BioPAX pathway converted from "Centrosome maturation" in the Reactome database. Centrosome maturation This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Recruitment of mitotic centrosome proteins and complexes This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp LEFT-TO-RIGHT Recruitment of CDK11p58 to the centrosomes This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Converted from EntitySet in Reactome CDK11p58 ReactomeDB_ID: 9978484 CDK11B LOC489591 E2R4W7 ReactomeDB_ID: 9978480 cytosol GENE ONTOLOGY GO:0005829 UniProt:E2R4W7 LOC489591 Canis familiaris NCBI Taxonomy 9615 UniProt E2R4W7 1 EQUAL 795 EQUAL ReactomeDatabase ID Release 77 9978480 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978480 Reactome R-CFA-380451 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380451.1 Reactome //www.joaskin.com ReactomeDatabase ID Release 77 9978484 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978484 Reactome R-CFA-380452 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380452.1 centrosome ReactomeDB_ID: 9978402 CKAP5 CKAP5 A0A5F4CFN6 ReactomeDB_ID: 9963418 UniProt:A0A5F4CFN6 CKAP5 UniProt A0A5F4CFN6 1 EQUAL 2032 EQUAL ReactomeDatabase ID Release 77 9963418 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963418 Reactome R-CFA-377729 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-377729.1 1 CEP290 CEP290 A0A5F4CKE1 ReactomeDB_ID: 9978302 UniProt:A0A5F4CKE1 CEP290 UniProt A0A5F4CKE1 1 EQUAL 2479 EQUAL ReactomeDatabase ID Release 77 9978302 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978302 Reactome R-CFA-380275 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380275.1 1 PCNT PCNT F1PAP3 ReactomeDB_ID: 9978234 UniProt:F1PAP3 PCNT UniProt F1PAP3 1 EQUAL 3336 EQUAL ReactomeDatabase ID Release 77 9978234 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978234 Reactome R-CFA-380290 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380290.1 1 AZI1 CEP131 F6Y5E4 ReactomeDB_ID: 9978314 UniProt:F6Y5E4 CEP131 UniProt F6Y5E4 1 EQUAL 1083 EQUAL ReactomeDatabase ID Release 77 9978314 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978314 Reactome R-CFA-380295 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380295.1 1 CEP250 CEP250 J9P5Q1 ReactomeDB_ID: 9978258 UniProt:J9P5Q1 CEP250 UniProt J9P5Q1 1 EQUAL 2442 EQUAL ReactomeDatabase ID Release 77 9978258 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978258 Reactome R-CFA-380263 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380263.1 1 CEP57 CEP57 A0A5F4CNL5 ReactomeDB_ID: 9978348 UniProt:A0A5F4CNL5 CEP57 UniProt A0A5F4CNL5 1 EQUAL 500 EQUAL ReactomeDatabase ID Release 77 9978348 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978348 Reactome R-CFA-380271 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380271.1 1 Ghost homologue of HSP90AA1 ReactomeDB_ID: 9978204 ReactomeDatabase ID Release 77 9978204 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978204 Reactome R-CFA-192864 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-192864.1 1 NEDD1 NEDD1 E2R5C6 ReactomeDB_ID: 9978200 UniProt:E2R5C6 NEDD1 UniProt E2R5C6 1 EQUAL 660 EQUAL ReactomeDatabase ID Release 77 9978200 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978200 Reactome R-CFA-379267 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-379267.1 1 CSNK1D CSNK1D F1Q126 ReactomeDB_ID: 9978222 UniProt:F1Q126 CSNK1D UniProt F1Q126 1 EQUAL 415 EQUAL ReactomeDatabase ID Release 77 9978222 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978222 Reactome R-CFA-380315 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380315.1 1 F1PGY9 DYNC1H1 DYNC1H1 ReactomeDB_ID: 9963584 UniProt:F1PGY9 DYNC1H1 UniProt F1PGY9 1 EQUAL 4646 EQUAL ReactomeDatabase ID Release 77 9963584 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963584 Reactome R-CFA-380285 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380285.1 1 CENPJ CENPJ E2QWE2 ReactomeDB_ID: 9978262 UniProt:E2QWE2 CENPJ UniProt E2QWE2 1 EQUAL 1338 EQUAL ReactomeDatabase ID Release 77 9978262 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978262 Reactome R-CFA-380291 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380291.1 1 CCP110 CCP110 A0A5F4C0Q8 ReactomeDB_ID: 9978322 UniProt:A0A5F4C0Q8 CCP110 UniProt A0A5F4C0Q8 1 EQUAL 1012 EQUAL ReactomeDatabase ID Release 77 9978322 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978322 Reactome R-CFA-380261 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380261.1 1 CEP152 CEP152 J9P002 ReactomeDB_ID: 9978310 UniProt:J9P002 CEP152 UniProt J9P002 1 EQUAL 1654 EQUAL ReactomeDatabase ID Release 77 9978310 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978310 Reactome R-CFA-380277 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380277.1 1 OFD1 OFD1 A0A5F4CXY9 ReactomeDB_ID: 9978318 UniProt:A0A5F4CXY9 OFD1 UniProt A0A5F4CXY9 1 