BioPAX途径由Reactome数据库中stat3上调的细胞质蛋白的表达转化而来。 stat3上调的胞质蛋白表达

stat3上调的胞质蛋白表达

转录3（STAT3）的信号传感器和活化剂是基因表达的关键调节因子，响应于许多细胞因子，包括白细胞蛋白-6（IL6），OncostatinM和白血病抑制因子。使用微阵列技术，已经报告了数百个基因作为潜在的Stat3靶基因（Dauer等，2005，Hsieh等人2005）。一些这些基因已被证明是使用基因组染色质免疫沉淀筛选的直接STAT3靶标（Snyder等，2008年，Carpenter＆Lo 2014）。通过STAT3上调的细胞质蛋白的基因包括细胞因子信号3（SOCS3）的抑制剂（SOCS3）（He等人，2003），诱导的骨髓白血病细胞分化蛋白Mcl-1（Becker等，2014），热休克蛋白Hsp 90-Alpha（HSP90AA1）（Chen等人，2007），Fascin（FSCN1）（Snyder等，2011），Vimentin（Vim）（Wu等，2004），Rho相关的GTP结合蛋白Rhou（rhou）（Schiavone等Al。2009），RAC-α丝氨酸/苏氨酸 - 蛋白激酶（AKT1）（XU等人，2005），细胞周期蛋白依赖性激酶抑制剂1（CDKN1A）（Bellido等，1998），磷脂酰肌醇3-激酶调节亚基α（Pik3R1）（Abell等人2005），信号传感器和转录激活剂1（Stat1）（Han等人2013），干扰素调节因子4（IRF4）（Durant等，2010）和一氧化氮合酶，诱导（NOS2）（lo等人。2005）。

作者:朱普，史蒂夫，2015-07-01 评论:莱博维奇，塞缪尔，2016-09-02 编辑:朱普，Steve, 2016-09-02 从Reactome中的EntitySet转换而来

Reactome DB_ID: 6790033

核浆去 0005654

胞质蛋白stat3上调基因[核质] 从Reactome中的EntitySet转换而来。每个同义词是一个PhysicalEntity的名称，每个XREF指向一个PhysicalEntity Vim基因[核质] CDKN1A基因(核浆) SOCS3基因(核浆) MCL1基因[核质] PIK3R1基因(核浆) RHOU基因(核浆) AKT1基因(核浆) STAT1基因(核浆) IRF4基因[核质] NOS2基因(核浆) HSP90AA1基因(核浆) FSCN1基因(核浆) Reactome //www.joaskin.com 智人

NCBI分类学 9606 运用 ENSG00000026025 运用 ENSG00000124762 运用 ENSG00000184557 运用 ENSG00000143384 运用 ENSG00000145675 运用 ENSG00000116574 运用 ENSG00000142208 运用 ENSG00000115415 运用 ENSG00000137265 运用 ENSG00000007171 运用 ENSG00000080824 运用 ENSG00000075618. 从Reactome中的EntitySet转换而来

Reactome DB_ID: 6790032

胞质去 0005829

stat3上调的胞质蛋白从Reactome中的EntitySet转换而来。每个同义词是一个PhysicalEntity的名称，每个XREF指向一个PhysicalEntity RHOU(胞质) akt1 [cytosol] PIK3R1(胞质) IRF4 [Cytosol] CDKN1A(胞质) Hsp90aa1 [cytosol] FSCN1(胞质) SOCS3(胞质) MCL1(胞质) NOS2(胞质) STAT1(胞质) VIM(胞质) uniprot. Q7L0Q8 uniprot. P31749 uniprot. P27986 uniprot. Q15306 uniprot. P38936 uniprot. P07900 uniprot. Q16658 uniprot. O14543. uniprot. Q07820 uniprot. P35228 uniprot. P42224 uniprot. P08670 Reactome数据库ID Release 77 6790041 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6790041 Reactome r - hsa - 6790041

