使用JSBML版本1.5在7/15/21下午1:28从Reactome版本77生成SBML。
TP53是最常见的突变肿瘤抑制基因，在超过50%的人类肿瘤中存在突变，TP53的种系突变是易感癌症Li-Fraumeni综合征的潜在原因(Monti et al. 2020)。TP53基因定位于染色体17p13带，并编码一个包含四个功能域的转录因子。反式激活域(TAD)涉及氨基酸残基1-61，并参与转录机制组成部分的相互作用。DNA结合域(DBD)包括94-290氨基酸残基，并与称为p53反应元件的特定DNA靶序列相互作用。c端结构域(CTD)涉及357-393残基并调节DNA结合(Monti et al. 2020)。四聚结构域(TD)涉及氨基酸325-355，是TP53同源四聚体形成所必需的。TP53被认为是“基因组的守护者”(Lane 1992)，因为它被DNA损伤激活启动，取决于损伤的程度、细胞周期阻滞、衰老或凋亡(Reinhardt和Schumacher 2012综述)。此外，TP53调节DNA修复基因的表达，并参与新陈代谢和自噬的调控(Monti et al. 2020)。大多数癌症衍生的TP53突变是影响TP53中心DNA结合域(氨基酸残基94-312)的错义突变。在近30%的tp53突变癌症中发现该区域的8个热点氨基酸取代(R175H、G245S、R248Q、R248W、R249S、R273H、R273S和R282W)。根据TP53突变对功能的影响，可以将其分为1)功能缺失(LOF)， 2)部分LOF(可能涉及温度敏感性); 3) wild type-like (WT-L) or super-transactivating (ST) mutants; 4) mutants with altered specificity (AS), which are active or partially active on some but inactive on other TP53 target genes; 5) dominant-negative (DN) mutants, able to tetramerize with and inhibit the activity of the wild type TP53 protein. Some of the TP53 mutants, especially in the category of ST and AS mutants, are gain-of-function (GOF) mutants, able to interact with novel target genes and/or novel components of the transcriptional machinery (reviewed in Monti et al. 2020, and Gencel-Augusto and Lozano 2020).Due to the complex function of WT-L, ST, AS and DN mutants of TP53, we have so far focused on annotating LOF mutants of TP53 which are unable to oligomerize due to mutations in the TD. Although accounting for a small percent of TP53 mutants, TD mutant are therefore considered to be completely defective in transcriptional activity, with no possibility of AS, DN and GOF effects (Chène and Bechter 1999, reviewed in Chène 2001, and Kamada et al. 2016). However, when overexpressed, some missense TD mutants of TP53 can form homotetramers and heterotetramers with the wild type TP53 which are partially functional and some extent of AS, DN and GOF effects may not be excluded for those mutants (Atz et al. 2000, reviewed in Chène 2001). In addition, the synthetic mutant p153(1-320) which consists of the first 320 amino acids and lacks the TD and CTD, while unable to tetramerize, can form stacked oligomers at the recombinant target gene promoter and induce transcription at a low level. Stacked oligomers are formed through interactions that involve amino acid residues outside the TD, which are facilitated by the presence of a target DNA sequence (Stenger et al. 1994).