EQUAL 1012 EQUAL ReactomeDatabase ID Release 77 9978318 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978318 Reactome R-CFA-380318 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380318.1 1 MAPRE1 A0A5F4DGZ4 ReactomeDB_ID: 9963306 UniProt:A0A5F4DGZ4 UniProt A0A5F4DGZ4 2 EQUAL 268 EQUAL ReactomeDatabase ID Release 77 9963306 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963306 Reactome R-CFA-376240 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-376240.1 1 CSNK1E CSNK1E A0A5F4CST1 ReactomeDB_ID: 9978226 UniProt:A0A5F4CST1 CSNK1E UniProt A0A5F4CST1 1 EQUAL 416 EQUAL ReactomeDatabase ID Release 77 9978226 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978226 Reactome R-CFA-205877 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-205877.1 1 NEK2 NEK2 E2RSC1 ReactomeDB_ID: 9968030 UniProt:E2RSC1 NEK2 UniProt E2RSC1 1 EQUAL 445 EQUAL ReactomeDatabase ID Release 77 9968030 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968030 Reactome R-CFA-177329 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-177329.1 1 CEP192 CEP192 F6Y0J3 ReactomeDB_ID: 9978298 UniProt:F6Y0J3 CEP192 UniProt F6Y0J3 1 EQUAL 1941 EQUAL ReactomeDatabase ID Release 77 9978298 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978298 Reactome R-CFA-380319 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380319.1 1 SFI1 SFI1 J9P421 ReactomeDB_ID: 9978238 UniProt:J9P421 SFI1 UniProt J9P421 1 EQUAL 1242 EQUAL ReactomeDatabase ID Release 77 9978238 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978238 Reactome R-CFA-380265 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380265.1 1 SDCCAG8 SDCCAG8 A0A5F4D5A4 ReactomeDB_ID: 9978336 UniProt:A0A5F4D5A4 SDCCAG8 UniProt A0A5F4D5A4 1 EQUAL 713 EQUAL ReactomeDatabase ID Release 77 9978336 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978336 Reactome R-CFA-380273 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380273.1 1 CEP70 CEP70 F1PBQ5 ReactomeDB_ID: 9978344 UniProt:F1PBQ5 CEP70 UniProt F1PBQ5 1 EQUAL 597 EQUAL ReactomeDatabase ID Release 77 9978344 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978344 Reactome R-CFA-380257 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380257.1 1 PPP2R1A PPP2R1A A0A5F4CGH7 ReactomeDB_ID: 9963386 UniProt:A0A5F4CGH7 PPP2R1A UniProt A0A5F4CGH7 2 EQUAL 589 EQUAL ReactomeDatabase ID Release 77 9963386 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963386 Reactome R-CFA-165982 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-165982.1 1 PRKAR2B PRKAR2B A0A5F4D7W7 ReactomeDB_ID: 9961950 UniProt:A0A5F4D7W7 PRKAR2B UniProt A0A5F4D7W7 2 EQUAL 418 EQUAL ReactomeDatabase ID Release 77 9961950 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9961950 Reactome R-CFA-57842 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-57842.1 1 TUBB TUBB E2QSF4 ReactomeDB_ID: 9978278 extracellular region GENE ONTOLOGY GO:0005576 UniProt:E2QSF4 TUBB UniProt E2QSF4 1 EQUAL 444 EQUAL ReactomeDatabase ID Release 77 9978278 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978278 Reactome R-CFA-380317 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380317.1 1 DYNLL1 DYNLL1 A0A5F4CQ75 ReactomeDB_ID: 9963598 UniProt:A0A5F4CQ75 DYNLL1 UniProt A0A5F4CQ75 1 EQUAL 89 EQUAL ReactomeDatabase ID Release 77 9963598 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963598 Reactome R-CFA-387105 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-387105.1 1 TUBA4A TUBA4A E2RBC3 ReactomeDB_ID: 9978210 UniProt:E2RBC3 TUBA4A UniProt E2RBC3 1 EQUAL 448 EQUAL ReactomeDatabase ID Release 77 9978210 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978210 Reactome R-CFA-191694 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-191694.1 1 CEP164 CEP164 F1PB71 ReactomeDB_ID: 9978306 UniProt:F1PB71 CEP164 UniProt F1PB71 1 EQUAL 1460 EQUAL ReactomeDatabase ID Release 77 9978306 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978306 Reactome R-CFA-380305 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380305.1 1 PLK4 PLK4 E2RST5 ReactomeDB_ID: 9978270 UniProt:E2RST5 PLK4 UniProt E2RST5 1 EQUAL 970 EQUAL ReactomeDatabase ID Release 77 9978270 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978270 Reactome R-CFA-380286 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380286.1 1 CEP43 FGFR1OP A0A5F4CK14 ReactomeDB_ID: 9978356 UniProt:A0A5F4CK14 CEP43 UniProt A0A5F4CK14 1 EQUAL 399 EQUAL ReactomeDatabase ID Release 77 9978356 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978356 Reactome R-CFA-380309 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380309.1 1 DCTN3 DCTN3 E2RBC1 ReactomeDB_ID: 9978282 UniProt:E2RBC1 DCTN3 UniProt E2RBC1 1 EQUAL 186 EQUAL ReactomeDatabase ID Release 77 9978282 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978282 Reactome R-CFA-380264 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380264.1 