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6790041.2 23455323 Pubmed 2014 突变的B-RAF-Mcl-1存活信号依赖于STAT3转录因子贝克尔,T M 博伊德,S C Mijatov B Gowrishankar，K Snoyman,年代 Pupo G M Scolyer, R 曼,G J Kefford R F 张,X维 rizo H 致癌基因33:1158 - 66 20493732 Pubmed 2010 转录因子STAT3的不同靶点有助于T细胞的致病性和稳态杜兰特,丽迪雅沃特福德,温迪T 拉莫斯，哈耶德湖劳伦斯,阿里乌斯派信徒 Vahedi,高魏,赖高桥,Hayato 太阳,Hong-Wei 菅野,Yuka 帕里,菲奥娜 o'shea，约翰j 免疫32:605-15 15950906 Pubmed 2005 EGFR和STAT3在iNOS/NO通路激活中的核相互作用瞧,Hui-Wen 许,Sheng-Chieh Ali-Seyed,默罕默德 Gunduz，Mehmet. 夏,Weiya 魏、Yongkun Bartholomeusz,杰弗里施,金苑挂,Mien-Chie 癌细胞7:575 - 89 15735721 Pubmed 2005 Stat3调节伤口愈合和癌症共同的基因多尔,Daniel J 费拉罗,伯纳黛特歌,兰溪余,本莫拉,琳达比特纳,拉尔夫 Enkemann,史蒂夫木星,理查德哈拉，埃里克B 致癌基因24:3397 - 408 22693070 Pubmed 2013 STAT1基因表达可通过EGFR和HER2与STAT3合作而增强汉族,伍迪木匠,Richard L 曹,鑫瞧,Hui-Wen 摩尔。Carcinog 52:959 - 69 24743777 Pubmed 2014 STAT3与人类癌症相关的靶基因木匠,Richard L 瞧,Hui-Wen 癌症(巴塞尔)6:897 - 925 14712222 Pubmed 2004 Stat3通过与抗沉默元件结合并与抑制蛋白ZBP-89相互作用，增强波形蛋白基因的表达吴Yongzhong 迪亚布,伊曼交给张 Izmailova,埃琳娜 Zehner Zendra E 致癌基因23:168 - 78 21937440 Pubmed 2011 信号转导和转录激活因子3 (STAT3)直接调节细胞因子诱导的筋膜蛋白表达，是乳腺癌细胞迁移所必需的斯奈德，马里林恩黄,鑫运张，J Jillian 生物。化学286:38886 - 93 18065416 Pubmed 2008 Stat3调控生长和分化的新直接靶基因的鉴定斯奈德，马里林恩黄,鑫运张，J Jillian 生物。化学283:3791-8 16081048 Pubmed 2005 stat3调控基因在人乳腺癌中的作用谢长廷,Fu-Chuan 程,龚 Jiayuh Lin, 物化学。Biophys。res。安排。335：292-9 19397496 Pubmed 2009 RHOU / WRCH1 RHO GTPASE基因是GP130 / Stat3和WNT-1途径的常见转录靶斯齐亚沃尼,大卫。 Dewilde莎拉瓦兰尼亚，弗朗切斯科 Turkson,詹姆斯 Di Cunto费迪南波里,瓦物化学。j . 421:283 - 92 17427945 Pubmed 2007 Stat1在热休克下对hsp90基因调控的不同作用陈,薛松张易王，金山李，萧妍程，小宽张,你们吴Ning-hua 沉，玉飞 J.Cell。物化学。102：1059-66 16007214 Pubmed 2005 靶向Stat3可以阻断多种致癌生长信号通路诱导的HIF-1和VEGF的表达徐，问：布里格斯，乔恩公园,Sungman 妞妞,今年 Kortylewski,戈张Shumin Gritsko,坦尼娅 Turkson,詹姆斯凯,海蒂西门,格雷格L 程,金问木星,理查德 Yu,华致癌基因24:5552-60

激活

Reactome数据库ID Release 77 6797261 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6797261 Reactome r - hsa - 6797261