从Reactome候选集派生。一个实体列表，其中一个或多个实体可以执行给定的功能
一些无义及移截短的导致在缺乏四聚结构域（TD）突变TP53蛋白。此外，几个错义突变影响四聚结构域，其，一些像L344P，已被证明阻碍四聚（CHENE和1999 Bechter;鲁宾等人2010）。下面TD错义突变已经显示出妨碍的能力TP53到tetramerize：TP53 L330H（Rollenhagen和1998 CHENE：部分活性过表达时;物Atz等人，2000; Kamada等人，2011：。的功能部分丧失）TP53 L330P（Kamada等人，2011。）TP53 L330R（Kamada等人。2011）TP53 G334V（ATZ等人，2000; Kamada等人，2011：部分TP53 R337C（Davison等人，1998，洛马克斯等1998失功能），Kamada等人2011：。的功能部分丧失;Rollenhagen和1998 CHENE：部分活性过表达时;物Atz等2000）TP53 R337H（高德等人2008; DiGiammarino等人，2002：所述四聚结构域的pH依赖性不稳定; Kamada等人，2011：。能够tetramerize，但四聚物是在生理温度下是不稳定的）TP53 R337L（Rollenhagen和CHENE 1998：部分LY活性过量表达时;镰田等人。2011：能够tetramerize，但四聚物是在生理温度下）TP53 R337P（Kamada等人，2011）TP53 F338I（Kamada等人，2011不稳定：。的功能部分丧失）TP53 F341C（Kamada等人，2011：功能部分丧失）TP53 R342P（Rollenhagen和1998 CHENE; CHENE和1999 Bechter，Kamada等人2011）TP53 L344P（石冈等人1997; 1999 CHENE和Bechter; Davison等人1998;洛马克斯等人1998; Rollenhagen和1998 CHENE;鲁宾等人2010; Kamada等人，2011）TP53 L344R（Kamada等人，2011：。。的功能部分丧失）TP53 A347T（Kamada等人，2011：TP53 L348S（镰2011等的功能）部分损失：的功能部分丧失）TP53 K351E（石冈等人，1997）下面的TP53 TD错义突变体，其四聚能力仍未得到研究注释为候选者，因为它们类似于功能特征TP53 TD错义突变体四聚的损失：TP53 L330F（类似于TP53 L330H）TP53 L330I（类似于TP53 L330H）TP53 G334E（类似于TP53ģ334V)TP53 R337G (similar to TP53 R337C and TP53 R337L)TP53 R337S (similar to TP53 R337C and TP53 R337L)TP53 F341L (similar to TP53 F341C)TP53 F341S (similar to TP53 F341C)TP53 F341V (similar to TP53 F341C)TP53 A347D (similar to TP53 A347T)TP53 A347P (similar to TP53 A347T)TP53 K351N (similar to TP53 K351E)TP53 K351R (similar to TP53 K351E)The TD missense mutant TP53 R342Q, which is similar to TP53 R342P, as well as the missense mutants TP53 E349D and TP53 Q354R, were not annotated because they were shown to be able to oligomerize with a recombinant wild type TP53 protein and activate transcription from the CDKN1A (p21) target promoter (Rollenhagen and Chène 1998) and to form homotetramers in vitro at a level similar to the wild type protein (Kamada et al. 2011). In addition, the following TD missense mutants of TP53 were found to tetramerize in vitro at a level not significantly different the wild type