1 TUBB4A TUBB4A E2RFV2 ReactomeDB_ID: 9978218 UniProt:E2RFV2 TUBB4A UniProt E2RFV2 1 EQUAL 444 EQUAL ReactomeDatabase ID Release 77 9978218 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978218 Reactome R-CFA-190588 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-190588.1 1 NDE1 NDE1 F6X6L7 ReactomeDB_ID: 9963330 UniProt:F6X6L7 NDE1 UniProt F6X6L7 1 EQUAL 346 EQUAL ReactomeDatabase ID Release 77 9963330 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963330 Reactome R-CFA-376257 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-376257.1 1 CEP41 CEP41 A0A5F4CXW2 ReactomeDB_ID: 9978360 UniProt:A0A5F4CXW2 CEP41 UniProt A0A5F4CXW2 1 EQUAL 373 EQUAL ReactomeDatabase ID Release 77 9978360 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978360 Reactome R-CFA-380269 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380269.1 1 PAFAH1B1 PAFAH1B1 A0A5F4BTY2 ReactomeDB_ID: 9963322 UniProt:A0A5F4BTY2 PAFAH1B1 UniProt A0A5F4BTY2 1 EQUAL 410 EQUAL ReactomeDatabase ID Release 77 9963322 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963322 Reactome R-CFA-376249 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-376249.1 1 YWHAG YWHAG J9NRH5 ReactomeDB_ID: 9959616 UniProt:J9NRH5 YWHAG UniProt J9NRH5 1 EQUAL 247 EQUAL ReactomeDatabase ID Release 77 9959616 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9959616 Reactome R-CFA-380312 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380312.1 1 Ghost homologue of CEP76 ReactomeDB_ID: 9978332 ReactomeDatabase ID Release 77 9978332 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978332 Reactome R-CFA-380281 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380281.1 1 CLASP1 CLASP1 A0A5F4BPZ8 ReactomeDB_ID: 9963298 UniProt:A0A5F4BPZ8 CLASP1 UniProt A0A5F4BPZ8 1 EQUAL 1538 EQUAL ReactomeDatabase ID Release 77 9963298 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963298 Reactome R-CFA-376230 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-376230.1 1 DCTN1 DCTN1-2 F6UMF1 ReactomeDB_ID: 9978266 UniProt:F6UMF1 DCTN1 UniProt F6UMF1 1 EQUAL 1278 EQUAL ReactomeDatabase ID Release 77 9978266 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978266 Reactome R-CFA-380301 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380301.1 1 CETN2 CETN2 F1Q156 ReactomeDB_ID: 9978230 UniProt:F1Q156 CETN2 UniProt F1Q156 1 EQUAL 172 EQUAL ReactomeDatabase ID Release 77 9978230 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978230 Reactome R-CFA-380298 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380298.1 1 CEP135 CEP135 F1PRN4 ReactomeDB_ID: 9978326 UniProt:F1PRN4 CEP135 UniProt F1PRN4 1 EQUAL 1140 EQUAL ReactomeDatabase ID Release 77 9978326 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978326 Reactome R-CFA-380266 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380266.1 1 Ghost homologue of TUBG1 ReactomeDB_ID: 9978202 ReactomeDatabase ID Release 77 9978202 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978202 Reactome R-CFA-379269 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-379269.1 1 ACTR1A ACTR1A P61162 ReactomeDB_ID: 9978286 UniProt:P61162 ACTR1A UniProt P61162 1 EQUAL 376 EQUAL ReactomeDatabase ID Release 77 9978286 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978286 Reactome R-CFA-380258 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380258.1 1 PLK1 PLK1 J9P0Q4 ReactomeDB_ID: 9963406 UniProt:J9P0Q4 PLK1 UniProt J9P0Q4 1 EQUAL 603 EQUAL ReactomeDatabase ID Release 77 9963406 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963406 Reactome R-CFA-164603 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-164603.1 1 ODF2 ODF2 E2RSU2 ReactomeDB_ID: 9978274 UniProt:E2RSU2 ODF2 UniProt E2RSU2 1 EQUAL 829 EQUAL ReactomeDatabase ID Release 77 9978274 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978274 Reactome R-CFA-380293 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380293.1 1 ALMS1 ALMS1 A0A5F4CN94 ReactomeDB_ID: 9978294 UniProt:A0A5F4CN94 ALMS1 UniProt A0A5F4CN94 1 EQUAL 4167 EQUAL ReactomeDatabase ID Release 77 9978294 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978294 Reactome R-CFA-380289 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380289.1 1 HAUS complex ReactomeDB_ID: 9978400 Ghost homologue of HAUS4 ReactomeDB_ID: 9978382 ReactomeDatabase ID Release 77 9978382 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978382 Reactome R-CFA-8855202 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8855202.1 1 HAUS5 HAUS5 A0A5F4BVD3 ReactomeDB_ID: 9978386 UniProt:A0A5F4BVD3 HAUS5 UniProt A0A5F4BVD3 1 EQUAL 633 EQUAL ReactomeDatabase ID Release 77 9978386 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978386 Reactome R-CFA-8855197 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8855197.1 1 HAUS7 HAUS7 A0A5F4CJF6 ReactomeDB_ID: 9978394 UniProt:A0A5F4CJF6 