQUAL Reactome Database ID Release 77 10726969 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726969 Reactome R-SPO-6808782 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808782.1 Reactome Database ID Release 77 10726973 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726973 Reactome R-SPO-6808905 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808905.1 1 ykt6 PalmC-YKT6 O60073 Reactome DB_ID: 10726975 1 EQUAL 196 EQUAL Reactome Database ID Release 77 10726975 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726975 Reactome R-SPO-6808794 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808794.1 1 RAB1:GTP:USO1:coatomer Reactome DB_ID: 10727013 RAB1:GTP:USO1 Reactome DB_ID: 10726987 USO1 homodimer Reactome DB_ID: 10726985 uso1 USO1 Q09857 Reactome DB_ID: 10726983 1 EQUAL 962 EQUAL Reactome Database ID Release 77 10726983 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726983 Reactome R-SPO-6808817 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808817.1 2 Reactome Database ID Release 77 10726985 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726985 Reactome R-SPO-6808833 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808833.1 1 RAB1:GTP Reactome DB_ID: 10726981 ypt1 RAB1B P11620 Reactome DB_ID: 10726977 1 EQUAL 201 EQUAL Reactome Database ID Release 77 10726977 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726977 Reactome R-SPO-6808799 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808799.1 1 1 Reactome Database ID Release 77 10726981 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726981 Reactome R-SPO-6808826 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808826.1 1 Reactome Database ID Release 77 10726987 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726987 Reactome R-SPO-6808832 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808832.1 1 coatomer Reactome DB_ID: 10727011 tetrameric coatomer complex Reactome DB_ID: 10727001 Ghost homologue of ARCN1 Reactome DB_ID: 10726997 Reactome Database ID Release 77 10726997 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726997 Reactome R-SPO-6808717 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808717.1 1 sec26 COPB1 Q9UUF7 Reactome DB_ID: 10726999 1 EQUAL 953 EQUAL Reactome Database ID Release 77 10726999 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726999 Reactome R-SPO-6808736 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808736.1 1 sec21 COPG1 P87140 Reactome DB_ID: 10726989 1 EQUAL 874 EQUAL Reactome Database ID Release 77 10726989 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726989 Reactome R-SPO-6808749 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808749.1 1 ret3 COPZ1 O74891 Reactome DB_ID: 10726993 1 EQUAL 177 EQUAL Reactome Database ID Release 77 10726993 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10726993 Reactome R-SPO-6808756 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808756.1 1 Reactome Database ID Release 77 10727001 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727001 Reactome R-SPO-6808857 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808857.1 1 trimeric coatomer complex Reactome DB_ID: 10727009 COPA Q96WV5 Reactome DB_ID: 10727003 1 EQUAL 1224 EQUAL Reactome Database ID Release 77 10727003 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727003 Reactome R-SPO-6808732 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808732.1 1 sec27 COPB2 O42937 Reactome DB_ID: 10727005 2 EQUAL 906 EQUAL Reactome Database ID Release 77 10727005 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727005 Reactome R-SPO-6808741 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808741.1 1 COPE sec28 O74767 Reactome DB_ID: 10727007 2 EQUAL 308 EQUAL Reactome Database ID Release 77 10727007 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727007 Reactome R-SPO-6808745 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808745.1 1 Reactome Database ID Release 77 10727009 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727009 Reactome R-SPO-6808859 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808859.1 1 Reactome Database ID Release 77 10727011 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727011 Reactome R-SPO-6808858 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808858.1 1 Reactome Database ID Release 77 10727013 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727013 Reactome R-SPO-6808866 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808866.1 1 Reactome Database ID Release 77 10727045 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727045 Reactome R-SPO-6808903 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808903.1 ACTIVATION activeUnit: #Protein78 Reactome Database ID Release 77 10727046 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727046 Reactome Database ID Release 77 10727048 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727048 Reactome R-SPO-6807877 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807877.1 The ARFGAP proteins stimulates ARF GTPase activity, promoting the release of the nascent COPI vesicle from the membrane and release of ARF:ADP (Tanigawa et al, 1993; reviewed in Beck et al, 2009; East and Kahn, 2011). Although this reaction shows their dissociation, it is not clear whether ARFGAPs persist on the COPI vesicle after GTP hydrolysis, nor is it known when GBF is released from the nascent COPI vesicle.