TP53, although the stability of some of the tetramers is reduced compared to the wild type tetramers; these mutants have not been annotated even if they share the sequence similarity with functionally impacted missense mutants:TP53 E326G (Kamada et al. 2011)TP53 Y327D (Kamada et al. 2011)TP53 Y327H (Kamada et al. 2011)TP53 Y327S (Kamada et al. 2011)TP53 F328L (Kamada et al. 2011)TP53 F328S (Kamada et al. 2011)TP53 F328V (Kamada et al. 2011)TP53 T329I (Kamada et al. 2011)TP53 T329S (Kamada et al. 2011)TP53 Q331H (Kamada et al. 2011)TP53 Q331P (Kamada et al. 2011)TP53 Q331R (Kamada et al. 2011)TP53 I332V (Kamada et al. 2011)TP53 G334W (Kamada et al. 2011)TP53 R335G (Kamada et al. 2011)TP53 R335H (Kamada et al. 2011)TP53 R335L (Kamada et al. 2011)TP53 F338L (Kamada et al. 2011)TP53 E339K (Kamada et al. 2011)TP53 E339Q (Kamada et al. 2011)TP53 R342L (Kamada et al. 2011)TP53 R342Q (Kamada et al. 2011)TP53 E343G (Kamada et al. 2011)TP53 E346A (Kamada et al. 2011)TP53 A347G (Kamada et al. 2011)TP53 L348F (Kamada et al. 2011)TP53 D352H (Kamada et al. 2011)TP53 A353T (Kamada et al. 2011)TP53 Q354E (Kamada et al. 2011)TP53 Q354K (Kamada et al. 2011)Two nonsense mutants of TP53, TP53 K351* and TP53 Q354*, in which truncation occurs at the very end of the TD, were shown to retain, at least partially, the ability to form dimers and, in the case of TP53 Q354* tetramers, as well as to be able to inhibit colony formation to some extent (Ishioka et al. 1997). These two mutants have been annotated as candidates. Other TP53 truncation mutants annotated as candidates for the loss of tetramerization ability are nonsense and frameshift cancer mutants in which the stop codon occurs upstream of the TD or affects the first three amino acids of the TD. These mutants have not been functionally studied but resemble the synthetic mutant p153 (1-320) which consists of the first 320 amino acids and lacks the TD and the C-terminal domain (CTD). This mutant is unable to tetramerize, but can form stacked oligomers at the recombinant target gene promoter and induce transcription at a low level. Stacked oligomers are formed through interactions that involve amino acid residues outside the TD, which are facilitated by the presence of the target DNA sequence (Stenger et al. 1994). In some of the candidate truncation mutants the stop codon occurs close to the N-terminus, and these mutants are likely to represent null mutants.The following nonsense mutants of TP53 reported in cancer have been annotated as candidates:TP53 Q5*TP53 E11*TP53 Q16*TP53 S20*TP53 W23*TP53 S33*TP53 L35*TP53 Q38*TP53 L43*TP53 D48*TP53 I50*TP53 E51*TP53 Q52*TP53 W53*TP53 E56*TP53 D61*TP53 E62*TP53 R65*TP53 E68*TP53 W91*TP53 S94*TP53 Q100*TP53 K101*TP53 Y103*TP53 Q104*TP53 Y107*TP53 L114*TP53 K120*TP53 C124*TP53 Y126*TP53 K132*TP53 C135*TP53 Q136*TP53 K139*TP53 C141*TP53 Q144*TP53 W146*TP53 D148*TP53 Y163*TP53 K164*TP53 Q165*TP53 S166*TP53 Q167*TP53 E171*TP53 V173*TP53 R174*TP53 C176*TP53 H179*TP53 E180*TP53 C182*TP53 S183*TP53 D186*TP53 L188*TP53 Q192*TP53 R196*TP53 E198*TP53 G199*TP53 L201*TP53 E204*TP53 Y205*TP53 L206*TP53 D208*TP53 R209*TP53 R213*TP53 Y220*TP53 E221*TP53 P223*TP53 E224*TP53 S227*TP53 D228*TP53 C229*TP53 Y234*TP53 Y236*TP53 M237*TP53 C238*TP53 N239*TP53 S240*TP53 C242*TP53 M243*TP53 M246*TP53 R248*TP53 E258*TP53 S261*TP53 G266*TP53 N268*TP53 E271*TP53 C275*TP53 C277*TP53 G279*TP53 R280*TP53 E285*TP53 E286*TP53 E287*TP53 K291*TP53 K292*TP53 G293*TP53 E294*TP53 E298*TP53 K305*TP53 R306*TP53 S315*TP53 Q317*TP53 K319*TP53 K320*TP53 K321*TP53 G325*TP53 Y327*The following frameshift mutants of TP53 reported in cancer have been annotated as candidates: TP53 L14Sfs*15TP53 F19Ifs*10TP53 N29Kfs*14TP53 N30Kfs*13TP53 S33Ffs*10TP53 L35Ffs*8TP53 L35Pfs*10TP53 P36Afs*7TP53 M40Ifs*3TP53 M40Lfs*7TP53 D41Gfs*2TP53 D42Qfs*5TP53 L43Cfs*9TP53 S46Vfs*6TP53 D48Gfs*4TP53 D49Efs*3TP53 E51Gfs*6TP53 Q52Pfs*5TP53 Q52Lfs*73TP53 W53Cfs*4TP53 W53Mfs*4TP53 E56Vfs*73TP53 D57Kfs*67TP53 D57Tfs*72TP53 P58Rfs*6TP53 P60Vfs*64TP53 E62Kfs*65TP53 A63Tfs*66TP53 R65Tfs*84TP53 R65Kfs*84TP53 R65Qfs*84TP53 M66Tfs*60TP53 M66Nfs*83TP53 E68Rfs*81TP53 A69Gfs*80TP53 P71Sfs*78TP53 V73Afs*76TP53 V73Rfs*51TP53 V73Rfs*76TP53 V73Afs*51TP53 A74Gfs*50TP53 A74Gfs*75TP53 P75Lfs*74TP53 P77Cfs*73TP53 A78Sfs*71TP53 A78Gfs*73TP53 T81Nfs*68TP53 T81Sfs*43TP53 P82Afs*70TP53 P82Hfs*42TP53 A83Gfs*66TP53 A84Vfs*65TP53 A84Gfs*65TP53 A86Gfs*63TP53 A86Cfs*63TP53 A88Sfs*61TP53 S90Lfs*59TP53 S90Pfs*34TP53 P92Hfs*57TP53 P92Afs*57TP53 L93Pfs*59TP53 