HAUS7 UniProt A0A5F4CJF6 1 EQUAL 368 EQUAL ReactomeDatabase ID Release 77 9978394 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978394 Reactome R-CFA-8855200 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8855200.1 1 HAUS1 HAUS1 A0A5F4CNS2 ReactomeDB_ID: 9978372 UniProt:A0A5F4CNS2 HAUS1 UniProt A0A5F4CNS2 1 EQUAL 278 EQUAL ReactomeDatabase ID Release 77 9978372 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978372 Reactome R-CFA-8855199 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8855199.1 1 HAUS8 HAUS8 A0A5F4C8Y2 ReactomeDB_ID: 9978398 UniProt:A0A5F4C8Y2 HAUS8 UniProt A0A5F4C8Y2 2 EQUAL 410 EQUAL ReactomeDatabase ID Release 77 9978398 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978398 Reactome R-CFA-8855198 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8855198.1 1 HAUS2 HAUS2 E2R4Y8 ReactomeDB_ID: 9978376 UniProt:E2R4Y8 HAUS2 UniProt E2R4Y8 1 EQUAL 235 EQUAL ReactomeDatabase ID Release 77 9978376 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978376 Reactome R-CFA-380274 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380274.1 1 HAUS6 HAUS6 E2RP27 ReactomeDB_ID: 9978390 UniProt:E2RP27 HAUS6 UniProt E2RP27 1 EQUAL 955 EQUAL ReactomeDatabase ID Release 77 9978390 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978390 Reactome R-CFA-8855196 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8855196.1 1 HAUS3 HAUS3 F1PDJ8 ReactomeDB_ID: 9978380 UniProt:F1PDJ8 HAUS3 UniProt F1PDJ8 2 EQUAL 603 EQUAL ReactomeDatabase ID Release 77 9978380 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978380 Reactome R-CFA-8855201 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8855201.1 1 ReactomeDatabase ID Release 77 9978400 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978400 Reactome R-CFA-8855211 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8855211.1 1 Ghost homologue of TUBA1A ReactomeDB_ID: 9978206 ReactomeDatabase ID Release 77 9978206 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978206 Reactome R-CFA-191689 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-191689.1 1 YWHAE YWHAE A0A5F4CPW0 ReactomeDB_ID: 9959652 UniProt:A0A5F4CPW0 YWHAE UniProt A0A5F4CPW0 1 EQUAL 255 EQUAL ReactomeDatabase ID Release 77 9959652 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9959652 Reactome R-CFA-194368 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-194368.1 1 CNTRL CNTRL A0A5F4C7X0 ReactomeDB_ID: 9978250 UniProt:A0A5F4C7X0 CNTRL UniProt A0A5F4C7X0 1 EQUAL 2325 EQUAL ReactomeDatabase ID Release 77 9978250 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978250 Reactome R-CFA-380256 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380256.1 1 DYNC1I2 DYNC1I2 A0A5F4CZW1 ReactomeDB_ID: 9963594 UniProt:A0A5F4CZW1 DYNC1I2 UniProt A0A5F4CZW1 1 EQUAL 638 EQUAL ReactomeDatabase ID Release 77 9963594 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963594 Reactome R-CFA-201607 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201607.1 1 F1PBT2 CDK5RAP2 CDK5RAP2 ReactomeDB_ID: 9978246 UniProt:F1PBT2 CDK5RAP2 UniProt F1PBT2 1 EQUAL 1893 EQUAL ReactomeDatabase ID Release 77 9978246 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978246 Reactome R-CFA-380282 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380282.1 1 CEP63 CEP63 A0A5F4DN79 ReactomeDB_ID: 9978352 UniProt:A0A5F4DN79 CEP63 UniProt A0A5F4DN79 1 EQUAL 703 EQUAL ReactomeDatabase ID Release 77 9978352 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978352 Reactome R-CFA-380267 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380267.1 1 CEP72 CEP72 F1PXT4 ReactomeDB_ID: 9978340 UniProt:F1PXT4 CEP72 UniProt F1PXT4 1 EQUAL 647 EQUAL ReactomeDatabase ID Release 77 9978340 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978340 Reactome R-CFA-380321 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380321.1 1 TUBB4B TUBB4B A0A5F4BWF5 ReactomeDB_ID: 9978214 UniProt:A0A5F4BWF5 TUBB4B UniProt A0A5F4BWF5 1 EQUAL 445 EQUAL ReactomeDatabase ID Release 77 9978214 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978214 Reactome R-CFA-191702 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-191702.1 1 PCM1 PCM1 A0A5F4C8D4 ReactomeDB_ID: 9978254 UniProt:A0A5F4C8D4 PCM1 UniProt A0A5F4C8D4 1 EQUAL 2024 EQUAL ReactomeDatabase ID Release 77 9978254 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978254 Reactome R-CFA-380308 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380308.1 1 DCTN2 DCTN2 A0A5F4C6E4 ReactomeDB_ID: 9978290 UniProt:A0A5F4C6E4 DCTN2 UniProt A0A5F4C6E4 2 EQUAL 401 EQUAL ReactomeDatabase ID Release 77 9978290 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978290 Reactome R-CFA-380302 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380302.1 1 CDK1 CDK1 E2RGJ9 ReactomeDB_ID: 9966273 UniProt:E2RGJ9 CDK1 UniProt E2RGJ9 1 EQUAL 297 EQUAL ReactomeDatabase ID