BioPAX途径由Reactome数据库中的“Collagen type IV binding integrin alpha10beta1”转化而来。 IV型胶原结合整合素alpha10beta1

IV型胶原结合整合素alpha10beta1

整合素alpha10beta1以相似的亲和力结合I型、IV型和VI型胶原(Tulla et al. 2001)。

作者:朱普，S, 2012-08-08 评论:richard - blum, Sylvie, 2013-08-13 编辑本文:朱斯，S, 2013-08-13 从Reactome中的EntitySet转换而来

Reactome DB_ID: 2564668

细胞外区域去 0005576

胶原IV[细胞外区] 从Reactome中的EntitySet转换而来。每个同义词是一个PhysicalEntity的名称，每个XREF指向一个PhysicalEntity Reactome //www.joaskin.com

Reactome DB_ID: 215987

等离子体膜去 0005886 整合素alpha10beta1[质膜]

整合素alpha10beta1

Reactome DB_ID: 57596

UniProt: P05556 ITGB1

ITGB1

ITGB1 MSK12 MDF2 FNRB FUNCTION整α-1 /β-1，α-2 /β-1，α--10 /β-1和α-11 /β-1是受体胶原。整α-1 /β-1和α-2 /β-2识别脯氨酸的羟基化的序列g-F-P-G-E-R中的胶原蛋白。整α-2 /β-1，α-3 /β-1，α-4- /β-1，α-5 /β-1，α-8 /β-1，α--10 /β-1，α--11 /β-1和α-V /β-1是受体纤连蛋白。α-4 /β-1识别纤连蛋白的选择性剪接的CS-1和CS-5区域内的一个或多个结构域。整合素-5 /β-1为纤维蛋白原的受体。整α-1 /β-1，α-2 /β-1，α-6 /β-1和α-7 /β-1是受体lamimin。整合素-6 /β-1（ITGA6：ITGB1）存在于卵母细胞，并参与精子 - 卵子融合（通过相似性）。整合素-4 /β-1是用于VCAM1的受体。它可以识别序列Q-I-d-S在VCAM-1。整的α-9 /β-1是用于VCAM1，cytotactin和骨桥蛋白的受体。 It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).FUNCTION (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.FUNCTION (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5.FUNCTION (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4.FUNCTION (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19.FUNCTION (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus.FUNCTION (Microbial infection) Acts as a receptor for Mammalian reovirus.FUNCTION (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.SUBUNIT Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with FLNA, FLNB and RANBP9. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (By similarity). ITGA5:ITGB1 interacts with CCN3. ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415). ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 interacts with IL1B (PubMed:29030430). ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outgrowth (PubMed:15466886). ITGA5:ITGB1 interacts with ACE2 (PubMed:33102950).SUBUNIT (Microbial infection) Integrin ITGA2:ITGB1 interacts with human echoviruses 1 and 8 capsid proteins.SUBUNIT (Microbial infection) Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB.SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus/HHV-4 gB protein.SUBUNIT (Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid protein.SUBUNIT (Microbial infection) Integrin ITGA2:ITGB1 interacts with human rotavirus VP4 protein.SUBUNIT (Microbial infection) Interacts with mammalian reovirus capsid proteins.SUBUNIT (Microbial infection) Integrin ITGA5:ITGB1 interacts with HIV-1 Tat.SUBUNIT (Microbial infection) ITGA5:ITGB1 interacts with SARS coronavirus-2/SARS-CoV-2 spike protein.PTM The cysteine residues are involved in intrachain disulfide bonds.SIMILARITY Belongs to the integrin beta chain family. 智人

NCBI分类法 9606 UniProt P05556

链坐标

平等的

798

平等的

Reactome DB_ID: 215933

UniProt: O75578 ITGA10

ITGA10

ITGA10 UNQ468 / PRO827 功能整合素-10/ -1是胶原蛋白的受体。亚基亚基和亚基的异源二聚体。α -10和β -1相关联。组织特异性广泛表达，在肌肉和心脏中表达最高。在关节软骨中发现。整合素i域(insert)是一个VWFA域。具有i结构域的整合素不发生蛋白酶裂解。相似性属于整合素链家族。 UniProt O75578

平等的

1167

平等的

Reactome数据库ID Release 77 215987 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=215987 Reactome r - hsa - 215987

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-215987.1

Reactome DB_ID: 4539778

IV型胶原网络:整合素α 10beta1[质膜]

IV型胶原网络:整合素alpha10beta1

从Reactome中的EntitySet转换而来

Reactome DB_ID: 2564668

Reactome DB_ID: 215987

Reactome数据库ID Release 77 4539778 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=4539778 Reactome r - hsa - 4539778

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4539778.1 Reactome数据库ID Release 77 4539779 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=4539779 Reactome r - hsa - 4539779

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4539779.1 11572855 Pubmed 2001 通过整合素α 1I， α 2I和α 10I域选择性结合胶原亚型 Tulla, M Pentikainen O T Viitasalo T Kapyla J Impola U Nykvist P Nissinen L 约翰逊,M S 最新信息,J 生物。化学276:48206-12