L93Afs*57TP53 S94Ffs*55TP53 S94Cfs*30TP53 S95Ifs*54TP53 S95Hfs*29TP53 S96Yfs*53TP53 S96Ffs*53TP53 V97Tfs*66TP53 P98Yfs*26TP53 S99Ffs*55TP53 Q100Sfs*54TP53 T102Nfs*47TP53 Y103Lfs*46TP53 Y103Efs*23TP53 Q104Pfs*45TP53 S106Qfs*43TP53 S106Gfs*44TP53 G108Rfs*41TP53 F109Tfs*16TP53 R110Qfs*15TP53 R110Pfs*39TP53 R110Pfs*14TP53 R110Sfs*14TP53 L111Qfs*13TP53 L111Ffs*40TP53 L111Nfs*14TP53 F113Lfs*11TP53 F113Pfs*37TP53 L114Ffs*35TP53 H115Afs*34TP53 S116Afs*34TP53 G117Wfs*32TP53 T118Nfs*31TP53 T118Dfs*31TP53 T118Gfs*6TP53 A119Qfs*5TP53 A119Rfs*6TP53 K120Tfs*2TP53 K120Qfs*29TP53 S121Ifs*28TP53 V122Cfs*27TP53 T123Dfs*26TP53 T123Rfs*48TP53 C124Wfs*25TP53 C124Lfs*25TP53 C124Ffs*47TP53 T125Hfs*24TP53 T125Afs*46TP53 T125Ifs*47TP53 T125Lfs*25TP53 P128Tfs*21TP53 A129Vfs*20TP53 A129Pfs*42TP53 A129Cfs*20TP53 L130Pfs*41TP53 L130Pfs*19TP53 L130Cfs*20TP53 N131Pfs*19TP53 M133Rfs*38TP53 M133Dfs*16TP53 M133Lfs*42TP53 C135Ffs*36TP53 C135Lfs*14TP53 Q136Sfs*13TP53 Q136Pfs*13TP53 A138Gfs*11TP53 T140Dfs*9TP53 C141Wfs*8TP53 P142Afs*7TP53 V143Rfs*6TP53 V143Lfs*28TP53 V143Afs*29TP53 Q144Pfs*5TP53 Q144Afs*5TP53 L145Afs*4TP53 W146Vfs*3TP53 D148Efs*23TP53 D148Gfs*2TP53 S149Ffs*32TP53 P151Tfs*30TP53 P152Hfs*29TP53 P152Lfs*29TP53 P152Tfs*30TP53 P153Lfs*28TP53 P153Sfs*28TP53 P153Afs*28TP53 G154Afs*18TP53 G154Pfs*28TP53 G154Rfs*27TP53 G154Afs*28TP53 T155Hfs*26TP53 T155Afs*28TP53 R156Lfs*25TP53 R156Pfs*25TP53 R156Hfs*26TP53 V157Afs*24TP53 V157Rfs*24TP53 R158Sfs*23TP53 A161Gfs*20TP53 I162Wfs*10TP53 Y163Lfs*18TP53 Q165Hfs*17TP53 S166Ifs*15TP53 Q167Nfs*4TP53 Q167Tfs*14TP53 Q167Hfs*4TP53 M169Ifs*12TP53 E171Gfs*4TP53 R175Afs*6TP53 H178Qfs*3TP53 H178Pfs*3TP53 H178Pfs*70TP53 H179Pfs*2TP53 C182Afs*66TP53 S183Tfs*65TP53 D184Rfs*2TP53 D184Efs*64TP53 L188Tfs*21TP53 A189Cfs*20TP53 A189Gfs*20TP53 P191Sfs*18TP53 Q192Pfs*17TP53 I195Nfs*14TP53 I195Yfs*14TP53 I195Lfs*53TP53 R196Pfs*13TP53 E198Gfs*11TP53 G199Rfs*10TP53 N200Kfs*9TP53 L201Ffs*8TP53 L201Ifs*47TP53 R202Afs*7TP53 R202Kfs*9TP53 E204Wfs*44TP53 E204Gfs*46TP53 Y205Sfs*4TP53 Y205Lfs*4TP53 Y205Ffs*8TP53 L206Ffs*42TP53 L206Yfs*4TP53 L206Ffs*3TP53 D207Lfs*41TP53 D207Gfs*2TP53 D207Ffs*3TP53 D208Ffs*42TP53 N210Kfs*6TP53 N210Tfs*7TP53 R213Sfs*3TP53 R213Ffs*35TP53 H214Qfs*2TP53 H214Tfs*2TP53 S215Kfs*7TP53 S215Ifs*33TP53 S215Ifs*36TP53 