Release 77 9966273 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9966273 Reactome R-CFA-170075 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-170075.1 1 NINL NINL E2RIK2 ReactomeDB_ID: 9978368 UniProt:E2RIK2 NINL UniProt E2RIK2 1 EQUAL 1382 EQUAL ReactomeDatabase ID Release 77 9978368 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978368 Reactome R-CFA-380706 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380706.1 1 PRKACA PRKACA A0A5F4CHW2 ReactomeDB_ID: 9961956 UniProt:A0A5F4CHW2 PRKACA UniProt A0A5F4CHW2 2 EQUAL 351 EQUAL ReactomeDatabase ID Release 77 9961956 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9961956 Reactome R-CFA-57844 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-57844.1 1 SSNA1 SSNA1 E2R7E3 ReactomeDB_ID: 9978364 UniProt:E2R7E3 SSNA1 UniProt E2R7E3 1 EQUAL 119 EQUAL ReactomeDatabase ID Release 77 9978364 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978364 Reactome R-CFA-380255 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380255.1 1 CEP78 CEP78 A0A5F4D526 ReactomeDB_ID: 9978330 UniProt:A0A5F4D526 CEP78 UniProt A0A5F4D526 1 EQUAL 689 EQUAL ReactomeDatabase ID Release 77 9978330 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978330 Reactome R-CFA-380304 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380304.1 1 AKAP9 AKAP9 A0A5F4CRG5 ReactomeDB_ID: 9978242 UniProt:A0A5F4CRG5 AKAP9 UniProt A0A5F4CRG5 1 EQUAL 3911 EQUAL ReactomeDatabase ID Release 77 9978242 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978242 Reactome R-CFA-380260 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380260.1 1 ReactomeDatabase ID Release 77 9978402 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978402 Reactome R-CFA-380268 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380268.1 Centrosomes containing recruited CDK11p58 ReactomeDB_ID: 9978489 1 1 ReactomeDatabase ID Release 77 9978489 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978489 Reactome R-CFA-380453 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380453.1 ReactomeDatabase ID Release 77 9978491 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978491 Reactome R-CFA-380455 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380455.1 CDK11p58 is a kinase that is active during mitosis when it associates with centrosomes, and has a crucial role in centrosome maturation and bipolar spindle formation (Petretti et al., 2006). CDK11p58 facilitates microtubule nucleation and is required for the recruitment of Aurora and Plk1 to the centrosome (Petretti et al., 2006). 16462731 Pubmed 2006 The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation Petretti, C Savoian, M Montembault, E Glover, DM Prigent, C Giet, R EMBO Rep 7:418-24 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT Recruitment of Plk1 to centrosomes This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Centrosome associated Plk1 ReactomeDB_ID: 9978476 1 1 ReactomeDatabase ID Release 77 9978476 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978476 Reactome R-CFA-380288 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380288.1 ReactomeDatabase ID Release 77 9978486 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978486 Reactome R-CFA-380311 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380311.1 Plk1 is associated with the centrosomes early in mitosis (Golsteyn et al. 1995). Plk1 activity is necessary for the maturation of centrosomes at the G2/M transition and the establishment of a bipolar spindle (Lane and Nigg 1996). Specific inhibitors against Plk1 or silencing of Plk1 produce a monopolar mitotic apparatus (Sumara et al, 2004, van Vugt et al, 2004, McInnes et al, 2006, Peters et al, 2006, Lénárt et al, 2007). 7790358 Pubmed 1995 Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function Golsteyn, RM Mundt, KE Fry, AM Nigg, EA J Cell Biol 129:1617-28 8991084 Pubmed 1996 Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes Lane, HA Nigg, EA J Cell Biol 135:1701-13 15458642 Pubmed 2004 Roles of polo-like kinase 1 in the assembly of functional mitotic spindles Sumara, I Giménez-Abián, Juan F Gerlich, D Hirota, T Kraft, C de la Torre, C Ellenberg, J Peters, JM Curr Biol 14:1712-22 15210710 Pubmed 2004 Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis van Vugt, MA van de Weerdt, BC Vader, G Janssen, H Calafat, J Klompmaker, R Wolthuis, RM Medema, RH J Biol Chem 279:36841-54 17291761 Pubmed 2007 The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1 Lénárt, P Petronczki, M Steegmaier, M Di Fiore, B Lipp, JJ Hoffmann, M Rettig, WJ Kraut, N Peters, JM Curr Biol 17:304-15 17028581 Pubmed 2006 Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance McInnes, C Mazumdar, A Mezna, M Meades, C Midgley, C Scaerou, F Carpenter, L Mackenzie, M Taylor, P Walkinshaw, M Fischer, PM Glover, D Nat Chem Biol 