在反应数据库中，从“胰岛素样生长因子-2 mRNA结合蛋白（IGF2BPS / IMMS / VICKZS）结合RNA转化的BIoPAX途径。

胰岛素样生长因子-2 mRNA结合蛋白（IGF2BPS / IMPS / VICKZS）结合RNA

胰岛素样生长因子-2 mRNA结合蛋白(IGF2BPs)结合特定的RNA，并调节其翻译、稳定性和亚细胞定位。IGF2BP1、IGF2BP2和IGF2BP3结合了大约8400个蛋白编码转录本。靶rna包含序列基序cah(其中H为A、U或C)，与igfbp的结合增加了靶rna的稳定性。

发表于:《中国科学院院刊》2009-07-04 综述:Chao, JA, 2010-05-30 歌手，RH, 2010-05-30 编辑：5月，B，2009-07-04 IGF2BP1结合特定的rna

IGF2BP1结合特定的rna

胰岛素样生长因子mRNA结合因子-1（IGF2BP1，也称为ZBP1，CRD-BP，IMP1和VICKZ1）结合含有序列基序CAUH的几种特异性RNA（其中H是A，C或U）。结合导致RNA的稳定性和亚细胞定位。<含有引导件-3的IGF2 mRNA的同种型在5'UTR处的IGF2BP1结合，抑制翻译（IGF2的其他同种型是本要的）。
ZBP1（IGF2BP1）使用它的第三和第四kH结构域识别β肌动蛋白mRNA的3'UTR的前28个NTS。KH结构域被布置为抗并联伪二聚体，其特异性地识别位于该RNA序列中的二分元素。

MyC（C-Myc）和Beta-TRCP1 mRNA在称为编码区决定因素（CDR）的位点约束在消息的开放阅读框中。Myc mRNA的结合将其免于降解并增加其半衰期
CD44 mRNA在3'UTR中约束。
IGF2BP1还结合非编码，印迹H19 RNA。

发表于:《中国科学院院刊》2009-07-04 综述:Chao, JA, 2010-05-30 歌手，RH, 2010-05-30 编辑：5月，B，2009-07-04 从Reactome中的EntitySet转换而来

反应DB_ID：428308

cytosol. 去 0005829.

IGF2BP1结合的rna[胞质] 从Reactome中的EntitySet转换而来。每个同义词是一个PhysicalEntity的名称，每个XREF指向一个PhysicalEntity IGF2-001 mRNA [cytosol] CD44 mRNA同种型202 [cytosol] CD44 mRNA同种型205 [cytosol] H19非分量RNA [Cytosol] IGF2-002 mRNA [cytosol] CD44 mRNA同种型201 [Cytosol] CD44 mRNA同种型204 [cytosol] β -actin mRNA isoform 001[胞质] myc mRNA [cytosol] CD44 mRNA同种型203 [cytosol] Reactome http://www.reacectome.org. 智人

NCBI分类学 9606. Ensembl. ENST00000381406. Ensembl. ENST00000278385. Ensembl. ENST00000352818. Ensembl. ENST00000252900. Ensembl. ENST00000337883 Ensembl. ENST00000263398 Ensembl. ENST00000279452 Ensembl. ENST00000331789. Ensembl. ENST00000613283. Ensembl. ENST00000278386.

Reactome DB_ID: 428366

UNIPROT：Q9NZI8 IGF2BP1

IGF2BP1.