V217Gfs*31TP53 V218Gfs*4TP53 V218Gfs*30TP53 V218Wfs*30TP53 P219Afs*3TP53 Y220Lfs*2TP53 Y220Hfs*5TP53 E221Vfs*4TP53 P222Sfs*26TP53 P223Sfs*26TP53 P223Rfs*4TP53 E224Afs*2TP53 S227Vfs*2TP53 S227Wfs*3TP53 T230Sfs*11TP53 T231Nfs*9TP53 T231Ffs*15TP53 H233Vfs*8TP53 Y234Ifs*6TP53 Y234Sfs*15TP53 Y234Pfs*7TP53 N239Kfs*25TP53 S240Kfs*24TP53 S240Qfs*24TP53 C242Lfs*22TP53 G244Afs*4TP53 G244Tfs*19TP53 G245Vfs*19TP53 M246Afs*19TP53 M246Rfs*19TP53 R248Pfs*16TP53 R249Kfs*15TP53 L252Pfs*12TP53 T253Nfs*11TP53 T253Ifs*93TP53 T253Hfs*11TP53 I255Nfs*9TP53 T256Nfs*8TP53 T256Ifs*90TP53 T256Hfs*8TP53 L257Hfs*89TP53 L257Hfs*9TP53 E258Gfs*6TP53 D259Rfs*5TP53 S260Lfs*4TP53 S261Tfs*2TP53 L264Sfs*8TP53 L265Tfs*7TP53 R267Tfs*5TP53 N268Kfs*4TP53 N268Efs*4TP53 S269Kfs*3TP53 F270Lfs*2TP53 R273Lfs*33TP53 R273Cfs*73TP53 V274Cfs*32TP53 V274Afs*33TP53 C275Lfs*31TP53 A276Lfs*31TP53 P278Lfs*28TP53 P278Lfs*68TP53 P278Sfs*28TP53 G279Sfs*68TP53 G279Pfs*69TP53 R280Sfs*66TP53 R280Efs*26TP53 D281Afs*26TP53 D281Efs*26TP53 R282Pfs*64TP53 R282Pfs*24TP53 R283Lfs*23TP53 R283Sfs*23TP53 R283Pfs*24TP53 T284Hfs*22TP53 E285Rfs*21TP53 E286Hfs*22TP53 N288Ifs*18TP53 N288Kfs*18TP53 N288Kfs*59TP53 R290Sfs*56TP53 K291Qfs*15TP53 K292Lfs*54TP53 G293Rfs*13TP53 E294Vfs*12TP53 E294Gfs*12TP53 P295Rfs*12TP53 H297Lfs*9TP53 H297Sfs*10TP53 E298Tfs*48TP53 L299Afs*7TP53 G302Vfs*44TP53 G302Rfs*4TP53 S303Efs*3TP53 T304Lfs*3TP53 T304Yfs*2TP53 T304Qfs*44TP53 R306Lfs*32TP53 R306Afs*31TP53 A307Gfs*30TP53 A307Rfs*39TP53 A307Sfs*30TP53 A307Lfs*32TP53 L308Sfs*30TP53 L308Afs*6TP53 P309Lfs*31TP53 N310Kfs*27TP53 N310Qfs*27TP53 N311Kfs*26TP53 N311Qfs*26TP53 T312Nfs*25TP53 S313Lfs*45TP53 S313Pfs*33TP53 S315Pfs*31TP53 P316Lfs*21TP53 P316Sfs*21TP53 P316Lfs*30TP53 Q317Pfs*20TP53 K319Nfs*18TP53 K319Afs*19TP53 K320Efs*17TP53 K321Efs*16TP53 P322Tfs*15TP53 D324Rfs*13TP53 D324Afs*29TP53 P13Lfs*2TP53 S15Rfs*28TP53 Q16Rfs*28TP53 T18Hfs*26TP53 S20Qfs*24TP53 D21Tfs*23TP53 L22Yfs*22TP53 K24Nfs*20TP53 L26Pfs*11TP53 L26Qfs*13TP53 P27Lfs*17TP53 N29Kfs*13TP53 N29Tfs*15TP53 N30Tfs*14TP53 L32Pfs*11TP53 L32Cfs*12TP53 S33Vfs*6TP53 S33Pfs*11TP53 P34Lfs*8TP53 L35Ffs*7TP53 L35Cfs*9TP53 P36Tfs*75TP53 P36Wfs*4TP53 P36Rfs*8TP53 S37Cfs*79TP53 Q38Wfs*4TP53 Q38Sfs*4TP53 Q38Kfs*6TP53 A39Mfs*3TP53 A39Qfs*5TP53 D41Mfs*3TP53 L43Afs*7TP53 