在Reactome数据库中，BioPAX途径由“Kcnma1:Kcnmb1转运钾离子从胞质到胞外区域”转化而来。 Kcnma1:Kcnmb1将钾离子从胞质转运到胞外区域 Kcnma1:Kcnmb1将钾离子从胞质转运到胞外区域 外毛细胞(OHCs)中的大钾电流通道(BK通道，Kcnma1的四聚体:Kcnmb1)在钙离子流入时打开，从而导致钾离子外流，使OHC超极化并阻止OHC收缩(Langer et al. 2003, Rohmann et al. 2015)。 作者:梅，布鲁斯，2019-11-16 评论:Furness, David N, 2020-09-14 评论:达洛斯，彼得，2020年09月14日 编辑:梅，布鲁斯，2019-11-16 Reactome DB_ID: 29804 1 胞质 去 0005829 钾(1 +)(ChEBI: 29103) 钾(1 +) K + 钾 Reactome //www.joaskin.com ChEBI 29103 Reactome DB_ID: 74126 1 细胞外区域 去 0005576 PHYSIOL-LEFT-TO-RIGHT 激活 Reactome DB_ID: 9667786 等离子体膜 去 0005886 Kcnma1: Kcnmb1(质膜) Kcnma1: Kcnmb1 反应DB_ID：9667778 1 UniProt: Q62976 Kcnma1 Kcnma1 Kcnma1 Kcnma 通过膜去极化的功能钾通道，介导K（+）出口的细胞溶质Ca（2+）。它也被细胞溶质Mg（2+）的浓度激活。其激活抑制了升高细胞溶胶Ca（2+）浓度和/或去极化细胞膜的兴奋事件。因此，它有助于对膜势的复极化。在控制许多系统中控制兴奋性的关键作用，例如对平滑肌收缩的调节，在耳蜗中的毛细胞调节，发射器释放的调节以及先天免疫。在平滑的肌肉中，其在岩浆网的ryanodine受体引起的高水平Ca（2+）的活化调节膜电位。在耳蜗细胞中，其数量和动力学性质部分地确定每个毛细胞的特征频率，从而有助于建立调节型图。KCNMA1通道的动力学通过替代剪接，磷酸化状态和其与调节β亚基的组合来确定。对Iberiotoxin（IBTX）和Charybdotoxin（CTX）的高度敏感。动力调节乙醇和一氧化碳结合的血红素增加通道活化。血红素抑制频道激活。津属同源物; which constitutes the calcium-activated potassium channel. Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity. Interacts with RAB11B (By similarity).DOMAIN The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4.DOMAIN The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.DOMAIN The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).DOMAIN The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).DOMAIN The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensors regions required for activation of the channel (By similarity).DOMAIN The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation.PTM Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity (By similarity).PTM Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network (By similarity).MISCELLANEOUS The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca(2+) and Mg(2+).SIMILARITY Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. 鼠形 NCBI分类法 10116 UniProt Q62976 链坐标 1 平等的 1209 平等的 Reactome DB_ID: 9667755 1 UniProt: P97678 Kcnmb1 Kcnmb1 Kcnmb1 功能钙激活钾通道KCNMA1 (maxiK)的调控亚基。调节KCNMA1的钙敏感性和门控动力学，从而促进KCNMA1通道多样性。增加KCNMA1通道的表观Ca(2+)/电压灵敏度。它还修改了KCNMA1通道动力学和改变其药理性质。它减缓了通道的激活和失活动力学。通过提高钙离子对KCNMA1的敏感性，作为平滑肌收缩的负调控因子。它的存在也是KCNMA1通道开启剂脱氢大豆皂苷I (DHS-1)三萜苷内结合和激动剂激素17- β -雌二醇(E2)外结合的必要条件。增加charybdotoxin (CTX)毒素与KCNMA1 peptide blocker的结合活性，通过增加CTX的结合率和降低解离率(通过相似性)。亚单位与KCNMA1四聚体相互作用。每个KCNMA1四聚体可能有4个KCMNB1分子(通过相似性)。组织特异性弱表达。在大脑中，它也在表达KCNMA1的少数离散神经元中表达。天车N-glycosylated。SIMILARITY Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily. UniProt P97678 1 平等的 191 平等的 Reactome数据库ID Release 77 9667786 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=9667786 Reactome r -优化- 9667786 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-9667786.1 去 0015269 去分子功能 Reactome数据库ID Release 77 9667757 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9667757 Reactome数据库ID Release 77 9667806 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9667806 Reactome r -优化- 9667806 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-9667806.1 25653344 Pubmed 2015 耳蜗高频区外毛细胞传出突触激活BK和SK通道 Rohmann,凯文·N Wersinger,埃里克 杰里米•Braude P Pyott,索尼娅J 福克斯保罗•艾伯特 j . > 35:1821-30 12454985 Pubmed 2003年 大鼠耳蜗内Ca2+激活BK通道mRNA及其剪接变体的表达 兰格,帕特丽夏 格伦德,斯蒂芬 Rusch,阿尔方斯 J. Comp. Neurol. 455:198-209 激活 Reactome数据库ID Release 77 9667774 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9667774 Reactome DB_ID: 74016 钙(2 +)(ChEBI: 29108) 钙(2 +) ChEBI 29108