从“SPP1（Osteopontin）转换的BIoPAX途径在反应数据库中绑定整合蛋白alpha8beta1”。 SPP1（Osteopontin）绑定整合素Alpha8beta1

SPP1（Osteopontin）绑定整合素Alpha8beta1

Osteopontin（SPP1）是一种高磷酸化的唾液酸蛋白，是骨骼和牙齿的矿化细胞外基质的突出组分。它绑定多个整合素，包括AlphaVbeta3，AlphaVbeta1和Alphavbeta5（Liaw等人1995）Alpha9beta1（Smith等，1996，Yokosaki等，1999），Alpha4beta1（Bayliss等，1998），Alpha8Beta1（Denda等，1998）和受体CD44（katagiri等1999）。

撰写：Geiger，B，Horwitz，R，2008-05-07 08:30:32 审查：山田，k，汉普里斯，MJ，海恩斯，r，2008-05-07 08:53:37 审查：Ricard-Blum，Sylvie，2013-08-13 编辑:Garapati, P V, 2008-03-11 10:20:45

反应DB_ID：215967

细胞外区域走 0005576.

UNIPROT：P10451 SPP1

SPP1.

BNSP. SPP1. PSEC0156. opn. 功能主要的非胶原骨蛋白，紧密结合到羟基磷灰石。似乎形成了矿化矩阵的一个组成部分。对细胞基质相互作用的可能性可能是一种涉及增强干扰素-γ-12的产生的细胞因子并减少白细胞介素-10的产生，并且在导致I型免疫的途径中是必不可少的。联合素α-V / beta-3.令人骨质特异性骨骼。在plasma.PTM发现形成由转谷氨酰胺酶介导的TGM2共价交联，谷氨酰胺和ε-氨基的赖氨酸残基之间，形成均聚物和杂聚物，增加其胶原结合properties.PTM广泛地在细胞外介质中磷酸化通过在FAM20Cmultiple sites within the S-x-E/pS motif.PTM O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62.SIMILARITY Belongs to the osteopontin family. 反应 http://www.reacectome.org. HOMO SAPIENS.

NCBI分类学 9606 uniprot. P10451.

链坐标

17.

平等的

314.

平等的

反应DB_ID：216012

血浆膜走 0005886. 整合素alpha8beta1 [血浆膜]

整合inalla8beta1.

反应DB_ID：57596

UNIPROT：P05556 ITGB1

ITGB1

ITGB1 MSK12 MDF2 FNRB. FUNCTION整α-1 /β-1，α-2 /β-1，α--10 /β-1和α-11 /β-1是受体胶原。整α-1 /β-1和α-2 /β-2识别脯氨酸的羟基化的序列g-F-P-G-E-R中的胶原蛋白。整α-2 /β-1，α-3 /β-1，α-4- /β-1，α-5 /β-1，α-8 /β-1，α--10 /β-1，α--11 /β-1和α-V /β-1是受体纤连蛋白。α-4 /β-1识别纤连蛋白的选择性剪接的CS-1和CS-5区域内的一个或多个结构域。整合素-5 /β-1为纤维蛋白原的受体。整α-1 /β-1，α-2 /β-1，α-6 /β-1和α-7 /β-1是受体lamimin。整合素-6 /β-1（ITGA6：ITGB1）存在于卵母细胞，并参与精子 - 卵子融合（通过相似性）。整合素-4 /β-1是用于VCAM1的受体。它可以识别序列Q-I-d-S在VCAM-1。整的α-9 /β-1是用于VCAM1，cytotactin和骨桥蛋白的受体。 It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).FUNCTION (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.FUNCTION (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5.FUNCTION (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4.FUNCTION (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19.FUNCTION (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus.FUNCTION (Microbial infection) Acts as a receptor for Mammalian reovirus.FUNCTION (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.SUBUNIT Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with FLNA, FLNB and RANBP9. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (By similarity). ITGA5:ITGB1 interacts with CCN3. ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415). ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 interacts with IL1B (PubMed:29030430). ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outgrowth (PubMed:15466886). ITGA5:ITGB1 interacts with ACE2 (PubMed:33102950).SUBUNIT (Microbial infection) Integrin ITGA2:ITGB1 interacts with human echoviruses 1 and 8 capsid proteins.SUBUNIT (Microbial infection) Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB.SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus/HHV-4 gB protein.SUBUNIT (Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid protein.SUBUNIT (Microbial infection) Integrin ITGA2:ITGB1 interacts with human rotavirus VP4 protein.SUBUNIT (Microbial infection) Interacts with mammalian reovirus capsid proteins.SUBUNIT (Microbial infection) Integrin ITGA5:ITGB1 interacts with HIV-1 Tat.SUBUNIT (Microbial infection) ITGA5:ITGB1 interacts with SARS coronavirus-2/SARS-CoV-2 spike protein.PTM The cysteine residues are involved in intrachain disulfide bonds.SIMILARITY Belongs to the integrin beta chain family. uniprot. P05556.