2:608-17 17028580 Pubmed 2006 Probing cell-division phenotype space and Polo-like kinase function using small molecules Peters, U Cherian, J Kim, JH Kwok, BH Kapoor, TM Nat Chem Biol 2:618-26 ACTIVATION ReactomeDatabase ID Release 77 9978487 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978487 LEFT-TO-RIGHT Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp gamma-tubulin complex ReactomeDB_ID: 9978462 gamma-TuSC ReactomeDB_ID: 9978448 TUBGCP3 TUBGCP3 A0A5F4CK27 ReactomeDB_ID: 9978446 UniProt:A0A5F4CK27 TUBGCP3 UniProt A0A5F4CK27 1 EQUAL 907 EQUAL ReactomeDatabase ID Release 77 9978446 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978446 Reactome R-CFA-379276 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-379276.1 1 TUBG2 LOC100856176 E2RD85 ReactomeDB_ID: 9978438 UniProt:E2RD85 LOC100856176 UniProt E2RD85 1 EQUAL 451 EQUAL ReactomeDatabase ID Release 77 9978438 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978438 Reactome R-CFA-379272 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-379272.1 1 TUBGCP2 TUBGCP2 A0A5F4DK90 ReactomeDB_ID: 9978442 UniProt:A0A5F4DK90 TUBGCP2 UniProt A0A5F4DK90 1 EQUAL 902 EQUAL ReactomeDatabase ID Release 77 9978442 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978442 Reactome R-CFA-379275 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-379275.1 1 1 ReactomeDatabase ID Release 77 9978448 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978448 Reactome R-CFA-380447 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380447.1 6 NME7 NME7 F1PMF2 ReactomeDB_ID: 9978460 UniProt:F1PMF2 NME7 UniProt F1PMF2 1 EQUAL 376 EQUAL ReactomeDatabase ID Release 77 9978460 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978460 Reactome R-CFA-6806880 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6806880.1 1 E2RSA5 TUBGCP4 TUBGCP4 ReactomeDB_ID: 9978426 UniProt:E2RSA5 TUBGCP4 UniProt E2RSA5 1 EQUAL 667 EQUAL ReactomeDatabase ID Release 77 9978426 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978426 Reactome R-CFA-379268 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-379268.1 1 MZT1 MZT1 A0A5F4CJS6 ReactomeDB_ID: 9978452 UniProt:A0A5F4CJS6 MZT1 UniProt A0A5F4CJS6 2 EQUAL 82 EQUAL ReactomeDatabase ID Release 77 9978452 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978452 Reactome R-CFA-8955055 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8955055.1 1 E2RS78 TUBGCP6 TUBGCP6 ReactomeDB_ID: 9978434 UniProt:E2RS78 TUBGCP6 UniProt E2RS78 1 EQUAL 1819 EQUAL ReactomeDatabase ID Release 77 9978434 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978434 Reactome R-CFA-379274 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-379274.1 1 1 TUBGCP5 TUBGCP5 A0A5F4DFN4 ReactomeDB_ID: 9978430 UniProt:A0A5F4DFN4 TUBGCP5 UniProt A0A5F4DFN4 1 EQUAL 1024 EQUAL ReactomeDatabase ID Release 77 9978430 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978430 Reactome R-CFA-379271 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-379271.1 1 MZT2B MZT2A A0A5F4CQF3 ReactomeDB_ID: 9978456 UniProt:A0A5F4CQF3 MZT2B UniProt A0A5F4CQF3 1 EQUAL 158 EQUAL ReactomeDatabase ID Release 77 9978456 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978456 Reactome R-CFA-8955056 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8955056.1 2 ReactomeDatabase ID Release 77 9978462 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978462 Reactome R-CFA-379277 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-379277.1 Mature centrosomes enriched in gamma-TURC complexes ReactomeDB_ID: 9978464 1 1 ReactomeDatabase ID Release 77 9978464 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978464 Reactome R-CFA-380440 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380440.1 ReactomeDatabase ID Release 77 9978466 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978466 Reactome R-CFA-380283 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380283.1 中心体是mediat微管成核ed by the gamma tubulin ring complex (gamma TuRC) (reviewed in Raynaud-Messina and Merdes, 2006; Wiese and Zheng, 2006). In humans, this large complex contains the tubulin superfamily member gamma-tubulin, five gamma complex proteins (GCP2-GPC6) and NEDD1/GCP-WD. A current model of the arrangement of subunits within the gamma-TuRC proposes that 6-7 TuSC subcomplexes are held together by the other Grip proteins (at an unknown stoichiometry), which together form the cap subunits. In many animal cells, the recruitment of gamma-tubulin complexes to the centrosome rapidly increases (3–5 fold ) before mitosis to support the formation of new spindle microtubules (Khodjakov and Rieder 1999). NEDD1/GCP-WD plays an essential role in recruitment of these complexes to the centrosomes (Haren et al., 2006; Luders et al., 2006) and to the mitotic spindle (Luders et al., 2006). GCP-WD/NEDD1 associates directly with