20637885 Pubmed 2011 Models for the functions of Arf GAPs East, Michael P Kahn, Richard A Semin. Cell Dev. Biol. 22:3-9 19631211 Pubmed 2009 The COPI system: molecular mechanisms and function Beck, R Rawet, M Ravet, M Wieland, Felix T Cassel, Dan FEBS Lett. 583:2701-9 8253837 Pubmed 1993 Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles Tanigawa, G Orci, L Amherdt, M Ravazzola, M Helms, J B Rothman J E J. Cell Biol. 123:1365-71 LEFT-TO-RIGHT cis-Golgi cis-SNARE binds NSF and SNAPs This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp cis-Golgi cis SNARE bundle Reactome DB_ID: 10727224 Golgi membrane GENE ONTOLOGY GO:0000139 ykt6 PalmC-YKT6 O60073 Reactome DB_ID: 10727110 1 EQUAL 196 EQUAL Reactome Database ID Release 77 10727110 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727110 Reactome R-SPO-6808792 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808792.1 1 Converted from EntitySet in Reactome cis-Golgi t-SNARES Reactome DB_ID: 10727220 GOSR1:BET1L:STX5 Reactome DB_ID: 10727212 Converted from EntitySet in Reactome Homologues of BET1L Reactome DB_ID: 10727208 bet1 BET1L O13932 Reactome DB_ID: 10727201 1 EQUAL 111 EQUAL Reactome Database ID Release 77 10727201 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727201 Reactome R-SPO-6807744 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807744.1 sft1 BET1L Q09730 Reactome DB_ID: 10727206 UniProt:Q09730 sft1 UniProt Q09730 1 EQUAL 111 EQUAL Reactome Database ID Release 77 10727206 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727206 Reactome R-SPO-6807744-2 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807744-2.1 Reactome Database ID Release 77 10727208 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727208 Reactome R-SPO-6807744-3 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807744-3.1 1 gos1 GOSR1 Q09835 Reactome DB_ID: 10727199 UniProt:Q09835 gos1 UniProt Q09835 2 EQUAL 250 EQUAL Reactome Database ID Release 77 10727199 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727199 Reactome R-SPO-6807753 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807753.1 1 sed5 STX5 O13644 Reactome DB_ID: 10727210 1 EQUAL 355 EQUAL Reactome Database ID Release 77 10727210 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727210 Reactome R-SPO-6807771 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807771.1 1 Reactome Database ID Release 77 10727212 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727212 Reactome R-SPO-6807794 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807794.1 GOSR1:GOSR2:STX5 Reactome DB_ID: 10727216 1 bos1 GOSR2 Q9P7G5 Reactome DB_ID: 10727214 1 EQUAL 212 EQUAL Reactome Database ID Release 77 10727214 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727214 Reactome R-SPO-6807755 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807755.1 1 1 Reactome Database ID Release 77 10727216 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727216 Reactome R-SPO-6807795 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807795.1 GOSR1:BET1:STX5 Reactome DB_ID: 10727218 bet1 BET1 O13932 Reactome DB_ID: 10727182 1 EQUAL 118 EQUAL Reactome Database ID Release 77 10727182 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727182 Reactome R-SPO-6807743 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807743.1 1 1 1 Reactome Database ID Release 77 10727218 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727218 Reactome R-SPO-6807791 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807791.1 Reactome Database ID Release 77 10727220 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727220 Reactome R-SPO-6807834 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6807834.1 1 Reactome Database ID Release 77 10727224 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727224 Reactome R-SPO-6809000 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6809000.1 3 cis-SNARE:3xSNAP:NSF hexamer Reactome DB_ID: 10727226 1 1 3 Reactome Database ID Release 77 10727226 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727226 Reactome R-SPO-6808999 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6808999.1 Reactome Database ID Release 77 10727228 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10727228 Reactome r -热点- 6809014 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-6809014.1 After membrane fusion, the cis-SNARE complex is dissociated in an ATP-dependent fashion by the AAA protein NSF in conjunction with SNAP proteins (Mayer et al, 1996; Sollner et al, 1993; reviewed in Jahn and Scheller, 2006; Sudhof and Rothman, 2009). LEFT-TO-RIGHT 3.6.1.3 NSF ATPase activity dissociates cis-SNARE at cis-Golgi This event has been computationally inferred from an event that has been demonstrated in another species.