ZBP1 CRDBP Vickz1. IGF2BP1. 功能RNA结合因子促进靶转录物到细胞质蛋白-RNA复合物（MRNP）。该转录物“Caiving”进入MRNP允许MRNA运输和瞬态存储。它还调节目标转录物遇到翻译设备的速率和位置，并从内切核酸酶攻击或微小核糖介导的降解中屏蔽它们。在成人感觉神经元（相似性）中轴突再生所需的转录物的转运和翻译中起到直接作用。调节局部β-肌动蛋白/ ACTB mRNA翻译，是细胞极性，细胞迁移和神经突的关键方法。与核中的ActB mRNA共同转型相关联。该结合涉及ACTB mRNA 3'-UTR中的保守54-核苷酸元素，称为“ZIPCODE”。由此形成的RNP出口到细胞质，与电动机蛋白结合并沿着细胞骨架向细胞周边传送。在运输过程中，防止actB mRNA被翻译成蛋白质。当RNP复合物在血浆膜附近到达其目的地时，IGF2BP1磷酸化。 This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.SUBUNIT Can form homodimers and heterodimers with IGF2BP1 and IGF2BP3. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. During HCV infection, identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts (via the KH domains) with HIV-1 GAG (via the second zinc finger motif of NC). Associates (via the RRM domains and KH domains) with HIV-1 particles. Identified in a mRNP complex, composed of at least DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with DHX9, ELAVL2, HNRNPA2B1, HNRNPC, HNRNPH1, HNRNPU, IGF2BP2, ILF2, and YBX1. Interacts with FMR1. Component of a multisubunit autoregulatory RNP complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1/UNR. Directly interacts with PABPC1. Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP. Interacts with ELAVL4 in an RNA-dependent manner. Associates with microtubules and polysomes. Interacts with AGO1 and AGO2.TISSUE SPECIFICITY Mainly expressed in the embryo, including in fetal liver, fetal lung, fetal kidney, fetal thymus (at protein level). Also expressed follicles of ovary, as well as in gonocytes of testis, spermatogonia, semen, oocytes and placenta (at protein level). Expressed in various cancers, including testis and lung cancers (at protein level), as well as kidney, prostate and trachea cancers.INDUCTION May be up-regulated in response to CTNNB1/beta-catenin activation.DOMAIN Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules. KH3 and KH4 mediate association with the cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only KH2 NES is XPO1-dependent. Both NES may be redundant, since individual in vitro mutations do not affect subcellular location of the full-length protein. The 4 KH domains are important to suppress HIV-1 infectivity.PTM Phosphorylated. Phosphorylation may impair association with ACTB mRNA and hence abolishes translational repression (By similarity).SIMILARITY Belongs to the RRM IMP/VICKZ family. uniprot. Q9NZI8.

链坐标

平等的

577.

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Reactome DB_ID: 428327

IGF2BP1：RNA [Cytosol]

IGF2BP1:核糖核酸

从Reactome中的EntitySet转换而来

反应DB_ID：428308

Reactome DB_ID: 428366

平等的

577.

平等的

Reactome数据库ID Release 77 428327 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428327 Reactome r - hsa - 428327

Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-428327.1 Reactome数据库ID Release 77 428296 数据库标识符。使用此URL将此实例的网页连接到反乐中：http：//www.reaconome.org/cgi-bin/eventbrowser?db=gk_current&id=428296 Reactome r - hsa - 428296

Reactome稳定的标识符。使用此URL将此实例的网页连接到反乐中：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-428296.2 16778892 Pubmed 2006 CRD-BP鉴于Beta-catenin信号传导介导BetatrCP1和C-Myc mRNA的稳定化 Noubissi，FK. Elcheva,我 Bhatia，N Shakoori, Ougolkov, 刘,我 Minamoto，T. 罗斯,我福克斯,SY Spiegelman，VS. 自然441:898 - 901 19029303. Pubmed 2009 igf2bp1相关细胞质rna对c-myc mRNA稳定性的控制 Weidensdorfer D Stohr N Baude，A 莱德尔,M Köhn，M. Schierhorn, Buchmeier,年代 Wahle,埃尔 Huttelmaier,年代 RNA 15:104-15 12894594 Pubmed 2003 CRD-BP：具有群体表达模式的C-Myc mRNA稳定蛋白 ioannidis，p 马赫拉，L. 帕帕多洛鲁，A 特谢拉,奥赫姆，S 安徒生,是 Evangelou E Dafni U Pandis，N Trangas，T. 抗癌res 23：2179-83 15601260 Pubmed 2005 VICKZ蛋白:一个多才能的调节rna结合蛋白家族 Yisraeli, JK BIOL CELL 97：87-96 16541107. Pubmed 2006 rna结合IMPs促进细胞粘附和侵袭性足的形成 Vikesaa，J. 汉森，电视杰克森，L. 博,R 组合名称,嗯克里斯琴森J 尼尔森，FC EMBO J 25：1456-68 9891060 Pubmed 1999 胰岛素样生长因子II mrna结合蛋白家族在发育后期抑制翻译尼尔森,J 克里斯琴森J Lykke-Andersen，J 约翰森,啊组合名称,嗯尼尔森，FC Mol Cell Biol 19:1262-70 11713986 Pubmed 2001 参与RNA贩运的IGF-II mRNA结合蛋白（IMP）的家族尼尔森，FC 尼尔森,J 克里斯琴森J Scand J Clin Lab Invest Spect 234：93-9 17652133 Pubmed 2007 VICKZ蛋白通过其RNA结合活性介导细胞迁移 Oberman F 兰特，K 该种Y 鲁宾斯坦，AM Yisraeli, JK RNA 13:1558 - 69 20371350 Pubmed 2010 利用PAR-CLIP对rna结合蛋白和microRNA靶点的转录组范围鉴定赫布纳，M. 陆地运动员，M 汉堡,我 Khorshid, M haus J Berninger，P Rothballer, ascano m，jr Jungkamp,交流 Munschauer，M 乌尔里希, 瓦尔德,GS Dewell，S Zavolan，M. Tuschl,托马斯细胞141:129-41 20080952 Pubmed 2010 ZBP1识别Beta-Actin Zipcode诱导RNA循环曹国伟,JA Patskovsky，Y. Patel，V. Levy, M Almo，SC. 歌手，罗伯特基因Dev 24:148-58 10875929. Pubmed 2000 H19 RNA结合胰岛素样生长因子II mrna结合蛋白的四个分子龙格,年代尼尔森，FC 尼尔森,J Lykke-Andersen，J 组合名称,嗯克里斯琴森J J Biol Chem 275:29562-9 12024010. Pubmed 2002 通过平移暂停的转化暂停决定簇通过平移暂停调节C-MYC mRNA衰减 Lemm,我罗斯,我 Mol Cell Biol 22:3959-69