M44Tfs*75TP53 M44Sfs*79TP53 M44Afs*7TP53 M44Cfs*79TP53 L45Pfs*5TP53 L45Vfs*6TP53 S46Pfs*77TP53 P47Hfs*2TP53 P47Gfs*4TP53 P47Rfs*76TP53 D48Efs*75TP53 D48Tfs*75TP53 D49Yfs*2TP53 I50Mfs*4TP53 I50Nfs*72TP53 I50Mfs*73TP53 E51Pfs*59TP53 E51Dfs*72TP53 E51Nfs*72TP53 Q52Kfs*67TP53 Q52Lfs*68TP53 Q52Hfs*71TP53 Q52Nfs*71TP53 W53Yfs*2TP53 W53Gfs*70TP53 F54Lfs*69TP53 F54Sfs*69TP53 T55Pfs*52TP53 T55Mfs*68TP53 E56Kfs*67TP53 E56Rfs*6TP53 D57Sfs*86TP53 D57Vfs*64TP53 P58Qfs*65TP53 G59Qfs*84TP53 G59Efs*58TP53 G59Vfs*64TP53 P60Qfs*63TP53 D61Vfs*62TP53 A63Lfs*60TP53 R65Cfs*79TP53 R65Efs*58TP53 M66Ifs*76TP53 M66Qfs*56TP53 M66Gfs*80TP53 M66Sfs*57TP53 P67Lfs*54TP53 P67Rfs*81TP53 P67Qfs*56TP53 E68Rfs*55TP53 E68Gfs*80TP53 A69Vfs*54TP53 A69Cfs*79TP53 A69Lfs*54TP53 A70Rfs*76TP53 P71Wfs*50TP53 P71Gfs*75TP53 P72Lfs*48TP53 P72Rfs*76TP53 V73Lfs*43TP53 V73Gfs*50TP53 V73Wfs*50TP53 A74Qfs*45TP53 A74Sfs*71TP53 A74Pfs*49TP53 P75Yfs*68TP53 P75Lfs*48TP53 A76Vfs*55TP53 A76Hfs*47TP53 P77Lfs*44TP53 P77Rfs*71TP53 P77Sfs*71TP53 P77Qfs*46TP53 A78Yfs*68TP53 A78Qfs*45TP53 P80Rfs*41TP53 P80Lfs*43TP53 T81Pfs*49TP53 T81Nfs*42TP53 P82Rfs*41TP53 P82Gfs*66TP53 A83Cfs*30TP53 A83Pfs*35TP53 A83Cfs*63TP53 A83Pfs*39TP53 A83Gfs*65TP53 A83Rfs*40TP53 A84Pfs*35TP53 A84Pfs*39TP53 P85Lfs*58TP53 P85Lfs*59TP53 P85Hfs*37TP53 P85Cfs*63TP53 P85Lfs*38TP53 A86Vfs*55TP53 A86Gfs*32TP53 A86Pfs*33TP53 A86Pfs*34TP53 A86Lfs*59TP53 P87Ifs*54TP53 P87Lfs*59TP53 P87Qfs*36TP53 A88Gfs*44TP53 A88Vfs*55TP53 A88Gfs*32TP53 A88Pfs*35TP53 S90Pfs*33TP53 W91Vfs*13TP53 W91Cfs*52TP53 W91Cfs*57TP53 W91Cfs*32TP53 W91Gfs*32TP53 P92Vfs*55TP53 L93Ffs*53TP53 L93Rfs*30TP53 L93Vfs*55TP53 L93Cfs*30TP53 S94Pfs*24TP53 S94Ffs*28TP53 S94Yfs*29TP53 S94Hfs*29TP53 S94Ifs*54TP53 S95Gfs*37TP53 S95Ffs*53TP53 S95Lfs*28TP53 S96Lfs*27TP53 S96Cfs*52TP53 V97Sfs*26TP53 V97Lfs*25TP53 P98Lfs*25TP53 S99Rfs*23TP53 S99Pfs*24TP53 Q100Gfs*37TP53 Q100Lfs*42TP53 Q100Rfs*23TP53 K101Lfs*42TP53 T102Pfs*45TP53 T102Pfs*21TP53 Y103Vfs*15TP53 Y103Lfs*42TP53 Y103Gfs*44TP53 Y103Rfs*19TP53 Y103Tfs*20TP53 Q104Afs*18TP53 Q104Rfs*19TP53 G105Afs*18TP53 S106Vfs*15TP53 S106Rfs*16TP53 S106Tfs*17TP53 Y107Tfs*44TP53 Y107Sfs*38TP53 Y107Vfs*13TP53 Y107Tfs*16TP53 G108Afs*34TP53 G108Afs*39TP53 G108Vfs*13TP53 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