the gamma-TuRC. The carboxy-terminal half binds to the gamma-TuRC whereas the amino-terminal half, corresponding to the WD-repeat domain, is responsible for its attachment to the centrosome (Haren et al., 2006). Additional centrosomal proteins have also been implicated in the docking of gamma-TuRC to the centrosomes. CG-NAP/AKAP450 and kendrin are necessary for the initiation of microtubule nucleation and interact with GCP2/GCP3 and GCP2, respectively (Takahashi et al., 2002). Pericentrin plays an important role in microtubule organization in mitotic cells and anchors gamma- TuRC through domains that bind GCP2 and GCP3 (Zimmerman et al. 2004). Ninein localizes to the centriole via its C-terminus and interacts with gamma-tubulin-containing complexes via its N-terminus.

Nucleoside diphosphate kinase (NME7) is a poorly characterised member of the NME family and has been observed to exhibit no NADPK activity (Yoon et al. 2005, Liu et al. 2014). NME7 has recently been found to be a component of the γ-tubulin ring complex (γTuRC) where it regulates the microtubule-nucleating activity (the event that initiates de novo formation of microtubules) of the γTuRC. NME7 contains two putative kinase domains, A and B; domain A is involved in autophosphorylation whereas domain B is inactive. NME7 interacts with the γTuRC through both domains, with Arg-322 in domain B being critical for binding. In association with the γTuRC, NME7 localizes to centrosomes throughout the cell cycle and to mitotic spindles during mitosis (Liu et al. 2014). 16461362 Pubmed 2006 NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly Haren, L Remy, MH Bazin, I Callebaut, I Wright, M Merdes, Andeas J Cell Biol 172:505-15 17178454 Pubmed 2007 Gamma-tubulin complexes and microtubule organization Raynaud-Messina, B Merdes, Andeas Curr Opin Cell Biol 19:24-30 15146056 Pubmed 2004 Mitosis-specific anchoring of gamma tubulin complexes by pericentrin controls spindle organization and mitotic entry Zimmerman, WC Sillibourne, J Rosa, J Doxsey, SJ Mol Biol Cell 15:3642-57 24807905 Pubmed 2014 NME7 is a functional component of the γ-tubulin ring complex Liu, Pengfei Choi, Yuk-Kwan Qi, Robert Z Mol. Biol. Cell 25:2017-25 10444067 Pubmed 1999 The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules Khodjakov, A Rieder, CL J Cell Biol 146:585-96 17038541 Pubmed 2006 Microtubule nucleation: gamma-tubulin and beyond Wiese, C Zheng, Y J Cell Sci 119:4143-53 12221128 Pubmed 2002 Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex Takahashi, M Yamagiwa, A Nishimura, T Mukai, H Ono, Y Mol Biol Cell 13:3235-45 16313181 Pubmed 2005 Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues Yoon, Jung-Hoon Singh, Purnima Lee, Dong-Hyun Qiu, Junzhuan Cai, Sheng O'Connor, Timothy R Chen, Yuan Shen, Binghui Pfeifer, Gerd P Biochemistry 44:15774-86 16378099 Pubmed 2006 GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation Lüders, J Patel, UK Stearns, T Nat Cell Biol 8:137-47 ReactomeDatabase ID Release 77 10045403 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10045403 Reactome R-CFA-380270 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380270.1 The mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centrosomes recruiting additional gamma TuRC complexes and acquiring mitosis-associated centrosomal proteins including NuMA, Plk1 and CDK11p58 (reviewed in Schatten 2008; Raynaud-Messina and Merdes 2007). 18437411 Pubmed 2008 The mammalian centrosome and its functional significance Schatten, H Histochem Cell Biol 129:667-86 Loss of proteins required for interphase microtubule organization from the centrosome This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp LEFT-TO-RIGHT Loss of C-Nap-1 from centrosomes This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp cNAP-1 depleted centrosome ReactomeDB_ID: 9978468 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ReactomeDatabase ID Release 77 9978468 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978468 Reactome R-CFA-380698 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380698.1 ReactomeDatabase ID Release 77 9978470 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978470 Reactome R-CFA-380294 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380294.1 The centrosomal protein C-Nap1 is thought to play an important role in centrosome cohesion during interphase (Fry et al.,1998). At the onset of mitosis, when centrosomes separate to form the bipolar spindle, C-Nap1 dissociates (Mayor et al., 2000). Dissociation of C-Nap1 from mitotic centrosomes appears to be regulated by phosphorylation (Mayor et al. 2002). 