IGF2BP2结合特定的rna

胰岛素样生长因子mRNA结合因子-2（IGF2BP2也称为IMP2和VICKZ2）结合含有序列基序CAUH的几种特异性RNA（其中H是H是A，C或U）。结合导致RNA的稳定性和亚细胞定位。<含有IGF2 mRNA的同种型含有引导件-3的IGF2BP2在5'UTR处的抑制翻译（IGF2的其他同种型是组成型）。
IGF2BP2可能是一个因果因子2型糖尿病。

发表于:《中国科学院院刊》2009-07-04 综述:Chao, JA, 2010-05-30 歌手，RH, 2010-05-30 编辑：5月，B，2009-07-04 从Reactome中的EntitySet转换而来

Reactome DB_ID: 428328

IGF2BP2结合的rna[胞质] 从Reactome中的EntitySet转换而来。每个同义词是一个PhysicalEntity的名称，每个XREF指向一个PhysicalEntity IGF2-001 mRNA [cytosol] IGF2-002 mRNA [cytosol]

反应DB_ID：428302

UNIPROT：Q9Y6M1 IGF2BP2

IGF2BP2.

IMP2. vickz2. IGF2BP2. 功能RNA结合因子促进靶转录物到细胞质蛋白-RNA复合物（MRNP）。该转录物“Caiving”进入MRNP允许MRNA运输和瞬态存储。它还调节目标转录物遇到翻译设备的速率和位置，并从内切核酸酶攻击或微小核糖介导的降解（通过相似性）。与胰岛素样生长因子2（IGF2）mRNA的5'-UTR结合。绑定是同种型的特异性。与β-肌动蛋白/ actB和MYC转录物结合。津株可以以RNA依赖性方式用IGF2BP1和IGF2BP3与IGF2BP1和IGF2BP3形成卤代聚物和芳寡糖。与HNRPD和IGF2BP1相互作用。用ELAVL1，DHX9和HNRNPU.Tissue特异性在卵母细胞中表达，小型和生长卵泡，LEYDIG细胞，精液和精液（蛋白质水平）的颗粒细胞表达。在睾丸癌（蛋白质水平）中表达。心脏，胎盘，骨骼肌，骨髓，结肠，肾，唾液腺，睾丸和胰腺表达弱。 Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.DOMAIN Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.MISCELLANEOUS Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.SIMILARITY Belongs to the RRM IMP/VICKZ family. uniprot. Q9Y6M1

平等的

599.

平等的

Reactome DB_ID: 428335

IGF2BP2：RNA [Cytosol]

IGF2BP2：RNA.

从Reactome中的EntitySet转换而来

Reactome DB_ID: 428328

反应DB_ID：428302

平等的

599.