21.

平等的

798.

平等的

反应DB_ID：215943

UNIPROT：P53708 ITGA8

ITGA8.

ITGA8. 整合素alpha-8/beta-1通过调节间充质细胞向上皮结构的募集，在肾脏和可能的其他器官的发生中发挥作用。它能识别多种配体中的R-G-D序列，包括TNC, FN1, SPP1, TGFB1, TGFB3和VTN。NPNT可能是其在肾脏发生中的功能配体。TNC的神经元受体，它介导细胞间的相互作用并调节感觉神经元和运动神经元的突起生长。亚基亚基和亚基的异源二聚体。亚基由一个重链和一个轻链组成，由二硫键连接。Alpha-8和beta-1相关联。组织特异性表达于间充质细胞，包括肺泡肌成纤维细胞、肾系膜细胞、肝星状细胞、血管和内脏平滑肌(蛋白水平)。相似性属于整合素链家族。 uniprot. P53708.

39.

平等的

1063.

平等的

反应数据库ID版本77 216012 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser?db=gk_current&id=216012 反应 R-HSA-216012

反应稳定标识符。使用此URL在反垃圾邮件中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-216012.1

反应DB_ID：216006

整合素alpha8beta1:SPP1[质膜]

Integrin Alpha8beta1：SPP1

反应DB_ID：215967

17.

平等的

314.

平等的

反应DB_ID：216012

反应数据库ID版本77 216006 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=216006 反应 R-HSA-216006

反应稳定标识符。使用此URL在反垃圾中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-216006.1 反应数据库ID版本77 216061 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser?db=gk_current&id=216061 反应 R-HSA-216061

反应稳定标识符。使用此URL连接到该实例的网页中Reactome：//www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-216061.1 10593924 PubMed. 1999年整联蛋白α（9）β（1）与截骨型蛋白的凝血酶切割的氨基 - 末端片段中的新型识别序列（SVVYGLR）结合 Yokosaki，Y. Matsuura，N Sasaki，T. Murakami，I. 施耐德，H. Higashiyama，S Saitoh，Y. Yamakido, M 陶崎，Y. Sheppard，D J Biol Chem 274：36328-34 9892210 PubMed. 1999年 CD44变体但没有CD44s与含Beta1的整合素合作，以允许细胞独立于精氨酸 - 甘氨酸 - 天冬氨酸与骨桥蛋白结合，从而刺激细胞运动性和趋化性 katagiri，你 Slemememe，J. 富士，H. Herrlich，P Hotta，H. 田纳卡，K Chikuma，S. Yagita，H. okumura，k Murakami，M. Saiki，I. 房间，一个f 您,T 实用癌症杂志59:219-26 9614184 PubMed. 1998年骨桥蛋白的鉴定作为一种新型的配体对整联alpha8β1的作用和潜在作用于肾形态发生此整合素配体相互作用 Denda,年代 Reichardt，LF. 穆勒，U. Mol Biol Cell 9：1425-35 8910476. PubMed. 1996年骨桥蛋白N-末端结构域含有α9beta1整合素识别的隐秘粘合剂序列史密斯，LL. 张，香港凌，乐陈，J. Sheppard，D Pytela，R. Giacchelli，CM J Biol Chem 271：28485-91 9547293. PubMed. 1998年 Osteopontin是α4beta1整合素的配体贝瑞斯，kj. Meininger，Ga Scholtz，John M 戴维斯，GE J Cell SCI 111：1165-74 7532190. PubMed. 1995年骨桥蛋白的粘合剂和迁移效果通过不同的细胞表面整年蛋白介导。αVβ3在平滑肌细胞迁移到骨桥蛋白的作用 Liaw，L. Skinner，M P. 雨，e w 罗斯，R. Cheresh，D a Schwartz，S M Giacchelli，C M J. Clin。投资。95：713-24 21232243 PubMed. 0. 截骨疏松症潜在作用在心血管疾病中的分子与细胞生物学 Giacchelli，C M Schwartz，S M Liaw，L. 趋势Cardiovasc。Med。5：88-95