11076968 Pubmed 2000 The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion Mayor, T Stierhof, YD Tanaka, K Fry, AM Nigg, EA J Cell Biol 151:837-46 12140259 Pubmed 2002 The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles Mayor, T Hacker, U Stierhof, YD Nigg, EA J Cell Sci 115:3275-84 9647649 Pubmed 1998 C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 Fry, AM Mayor, T Meraldi, P Stierhof, YD Tanaka, K Nigg, EA J Cell Biol 141:1563-74 Loss of Nlp from mitotic centrosomes This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp LEFT-TO-RIGHT 2.7.11 Plk1-mediated phosphorylation of Nlp This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp 三磷酸腺苷 Adenosine 5'-triphosphate 三磷酸腺苷(4-) ReactomeDB_ID: 113592 三磷酸腺苷(4-) [ChEBI:30616] 三磷酸腺苷(4-) 三磷酸腺苷 atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 ReactomeDatabase ID Release 77 113592 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 additional information MI MI:0361 ADP Adenosine 5'-diphosphate ADP(3-) ReactomeDB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 ReactomeDatabase ID Release 77 29370 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 centrosome containing phosphorylated Nlp ReactomeDB_ID: 9978407 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 p-NINL phospho-NINL E2RIK2 ReactomeDB_ID: 9978405 phosphorylated residue MOD MOD:00696 1 EQUAL 1382 EQUAL ReactomeDatabase ID Release 77 9978405 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978405 Reactome R-CFA-380716 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380716.1 1 1 1 1 1 ReactomeDatabase ID Release 77 9978407 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978407 Reactome R-CFA-380704 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380704.1 ACTIVATION J9P0Q4 phospho-PLK1 p-T210-PLK1 ReactomeDB_ID: 9963680 210 EQUAL O-phospho-L-threonine MOD MOD:00047 1 EQUAL 603 EQUAL ReactomeDatabase ID Release 77 9963680 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963680 Reactome R-CFA-3000318 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3000318.1 GENE ONTOLOGY GO:0004674 对细胞功能基因本体术语 MI MI:0355 Same Catalyst Activity ReactomeDatabase ID Release 77 9963681 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963681 ReactomeDatabase ID Release 77 9978409 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978409 Reactome R-CFA-380272 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380272.1 Phosphorylation of NlP by Plk1 regulates the interaction of Nlp with both centrosomes and ?-TuRCs (Casenghi et al., 2003). 12852856 Pubmed 2003 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation Casenghi, M Meraldi, P Weinhart, U Duncan, PI Körner, R Nigg, EA Dev Cell 5:113-25 LEFT-TO-RIGHT Dissociation of Phospho-Nlp from the centrosome This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Nlp-depleted centrosome ReactomeDB_ID: 9978472 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ReactomeDatabase ID Release 77 9978472 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978472 Reactome R-CFA-380705 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380705.1 ReactomeDatabase ID Release 77 9978474 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9978474 Reactome R-CFA-380303 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380303.1 Mitotic activation of Plk1 is required for efficient displacement of Nlp from the centrosome (Casenghi et al., 2003). ReactomeDatabase ID Release 77 10045395 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10045395 Reactome R-CFA-380259 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380259.1 在间期,Nlp与gamma-tubuli交互n ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated at the onset of mitosis and phosphorylates Nlp triggering its displacement from the centrosome (Casenghi et al.,2003). Removal of Nlp appears to contribute to the establishment of a mitotic scaffold with enhanced microtubule nucleation activity. ReactomeDatabase ID Release 77 10045397 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10045397 Reactome R-CFA-380284 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380284.1 In addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization and centrosome cohesion (Casenghi et al., 2003; Mayor et al., 2002). ReactomeDatabase ID Release 77 10045399 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10045399 Reactome R-CFA-380287 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380287.1 The centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an early event in this process and involves a major reorganization of centrosomal material at the G2/M transition. During maturation, centrosomes undergo a dramatic increase in size and microtubule nucleating capacity. As part of this process, a number of proteins and complexes, including some that are required for microtubule nucleation and anchoring, are recruited to the centrosome while others that are required for organization of interphase microtubules and centrosome cohesion are lost (reviewed in Schatten, 2008; Raynaud-Messina and Merdes 2007).