平等的

Reactome数据库ID Release 77 428335 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428335 Reactome R-HSA-428335

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428335.1 Reactome数据库ID Release 77 428293 数据库标识符。使用此URL在反垃圾中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=428293 Reactome r - hsa - 428293

Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-428293.2 18618095 Pubmed 2008 CDKAL1和IGF2BP2的变体影响高血糖夹持期间的第一阶段胰岛素分泌 groenewoud，mj. 德克,JM Fritsche, reiling，E. Nijpels，G Heine，RJ. Maassen, JA Machicao F Schäfer，SA 哈林,汉斯 LM, t哈特 van haeften，tw Diabetologia 51:1659 - 63 19429674 Pubmed 2009 IGF2 mRNA结合蛋白2 - 2型糖尿病中的生物功能和调用作用克里斯琴森J Kolte，A 汉森，T. 尼尔森,F J Mol Endocrinol.

IGF2BP3结合特定的rna

胰岛素样生长因子mRNA结合因子-3（IGF2BP3也称为IMP3和VICKZ3）结合含有序列基序CAUH的几种特异性RNA（其中H是A，C或U）。结合导致RNA的稳定性和亚细胞定位。<含有IGF2 mRNA的同种型通过IGF2BP3在5'UTR处的结合，抑制翻译（IGF2的其他同种型是本构异构体）。

发表于:《中国科学院院刊》2009-07-04 综述:Chao, JA, 2010-05-30 歌手，RH, 2010-05-30 编辑：5月，B，2009-07-04 从Reactome中的EntitySet转换而来

Reactome DB_ID: 428384

RNA由IGF2BP3 [Cytosol]绑定从Reactome中的EntitySet转换而来。每个同义词是一个PhysicalEntity的名称，每个XREF指向一个PhysicalEntity IGF2-001 mRNA [cytosol] CD44 mRNA同种型202 [cytosol] CD44 mRNA同种型205 [cytosol] IGF2-002 mRNA [cytosol] CD44 mRNA同种型201 [Cytosol] CD44 mRNA同种型204 [cytosol] CD44 mRNA同种型203 [cytosol]

反应DB_ID：428313

UniProt: O00425 IGF2BP3

IGF2BP3.

KOC1 Vickz3. IMP3. IGF2BP3. 功能RNA结合因子可以募集到细胞质蛋白-RNA复合物（MRNP）的靶量转录物。该转录物“Caiving”进入MRNP允许MRNA运输和瞬态存储。它还调节目标转录物遇到翻译设备的速率和位置，并从内切核酸酶攻击或微小核糖介导的降解中屏蔽它们。结合CD44 mRNA的3'-UTR并稳定，因此促进细胞粘附和invidopodia在癌细胞中形成。与β-肌动蛋白/ actb和myc转录物结合。结合胰岛素样生长因子2（IGF2）mRNAs.SubUnit的5'-UTR可以以RNA依赖性方式与IGF2BP1和IGF2BP3形成碘聚物和氧脱球剂。与IGF2BP1互动。与ELAVL1，DHX9和HNRNPU.Tissue特异性在胎儿肝脏，胎儿肺，胎儿肾，胎儿胸腺，胎儿胎盘，卵巢和腺细胞腺细胞和睾丸，生长卵母细胞，精液和精液（蛋白质水平）中表达的特异性。在子宫颈腺癌中表达，睾丸，胰腺和肾 - 细胞癌（在蛋白质水平）中。在妊娠的8和14周的胎儿发育中普遍表达。 Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.DOMAIN All KH domains contribute binding to target mRNA. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.MISCELLANEOUS Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas.SIMILARITY Belongs to the RRM IMP/VICKZ family. uniprot. O00425

平等的

579.

平等的

反应DB_ID：428310

IGF2BP3：RNA [Cytosol]

IGF2BP3：RNA.

从Reactome中的EntitySet转换而来

Reactome DB_ID: 428384

反应DB_ID：428313

平等的

579.

平等的

Reactome数据库ID Release 77 428310 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428310 Reactome R-HSA-428310

Reactome稳定的标识符。使用此URL将此实例的网页连接到反乐中：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-428310.1 Reactome数据库ID Release 77 428287 数据库标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=428287 Reactome R-HSA-428287

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428287.2

Reactome数据库ID Release 77 428359. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=428359 Reactome R-HSA-428359

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-428359.3 去 0043488

去生物过程