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6797261.1

Reactome DB_ID: 1112525 p-Y705-STAT3二聚体(核浆)

p-Y705-STAT3二聚体

2x（p-y705-stat3）

反应DB_ID：1112554

UNIPROT：P40763 Stat3

STAT3

STAT3 APRF 函数信号转导和转录激活因子介导对白细胞介素的细胞应答，KITLG / SCF，LEP和其它生长因子（PUBMED：10688651，PUBMED：12359225，PUBMED：12873986，PUBMED：15194700，PUBMED：17344214，PUBMED：18242580，PUBMED：23084476）。一旦被激活，募集辅激活物，诸如NCOA1或MED1，与靶基因的启动子区域（PUBMED：17344214）。可介导细胞反应，激活FGFR1，FGFR2，FGFR3和FGFR4（考研：12873986）。当的IL6ST / gp130的由IL-6（IL-6）信令，结合在各种急性期蛋白基因的启动子中确定的IL6响应元件（PUBMED：12359225）的激活。通过IL31RA由IL31激活（PUBMED：15194700）。作为通过调节幼稚CD4（+）的分化的炎症反应的调节性T细胞进T-辅助的Th17或调节性T细胞（Treg）：脱乙酰化，并通过LOXL3赖氨酸残基的氧化，导致破坏STAT3二聚体化并抑制其转录活性（PUBMED：28065600）。通过诱导关键的基因的表达为从G1期进入S期，如CCND1（：17344214搜索PubMed）的进展在细胞周期调控参与。介导LEP对黑皮质素生产，身体能量稳态和哺乳期（通过相似性）的影响。可能发挥的LEP激活下transctivating BIRC5表达的细胞凋亡的作用（PUBMED：18242580）。 Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).SUBUNIT Forms a homodimer or a heterodimer with a related family member (at least STAT1) (PubMed:28065600). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1 (PubMed:15994929, PubMed:15194700, PubMed:17344214, PubMed:15677474, PubMed:15467733) (By similarity). Interacts with IL23R in presence of IL23 (PubMed:12023369). Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2 (PubMed:18234692). Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear (PubMed:17956865). Interacts with BMX (PubMed:10688651). Interacts with ZIPK/DAPK3 (PubMed:16219639). Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3 (PubMed:9388184). In prostate cancer cells, interacts with PRKCE and promotes DNA binding activity of STAT3 (PubMed:17875724). Interacts with STMN3, antagonizing its microtubule-destabilizing activity (By similarity). Interacts with the 'Lys-129' acetylated form of BIRC5/survivin (PubMed:20826784). Interacts with FER (PubMed:19147545). Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain) (PubMed:23084476). Interacts with INPP5F; the interaction is independent of STAT3 Tyr-705 phosphorylation status (PubMed:25476455). Interacts with FGFR4 (PubMed:26675719). Interacts with OCAD1 (By similarity). Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB (PubMed:31899195). Interacts and may form heterodimers with NHLH1 (By similarity).SUBUNIT (Microbial infection) Interacts with HCV core protein.SUBUNIT (Microbial infection) Interacts with S.typhimurium SarA.TISSUE SPECIFICITY Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4(+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195).PTM Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphorylation at Tyr-705 by PTK6 or FER leads to an increase of its transcriptional activity (PubMed:12763138, PubMed:16568091, PubMed:21135090). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling.PTM Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).PTM Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).PTM (Microbial infection) Phosphorylated on Tyr-705 in the presence of S.typhimurium SarA.MISCELLANEOUS Involved in the gp130-mediated signaling pathway.SIMILARITY Belongs to the transcription factor STAT family.CAUTION Was shown to be S-palmitoylated by ZDHHC19, leading to STAT3 homodimerization. However, this study was later retracted. uniprot. P40763

O4 -phospho-L-tyrosine 705

705

平等的

O4的-phospho-L-tyrosine (MOD: 00048)

链坐标

平等的

770

平等的

Reactome数据库ID Release 77 1112525 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=1112525 Reactome r - hsa - 1112525

Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-1112525.3